Structure-activity relationship of an ozonide carboxylic acid (OZ78) against <em>Fasciola hepatica</em> (Publications)
In this paper, we describe the SAR of ozonide carboxylic acid OZ78 (1) as the first part of our search for a trematocidal synthetic peroxide drug development candidate. We found that relatively small
Mobile phone use and the risk of skin cancer: a nationwide cohort study in Denmark (Publications)
The International Agency for Research on Cancer has classified radiofrequency radiation as possibly carcinogenic. Previous studies have focused on intracranial tumors, although the skin receives much
Cynaropicrin targets the trypanothione redox system in <em>Trypanosoma brucei</em> (Publications)
In mice cynaropicrin (CYN) potently inhibits the proliferation of Trypanosoma brucei-the causative agent of Human African Trypanosomiasis-by a so far unknown mechanism. We hypothesized that CYNs ?,?-u
Synthesis and antiprotozoal activity of dicationic 2, 6-diphenylpyrazines and aza-analogues (Publications)
Dicationic 2,6-diphenylpyrazines, aza-analogues and prodrugs were synthesized; evaluated for DNA affinity, activity against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.)
Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane... (Publications)
Various natural products with the chromane and chromene scaffold exhibit high antiprotozoal activity. The natural product encecalin (7) served as key intermediate for the synthesis of different ethers
Improved characterization of visual evoked potentials in multiple sclerosis by topographic analysis (Publications)
In multiple sclerosis (MS), the combination of visual, somatosensory and motor evoked potentials (EP) has been shown to be highly correlated with the Expanded Disability Severity Scale (EDSS) and to p