Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant <em>Plasmodium falciparum</em>... (Publications)
Plasmodium falciparum, the most deadly malaria agent, displays a wide variety of resistance mechanisms in the field. The ability of antimalarial compounds in development to overcome these must therefo
The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data (Publications)
BACKGROUND: Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria, although treatment failures occur in some regions. We investigated the effect of dosing s
Long-term exposure to particulate matter constituents and the incidence of coronary events in 11 European cohorts (Publications)
BACKGROUND: Long-term exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity and mortality but little is known about the role of the chemical composition of PM
Low coverage of central point vaccination against dog rabies in Bamako, Mali (Publications)
Canine rabies remains an important public-health problem in Africa. Dog mass vaccination is the recommended method for rabies control and elimination. We report on the first small-scale mass dog vacci
The lipid-modifying enzyme SMPDL3B negatively regulates innate immunity (Publications)
Lipid metabolism and receptor-mediated signaling are highly intertwined processes that cooperate to fulfill cellular functions and safeguard cellular homeostasis. Activation of Toll-like receptors (TL
Using lung cancer mortality to indirectly approximate smoking patterns in space (Publications)
Smoking is the leading cause of lung cancer. Non-smoking factors have been associated with the disease. Existing Swiss survey data only capture the country partially and temporal coverage does not all
Antiviral innate immune activation in HIV infected adults negatively affects H1/IC31(R) induced vaccine-specific memory CD4+ T cells (Publications)
Tuberculosis (TB) remains a global health problem, with vaccination being a necessary strategy for disease containment and elimination. A TB vaccine should be safe and immunogenic as well as efficacio
Civil registration and vital statistics: progress in the data revolution for counting and accountability (Publications)
New momentum for civil registration and vital statistics (CRVS) is building, driven by the confluence of growing demands for accountability and results in health, improved equity, and rights-based app