Decline of ambient air pollution levels and improved respiratory health in Swiss children (Publications)
decline = 0.65, 95% confidence interval (CI), 0.54-0.79], bronchitis (OR = 0.66; 95% CI, 0.55-0.80), common cold (OR = 0.78; 95% CI, 0.68-0.89), nocturnal dry cough (OR = 0.70; 95% CI, 0.60-0.83), and [...] conjunctivitis symptoms (OR = 0.81; 95% CI, 0.70-0.95). Changes in prevalence of sneezing during pollen season, asthma, and hay fever were not associated with the PM(subscript)10(/subscript) reduction
The effect of cyclin D1 (CCND1) G870A-polymorphism on breast cancer risk is modified by oxidative stress among Chinese women in Singapore (Publications)
antagonistic marine n-3 fatty acids (OR=0.54, 95% CI 0.32-0.93) or a total lack of the antioxidative GSTM1 (OR=0.44, 95% CI 0.25-0.80) or GSTT1 genes (OR=0.46, 95% CI 0.24-0.87). The effects were consistently [...] subjects (OR=0.67, 95% CI 0.45-0.99) when compared with the GG genotype. The association was restricted to women with a high (above median value) intake level of n-6 fatty acids (OR=0.51, 95% CI 0.30-0.87), a
Opposite effect of negative and positive affect on stress procoagulant reactivity (Publications)
activity (p values < 0.05). VWF:Ag reactivity showed inverse relationships with exhaustion (r = -0.63, p < 0.001), negative affectivity (r = -0.53, p = 0.005), and worrying (r = -0.53, p = 0.005). Exhaustion [...] Fibrinogen reactivity showed inverse relationships with negative affectivity (r = -0.59, p = 0.002) and anxiety (r = -0.54, p = 0.005); negative affectivity emerged as an independent predictor of fibrinogen [...] and FVII:C reactivity were also correlated (r = -0.52, p = 0.006)....
Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with <em>Opisthorchis... (Publications)
reduction-rate ratio 1.61, 95% CI 0.21-0.72), 31.5% for artesunate (0.43, 0.23-0.80), 41.3% for mefloquine-artesunate (0.60, 0.31-1.10), and 99.3% for tribendimidine (1.00, 0.44-2.30). Most adverse events [...] mefloquine, one with artesunate (odds ratio 0.03, 95% CI 0.004-0.29), one with mefloquine-artesunate (0.03, 0.004-0.29), and 19 with tribendimidine (1.87, 0.60-5.85). Egg reduction rate was 98.4% for
Clinical sign and biomarker-based algorithm to identify bacterial pneumonia among outpatients with lower respiratory tract infection in Tanzania (Publications)
(AUROC 0.88, 95%CI 0.78-0.98; 0.84, 0.72-0.99; 0.83, 0.74-0.92, respectively). Combining respiratory rate with PCT or IL-6 significantly improved the model compared to respiratory rate alone (p = 0.006, [...] p = 0.033, respectively). An algorithm with respiratory rate (> /= 32/min) and PCT (> /= 0.25 mug/L) had 94% sensitivity and 82% specificity. CONCLUSIONS: PCT, IL-6 and sTREM-1 had an excellent predictive
Childhood cancer and nuclear power plants in Switzerland: a census-based cohort study (Publications)
leukaemia at ages 0-4 and 0-15 years, and 18 and 31 children diagnosed with any cancer were born 15 km away, the IRRs (95% CI) for leukaemia in 0-4 and 0-15 year olds were 1.20 (0.60-2.41) and 1.05 (0.60-1.86) [...] y. For any cancer, corresponding IRRs were 0.97 (0.61-1.54) and 0.89 (0.63-1.27). There was no evidence of a dose-response relationship with distance (P > 0.30). Results were similar for residence at diagnosis [...] or any childhood cancer in Switzerland. METHODS: We computed...
Clinical sign and biomarker-based algorithm to identify bacterial pneumonia among outpatients with lower respiratory tract infection in Tanzania (Publications)
(AUROC 0.88, 95%CI 0.78-0.98; 0.84, 0.72-0.99; 0.83, 0.74-0.92, respectively). Combining respiratory rate with PCT or IL-6 significantly improved the model compared to respiratory rate alone (p = 0.006, [...] p = 0.033, respectively). An algorithm with respiratory rate (> /= 32/min) and PCT (> /= 0.25 mug/L) had 94% sensitivity and 82% specificity. CONCLUSIONS: PCT, IL-6 and sTREM-1 had an excellent predictive
Childhood cancer and nuclear power plants in Switzerland: a census-based cohort study (Publications)
leukaemia at ages 0-4 and 0-15 years, and 18 and 31 children diagnosed with any cancer were born 15 km away, the IRRs (95% CI) for leukaemia in 0-4 and 0-15 year olds were 1.20 (0.60-2.41) and 1.05 (0.60-1.86) [...] y. For any cancer, corresponding IRRs were 0.97 (0.61-1.54) and 0.89 (0.63-1.27). There was no evidence of a dose-response relationship with distance (P > 0.30). Results were similar for residence at diagnosis [...] or any childhood cancer in Switzerland. METHODS: We computed...
Correlates and outcomes of posttransplant smoking in solid organ transplant recipients: a systematic literature review and meta-analysis (Publications)
smoke (OR 0.48, 95%CI 0.38-0.62), as were patients with a higher Body Mass Index (BMI)(OR 0.68, 95%CI 0.52-0.89). Hypertension (OR 1.16, 95%CI 0.77-1.75), Diabetes Mellitus (OR 0.52, 95%CI 0.15-1.78) and [...] 02-1.95), nonskin malignancies (OR 2.58, 95%CI 1.26-5.29), a shorter patient survival time (OR 0.59, 95%CI 0.44-0.79) and higher odds of mortality (OR 1.74, 95%CI 1.21-2.48). CONCLUSION: Posttransplant smoking [...] and having a history of cardiovascular disease (OR 0.92, 95%CI 0.77-1.09)...
Markers of environmental enteric dysfunction are associated with poor growth and developmental outcomes among young children in Lusaka, Zambia (Publications)
lower HAZ (β: -0.21, 95% CI: -0.41, -0.01 and β: -0.20, 95% CI: -0.32, -0.08, respectively). Higher I-FABP concentrations were significantly associated with lower DAZ (β: -0.22, 95% CI: -0.40, -0.03) and slower [...] 12.72) as were higher alpha-1-acid glycoprotein concentrations (HAZ β: -0.38, 95% CI: -0.72, -0.03; SRT β: 11.14 ms, 95% CI: 0.94, 21.72). CONCLUSIONS: In children in Lusaka, biomarkers of EED were associated [...] anthropometric (height-for-age z-score [HAZ], weight-for-height...
