A polymorphism in CD14 modifies the effect of farm milk consumption on allergic diseases and CD14 gene expression (Publications)
between farm milk and asthma varied between the genotypes: AA, 0.18 (95% CI, 0.07-0.47); AG, 0.47 (95% CI, 0.26-0.86); and GG, 0.98 (95% CI, 0.46-2.08). Similar patterns were observed for symptoms of allergic [...] gene expression (adjusted geometric means ratios: AA, 1.61 (95% CI, 0.98-2.66); AG, 1.11 (95% CI, 0.71-1.72); and GG, 0.76 (95% CI, 0.39-1.48). CONCLUSION: The protective effect of farm milk consumption
Puberty and microvascular function in healthy children and adolescents (Publications)
14 (3.0) years and a mean body mass index of 19.0 +/- 3.63 kg m(-2). Significant correlations with RHI were observed for Tanner stage (r = 0.569; P < .001), age (r = 0.567; P < .001), stature (r = 0.553; [...] function (R(2) = 0.242; beta = 0.492; P < .001). Prepubertal children (group 1) had a significantly lower RHI [1.14 (0.24)] compared with group 2 [1.65 (0.57)] and group 3 [1.70 (0.75)] (all P < .001) [...] 553; P < .001), systolic blood pressure (r = 0.4941; P < .001), and body mass...
Different contribution of interleukin-6 and cortisol activity to total plasma fibrin concentration and to acute mental stress-induced fibrin formation (Publications)
activity (R2 = 0.33, P = 0.007) and total cortisol activity (DeltaR2 = 0.17, P = 0.034) explained 50% of the variance in total D-dimer activity. Stress-induced changes in fibrinogen (R2 = 0.47, P = 0.001) and [...] entire 2-h period and of stress reactivity of proteins. IL-6 (P < 0.001), fibrinogen (P = 0.001), D-dimer (P = 0.021) and cortisol (P < 0.001) had all significantly changed across the four time points assessed [...] and IL-6 (DeltaR2 = 0.18, P = 0.008) together explained 65% of the...
Short course amphotericin B in addition to sertraline and fluconazole for treatment of HIV-associated cryptococcal meningitis in rural Tanzania (Publications)
respectively (p=0.012). The cerebrospinal fluid (CSF) Cryptococcus clearance rate was 0.264 log10 colony forming units (CFU)/mL of CSF/day (95%CI: 0.112-0.416) without amphotericin and 0.473 log10 CFU/mL/day [...] CFU/mL/day (95%CI: 0.344-0.60) with short-course amphotericin (p=0.03). Sertraline was discontinued in one participant due to side effects. Four participants receiving amphotericin B experienced hypokalemia [...] 1200 mg/day (n=28) vs. sertraline, fluconazole and additional 5-days of...
Associations between natural resource extraction and incidence of acute and chronic health conditions: evidence from Tanzania (Publications)
diseases, including chronic diseases (IRR = 0.61, CI: 0.47–0.80), mental health disorders (IRR = 0.66, CI: 0.47–0.92), and undernutrition (IRR = 0.69, CI: 0.55–0.88). Extraction of construction materials
Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors (Publications)
Prediction by family history of asthma and atopy yielded an area under the ROC curve (AUC) of 0.62 [0.57-0.66] in the random forest machine learning approach. By adding information on demographics (sex [...] and 26 environmental exposure variables, the quality of prediction significantly improved (AUC=0.65 [0.61-0.70]). In farm children, however, environmental variables did not improve prediction quality. Rather [...] Rather SNPs related to IL33 and RAD50 contributed significantly to the...
Prediction of MS disability by multimodal evoked potentials: investigation during relapse or in the relapse-free interval? (Publications)
0 for Group 1 and 1.5 for Group 2. Mean disease durations were 2.0 and 2.8years, respectively. Median EDSST2 was 2.0 for both groups. The s-EP-QT0 significantly predicted EDSST2 (R2=0.47) for patients [...] baseline (T0) and year 3 (T2). Linear regression analysis was performed to examine the association between EDSST2 and a baseline EP compound measure (s-EP-QT0) for each group. RESULTS: Median EDSST0 was 3.0 [...] patients in Group 2, but not for patients in Group 1 (R2=0.07). CONCLUSION: In...
Socioeconomic status and adherence to preventive measures during the COVID-19 pandemic in Switzerland: a population based digital cohort analysis (Publications)
to participants in the first (low) quartile [second (Adj.OR, 95% CI) (0.56, 0.37-0.85), third (0.38, 0.23-0.64), fourth (0.60, 0.36-0.98)]. We observed similar results for education. CONCLUSION: No differences
Socioeconomic status and adherence to preventive measures during the COVID-19 pandemic in Switzerland: a population based digital cohort analysis (Publications)
to participants in the first (low) quartile [second (Adj.OR, 95% CI) (0.56, 0.37-0.85), third (0.38, 0.23-0.64), fourth (0.60, 0.36-0.98)]. We observed similar results for education. CONCLUSION: No differences
Associations between natural resource extraction and incidence of acute and chronic health conditions: evidence from Tanzania (Publications)
diseases, including chronic diseases (IRR = 0.61, CI: 0.47–0.80), mental health disorders (IRR = 0.66, CI: 0.47–0.92), and undernutrition (IRR = 0.69, CI: 0.55–0.88). Extraction of construction materials
