Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors (Publications)
Prediction by family history of asthma and atopy yielded an area under the ROC curve (AUC) of 0.62 [0.57-0.66] in the random forest machine learning approach. By adding information on demographics (sex [...] and 26 environmental exposure variables, the quality of prediction significantly improved (AUC=0.65 [0.61-0.70]). In farm children, however, environmental variables did not improve prediction quality. Rather [...] Rather SNPs related to IL33 and RAD50 contributed significantly to the...
Prediction of MS disability by multimodal evoked potentials: investigation during relapse or in the relapse-free interval? (Publications)
0 for Group 1 and 1.5 for Group 2. Mean disease durations were 2.0 and 2.8years, respectively. Median EDSST2 was 2.0 for both groups. The s-EP-QT0 significantly predicted EDSST2 (R2=0.47) for patients [...] baseline (T0) and year 3 (T2). Linear regression analysis was performed to examine the association between EDSST2 and a baseline EP compound measure (s-EP-QT0) for each group. RESULTS: Median EDSST0 was 3.0 [...] patients in Group 2, but not for patients in Group 1 (R2=0.07). CONCLUSION: In...
Short course amphotericin B in addition to sertraline and fluconazole for treatment of HIV-associated cryptococcal meningitis in rural Tanzania (Publications)
respectively (p=0.012). The cerebrospinal fluid (CSF) Cryptococcus clearance rate was 0.264 log10 colony forming units (CFU)/mL of CSF/day (95%CI: 0.112-0.416) without amphotericin and 0.473 log10 CFU/mL/day [...] CFU/mL/day (95%CI: 0.344-0.60) with short-course amphotericin (p=0.03). Sertraline was discontinued in one participant due to side effects. Four participants receiving amphotericin B experienced hypokalemia [...] 1200 mg/day (n=28) vs. sertraline, fluconazole and additional 5-days of...
A novel electronic algorithm using host biomarker point-of-care tests for the management of febrile illnesses in Tanzanian children (e-POCT): a... (Publications)
ratio [RR] 0.57, 95% CI 0.38, 0.85, p = 0.005). The proportion of severe adverse events was 0.6% in the e-POCT arm compared with 1.5% in the ALMANACH arm (RR 0.42, 95% CI 0.20, 0.87, p = 0.02). The proportion [...] on day 0, and 1.1% (6/544) experienced severe adverse events. e-POCT achieved a 49% reduction in the relative risk of clinical failure compared to routine care (RR 0.51, 95% CI 0.31, 0.84, p = 0.007) and [...] proportion of antibiotic prescriptions was substantially lower, 11.5%...
A novel electronic algorithm using host biomarker point-of-care tests for the management of febrile illnesses in Tanzanian children (e-POCT): a... (Publications)
ratio [RR] 0.57, 95% CI 0.38, 0.85, p = 0.005). The proportion of severe adverse events was 0.6% in the e-POCT arm compared with 1.5% in the ALMANACH arm (RR 0.42, 95% CI 0.20, 0.87, p = 0.02). The proportion [...] on day 0, and 1.1% (6/544) experienced severe adverse events. e-POCT achieved a 49% reduction in the relative risk of clinical failure compared to routine care (RR 0.51, 95% CI 0.31, 0.84, p = 0.007) and [...] proportion of antibiotic prescriptions was substantially lower, 11.5%...
Exposure assessment to dust and free silica for workers of Sangan iron ore mine in Khaf, Iran (Publications)
26 +/- 3 and 0.01 +/- 0.005 mg/m(3), respectively. Considerate to Iranian standard for respirable dust concentrations (0.11 mg/m(3)) and international standards (ACGIH = 0.1 and NIOSH = 0.05 mg/m(3)), [...] +/- 2 and 0.012 +/- 0.002 mg/m(3), respectively. Also, the maximum concentrations of respirable dust and free silica were measured in Tappeh Ghermez drilling no. 1 at 66 +/- 13 and 1.5 +/- 0.4 mg/m(3)
Exposure assessment to dust and free silica for workers of Sangan iron ore mine in Khaf, Iran (Publications)
26 +/- 3 and 0.01 +/- 0.005 mg/m(3), respectively. Considerate to Iranian standard for respirable dust concentrations (0.11 mg/m(3)) and international standards (ACGIH = 0.1 and NIOSH = 0.05 mg/m(3)), [...] +/- 2 and 0.012 +/- 0.002 mg/m(3), respectively. Also, the maximum concentrations of respirable dust and free silica were measured in Tappeh Ghermez drilling no. 1 at 66 +/- 13 and 1.5 +/- 0.4 mg/m(3)
Variability of the human serum metabolome over 3 months in the EXPOsOMICS Personal Exposure Monitoring study (Publications)
across all metabolic features was 0.51 (IQR: 0.29) and 0.64 (IQR: 0.25) for the 184 uniquely identified compounds. For this group, the median ICC marginally changed (0.63) when we included common confounders [...] ICC was largest among glycerophospholipids (median ICC 0.70) and steroids (0.67), and lowest for amino acids (0.61) and the O-acylcarnitine class (0.44). ICCs varied substantially within chemical classes [...] Our results suggest that the metabolome as measured with untargeted LC-HRMS...
Prevalence and risk factors of <em>Strongyloides stercoralis</em> in Takeo Province, Cambodia (Publications)
CI: 1.4 - 2.0; P < 0.001). Participants who had a latrine at home were significantly less frequently infected with S. stercoralis than those who did not (OR: 0.7; 95% CI: 0.4 - 0.8; P = 0.003). Muscle [...] Muscle pain (OR: 1.3; 95% CI: 1.0 - 1.6; P = 0.028) and urticaria (OR: 1.4; 95% CI: 1.1 - 1.8; P = 0.001) were significantly associated with S. stercoralis infection. CONCLUSIONS: S. stercoralis is highly prevalent [...] RESULTS: Eight intestinal helminth species were diagnosed. Hookworm...
Effects of a lifestyle intervention on adiposity and fitness in overweight or low fit preschoolers (Ballabeina) (Publications)
interaction = 0.001) and low fit children (n = 154) more beneficial effects on all adiposity outcomes (p for interaction /=0.2). Average intervention effect sizes for BMI were -0.12, -0.05, -0.26 and -0.02 kg/m2 [...] kg/m2 and for aerobic fitness were 0.40, 0.30, 0.12 and 0.36 stages for OW, normal weight, low fit and normal fit children, respectively. Conclusions: This multidimensional intervention was equally and for
