Geographical variations of the associations between health interventions and all-cause under-five mortality in Uganda (Publications)
(HRR) = 0.60; 95% Bayesian credible interval (BCI): 0.11, 0.79), initiation of breastfeeding within 1 h of birth (HR = 0.70; 95% BCI: 0.51, 0.86), intermittent preventive treatment (IPTp) (HRR = 0.74; 95% [...] 95% BCI: 0.67, 0.97) and access to insecticide-treated nets (ITN) (HRR = 0.75; 95% BCI: 0.63, 0.84). In Central 2, Mid-Western and South-West, largest reduction in U5M was associated with access to ITNs
Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the Global Burden of Disease Study 2019 (Publications)
an AAPC of 0.68 and the ASR decreased with an AAPC of -0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while [...] while the ASR of asthma (AAPC = -0.41), inflammatory bowel disease (AAPC = -0.72), multiple sclerosis (AAPC = -0.26), psoriasis (AAPC = -0.77), and atopic dermatitis (AAPC = -0.15) decreased. The ASR of overall [...] multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%,...
Mortality risk attributable to wildfire-related PM2.5 pollution: a global time series study in 749 locations (Publications)
013-1.025) for respiratory mortality. Overall, 0.62% (95% CI 0.48-0.75) of all-cause deaths, 0.55% (0.43-0.67) of cardiovascular deaths, and 0.64% (0.50-0.78) of respiratory deaths were annually attributable [...] ed PM2.5 were estimated using the three-dimensional chemical transport model GEOS-Chem at a 0.25 degrees x 0.25 degrees resolution. The association between wildfire-related PM2.5 exposure and mortality [...] pooled RRs of mortality associated with each 10 mug/m(3) increase in the 3-day...
The shape of the iceberg: quantification of submicroscopic <em>Plasmodium falciparum</em> and<em> Plasmodium vivax </em>parasitaemia and... (Publications)
slides (0.7%), 107 of 845 blood samples (12.7%) were parasite positive by (DNA-based) qPCR. qPCR parasite prevalence between sites and surveys ranged from 3.8 to 19.0% for P. falciparum and 0.0 to 9.0% for [...] parasite densities for both P. falciparum (correlation coefficient = 0.83, p = 0.010) and P. vivax (correlation coefficient = 0.58, p = 0.010). Antibody titers against P. falciparum AMA-1 and MSP-119 were [...] vivax. The median density of P. falciparum infections (n = 85) was 24.4...
Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the Global Burden of Disease Study 2019 (Publications)
an AAPC of 0.68 and the ASR decreased with an AAPC of -0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while [...] while the ASR of asthma (AAPC = -0.41), inflammatory bowel disease (AAPC = -0.72), multiple sclerosis (AAPC = -0.26), psoriasis (AAPC = -0.77), and atopic dermatitis (AAPC = -0.15) decreased. The ASR of overall [...] multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%,...
Mortality risk attributable to wildfire-related PM2.5 pollution: a global time series study in 749 locations (Publications)
013-1.025) for respiratory mortality. Overall, 0.62% (95% CI 0.48-0.75) of all-cause deaths, 0.55% (0.43-0.67) of cardiovascular deaths, and 0.64% (0.50-0.78) of respiratory deaths were annually attributable [...] ed PM2.5 were estimated using the three-dimensional chemical transport model GEOS-Chem at a 0.25 degrees x 0.25 degrees resolution. The association between wildfire-related PM2.5 exposure and mortality [...] pooled RRs of mortality associated with each 10 mug/m(3) increase in the 3-day...
The shape of the iceberg: quantification of submicroscopic <em>Plasmodium falciparum</em> and<em> Plasmodium vivax </em>parasitaemia and... (Publications)
slides (0.7%), 107 of 845 blood samples (12.7%) were parasite positive by (DNA-based) qPCR. qPCR parasite prevalence between sites and surveys ranged from 3.8 to 19.0% for P. falciparum and 0.0 to 9.0% for [...] parasite densities for both P. falciparum (correlation coefficient = 0.83, p = 0.010) and P. vivax (correlation coefficient = 0.58, p = 0.010). Antibody titers against P. falciparum AMA-1 and MSP-119 were [...] vivax. The median density of P. falciparum infections (n = 85) was 24.4...
Geographical variations of the associations between health interventions and all-cause under-five mortality in Uganda (Publications)
(HRR) = 0.60; 95% Bayesian credible interval (BCI): 0.11, 0.79), initiation of breastfeeding within 1 h of birth (HR = 0.70; 95% BCI: 0.51, 0.86), intermittent preventive treatment (IPTp) (HRR = 0.74; 95% [...] 95% BCI: 0.67, 0.97) and access to insecticide-treated nets (ITN) (HRR = 0.75; 95% BCI: 0.63, 0.84). In Central 2, Mid-Western and South-West, largest reduction in U5M was associated with access to ITNs
Quantitative evaluation of a handheld light microscope for field diagnosis of soil-transmitted helminth infection (Publications)
the two devices was excellent for both species (kappa = 0.90, 95% confidence interval = 0.82-0.99 for A. lumbricoides and kappa = 0.96, 95% CI = 0.91-1.00 for T. trichiura). The Newton Nm1 microscope may [...] higher with the conventional light microscope (5,190.0 EPG versus 2,385.8 EPG for Ascaris lumbricoides; 826.3 versus 455.7 for Trichuris trichiura; both P < 0.05). Using regression coefficients and accounting
In vitro susceptibility of <em>P. falciparum</em> populations from Colombia and Tanzania to a new synthetic peroxide (OZ277) (Publications)
2.5 ng/mL [0.34-8] (4.4 nM [0.6-14]) and Tanzania with 1.5 ng/mL [0.22-10] (2.65 nM [0.4-17.7]). The potency of OZ277 was similar to artesunate, showing median IC(50) values of 1.5 ng/mL [0.42-8.6] (3 [...] (3.8 nM [1.1-22.3]) and 1.8 ng/mL [0.2-10] (4.7 nM [0.5-26.04]) in Colombia and Tanzania, respectively. These results support the development of this new antimalarial compound
