Immune deficiency in mouse models for inherited peripheral neuropathies leads to improved myelin maintenance (Publications)
ing gene cause hereditary demyelinating neuropathies. In mice heterozygously deficient in P(0) (P(0)(+/-) mice), an established animal model for a subtype of hereditary neuropathies, T-lymphocytes are [...] pathology, we cross-bred P(0)(+/-) mice with null mutants for the recombination activating gene 1 (RAG-1) or with mice deficient in the T-cell receptor alpha-subunit. We found that in P(0)(+/-) mice myelin d [...] is deficient. Moreover, isolated T-lymphocytes from P(0)(+/-) mice show...
Quantitative evaluation of a handheld light microscope for field diagnosis of soil-transmitted helminth infection (Publications)
the two devices was excellent for both species (kappa = 0.90, 95% confidence interval = 0.82-0.99 for A. lumbricoides and kappa = 0.96, 95% CI = 0.91-1.00 for T. trichiura). The Newton Nm1 microscope may [...] higher with the conventional light microscope (5,190.0 EPG versus 2,385.8 EPG for Ascaris lumbricoides; 826.3 versus 455.7 for Trichuris trichiura; both P < 0.05). Using regression coefficients and accounting
In vitro susceptibility of <em>P. falciparum</em> populations from Colombia and Tanzania to a new synthetic peroxide (OZ277) (Publications)
2.5 ng/mL [0.34-8] (4.4 nM [0.6-14]) and Tanzania with 1.5 ng/mL [0.22-10] (2.65 nM [0.4-17.7]). The potency of OZ277 was similar to artesunate, showing median IC(50) values of 1.5 ng/mL [0.42-8.6] (3 [...] (3.8 nM [1.1-22.3]) and 1.8 ng/mL [0.2-10] (4.7 nM [0.5-26.04]) in Colombia and Tanzania, respectively. These results support the development of this new antimalarial compound
Immune deficiency in mouse models for inherited peripheral neuropathies leads to improved myelin maintenance (Publications)
ing gene cause hereditary demyelinating neuropathies. In mice heterozygously deficient in P(0) (P(0)(+/-) mice), an established animal model for a subtype of hereditary neuropathies, T-lymphocytes are [...] pathology, we cross-bred P(0)(+/-) mice with null mutants for the recombination activating gene 1 (RAG-1) or with mice deficient in the T-cell receptor alpha-subunit. We found that in P(0)(+/-) mice myelin d [...] is deficient. Moreover, isolated T-lymphocytes from P(0)(+/-) mice show...
Exposure modeling of high-frequency electromagnetic fields (Publications)
was 0.67 (95% confidence interval (CI): 0.33-0.86) in the city of Basel and 0.77 (95% CI: 0.46-0.91) in the rural area. In both regions, kappa coefficients between measurements and modeling were 0.63 and [...] and 0.77 for the total HF-EMF strengths and for all mobile phone frequency bands. First evaluation of our geospatial model yielded substantial agreement between modeling and measurements. However, before
Molecular epidemiology and genetic diversity of disappearing <em>Plasmodium vivax</em> in southern Thailand (Publications)
diversity in Yala was relatively low (π = 0.008(dbp) and 0.014(msp1); Hd = 0.774(dbp) and 0.407(msp1)) compared to Tak (π = 0.012(dbp) and 0.027(msp1); Hd = 0.849(dbp) and 0.962(msp1)). In Yala, polyclonal infections
Exposure modeling of high-frequency electromagnetic fields (Publications)
was 0.67 (95% confidence interval (CI): 0.33-0.86) in the city of Basel and 0.77 (95% CI: 0.46-0.91) in the rural area. In both regions, kappa coefficients between measurements and modeling were 0.63 and [...] and 0.77 for the total HF-EMF strengths and for all mobile phone frequency bands. First evaluation of our geospatial model yielded substantial agreement between modeling and measurements. However, before
Breastfeeding, physical growth, and cognitive development (Publications)
associated with a 0.4-SD increase in overall child development (beta: .38; confidence limit = 0.23 to 0.53), a 0.6-SD increase in height-for-age z score (beta: .55; confidence limit = 0.31 to 0.79), and a 67% [...] 67% decrease in the odds of stunting (odds ratio = 0.33; 95% confidence interval = 0.20 to 0.54). CONCLUSIONS: Our results suggest that even in settings with easy access to complementary foods, complying
Apathy in Parkinson's disease is related to executive function, gender and age but not to depression (Publications)
model (R (2) = 0.41; p < 0.01) revealed influences of initiation (b = -0.79; p < 0.01), gender (b = -7.75; p < 0.01), age (b = -0.07; p < 0.05) and an age by gender interaction (b = 0.12; p < 0.01) on apathy
Response to [90Yttrium-DOTA]-TOC treatment is associated with long-term survival benefit in metastasized medullary thyroid cancer: a phase II clinical... (Publications)
diagnosis (hazard ratio, 0.20; 95% confidence interval, 0.05-0.81; P = 0.02) and from time of first [(90)Y-DOTA]-TOC therapy (hazard ratio, 0.16; 95% confidence interval, 0.04-0.63; P = 0.009). The visual grade [...] (range, 1.7-29.6 GBq) of [(90)Y-DOTA]-TOC was administered. Response was found in nine patients (29.0%). Four patients (12.9%) developed hematologic toxicities and seven patients (22.6%) developed renal
