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1. Lack of associations of alpha(+) - thalassemia with the risk of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infection and disease in... (Publications)

   Lack of associations of alpha(+) - thalassemia with the risk of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infection and disease in a cohort of children aged 3-21 months from Papua New Guinea

   Relevance:

   = 1.13, CI(95) (0.82,1.56), P = 0.45, Pv: IRR = 1.15, CI(95) (0.9881.56), P = 0.31), heterozygote (Pf: IRR = 0.98, CI(95) (0.71,1.34), P = 0.93, Pv: IRR = 1.14, CI(95) (0.88,1.48), P =0.33) and wild-type [...] 112 Papua New Guinean children, followed from 3-21 months of age. Three hundred and eighty-nine (35.0%) children were homozygous for a(+)-thalassemia (-a/-a), 506 (45.5%) heterozygous (aa/-a) and 217 (19 [...] g/dl) was observed in alpha(+)-thalassemia homozygote children (IRR = 1.54,...

2. Joint effect of heat and air pollution on mortality in 620 cities of 36 countries (Publications)

   Joint effect of heat and air pollution on mortality in 620 cities of 36 countries

   Relevance:

   Corresponding mortality estimate for O3 across these temperature percentiles were 0.00% (-0.44%, 0.44%) and 0.53% (0.38%, 0.68%). Similar effect modification results, although slightly weaker, were found [...] 18.5%), respectively. Similarly, a 10 μg/m3 increment in PM10 was associated with a 0.54% (0.10%, 0.98%) and 1.21% (0.69%, 1.72%) increase in mortality when daily air temperature was set to the 1st and [...] interval: 7.1%, 10.7%) mortality increment, ranging between 5.3% (3.8%, 6.9%) and...

3. Associations between modeled residential outdoor and measured personal exposure to ultrafine particles in four European study areas (Publications)

   Associations between modeled residential outdoor and measured personal exposure to ultrafine particles in four European study areas

   Relevance:

   l outdoor versus personal exposure were smaller for UFP (0.16 ± 0.04) than for simultaneously measured PM2.5 and soot (0.32 ± 0.10 and 0.43 ± 0.06). Our findings provide some support for the use of LUR [...] mean personal exposures. Regression slopes (±se) combined for the four areas were 0.12 ± 0.04 for median and −0.06 ± 0.17 for mean personal exposure. The LUR model explained variance of the median personal

4. Monitoring <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> using microsatellite markers indicates limited changes in population structure... (Publications)

   Monitoring <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> using microsatellite markers indicates limited changes in population structure after substantial transmission decline in Papua New Guinea

   Relevance:

   Pf=38.0-9.0%, Pv: 31.8-19.7%), genetically diverse and intermixing parasite populations remained. Pf diversity declined modestly post-LLIN relative to pre-LLIN (East Sepik: Rs = 7.1-6.4, He = 0.77-0.71; [...] diversity remained high throughout the study period (East Sepik: Rs =11.4-9.3, He =0.83-0.80; Madang: Rs =12.2-14.5, He =0.85-0.88). Although genetic differentiation values increased between provinces over [...] 71; Madang: Rs = 8.2-6.1, He = 0.79-0.71). Unexpectedly, population structure...

5. Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients (Publications)

   Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients

   Relevance:

   daily fall in log cfu/mL of sputum (95% CI) was 0.093 (0.126-0.059) with rifampicin, 0.133 (0.166-0.100) with rifampicin plus 150 mg of SQ109 and 0.089 (0.121-0.057) with rifampicin plus 300 mg of SQ109. [...] prolongation was noted. Maximum SQ109 plasma concentrations were lower than MICs. Exposure to SQ109 (AUC0-24) increased by drug accumulation upon repeated administration in the SQ109 monotherapy groups. Co

6. Ziehl-neelsen staining technique can diagnose paragonimiasis (Publications)

   Ziehl-neelsen staining technique can diagnose paragonimiasis

   Relevance:

   WF technique was 84.6 (p = 0.48), 76.9 (p = 0.25) and 61.5% (p = 0.07), respectively. Percentage of fragmented eggs was below 19% and did not differ between techniques (p = 0.13). Additional operational [...] costs per slide were 0 (ZNS), 0.10 US$ (WF), and 0.79 US$ (FECT). ZNS heated for five minutes contained less eggs than briefly heated slides (29 eggs per slide [eps] vs. 42 eps, p = 0.01). Bloodstained sputum [...] sputum portions contained more eggs than unstained parts (3.3 eps vs. 0.7...

7. Signatures of transmission in within-host <em>M. tuberculosis</em> variation (Publications)

   Signatures of transmission in within-host <em>M. tuberculosis</em> variation

   Relevance:

   all three studies as compared to models without within-host variation (AUC: 0.95 versus 0.92, 0.99 versus 0.95, and 0.93 versus 0.91). INTERPRETATION: Within-host M. tuberculosis variation persists through [...] from unlinked individuals in the three studies (mean 98 shared minority variants vs. 10; 0.8 vs. 0.2, and 0.7 vs. 0.2, respectively). Shared within-host variation was significantly associated with household

8. Signatures of transmission in within-host <em>M. tuberculosis</em> variation (Publications)

   Signatures of transmission in within-host <em>M. tuberculosis</em> variation

   Relevance:

   all three studies as compared to models without within-host variation (AUC: 0.95 versus 0.92, 0.99 versus 0.95, and 0.93 versus 0.91). INTERPRETATION: Within-host M. tuberculosis variation persists through [...] from unlinked individuals in the three studies (mean 98 shared minority variants vs. 10; 0.8 vs. 0.2, and 0.7 vs. 0.2, respectively). Shared within-host variation was significantly associated with household

9. Monitoring <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> using microsatellite markers indicates limited changes in population structure... (Publications)

   Monitoring <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> using microsatellite markers indicates limited changes in population structure after substantial transmission decline in Papua New Guinea

   Relevance:

   Pf=38.0-9.0%, Pv: 31.8-19.7%), genetically diverse and intermixing parasite populations remained. Pf diversity declined modestly post-LLIN relative to pre-LLIN (East Sepik: Rs = 7.1-6.4, He = 0.77-0.71; [...] diversity remained high throughout the study period (East Sepik: Rs =11.4-9.3, He =0.83-0.80; Madang: Rs =12.2-14.5, He =0.85-0.88). Although genetic differentiation values increased between provinces over [...] 71; Madang: Rs = 8.2-6.1, He = 0.79-0.71). Unexpectedly, population structure...

10. Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients (Publications)

    Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients

    Relevance:

    daily fall in log cfu/mL of sputum (95% CI) was 0.093 (0.126-0.059) with rifampicin, 0.133 (0.166-0.100) with rifampicin plus 150 mg of SQ109 and 0.089 (0.121-0.057) with rifampicin plus 300 mg of SQ109. [...] prolongation was noted. Maximum SQ109 plasma concentrations were lower than MICs. Exposure to SQ109 (AUC0-24) increased by drug accumulation upon repeated administration in the SQ109 monotherapy groups. Co