<em>In vitro</em> and<em> in vivo</em> activity of R- and S-praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel... (Publications)
dose of 250.0 mg/kg PZQ resulted in a WBR of 99.3%. S-PZQ was highly active in vivo at 250.0 and 500.0 mg/kg with WBRs of 83.0 and 94.1%, respectively. The lowest tested dose of S-PZQ, 125.0 mg/kg, showed [...] IC50 of 0.03 mug/ml and 1.47 mug/ml both at 4 and 72 h, respectively. In vivo, R-PZQ was the most potent drug with worm burden reductions (WBRs) of 98.5, 75.6 and 73.3% at 125.0, 62.5 and 31.0 mg/kg, [...] R-PZQ displayed the highest activity against adult worms in vitro, revealing an...
Dietary magnesium, vitamin D, and animal protein intake and their association to the linear growth trajectory of children from birth to 24 months of... (Publications)
with the linear growth trajectory. We also found that birth weight (beta = 0.91, P < .01), treating water (beta = 0.35, P < 0.00), and maternal height (beta = 3.4, P < .00) were positively associated with [...] association with the slope (beta = -0.39, P < .01; beta = 0.08, P < .04), respectively. Conversely, birth weight had negative association with the slope (beta = -0.12, P < .01). CONCLUSIONS: Dietary magnesium [...] positively associated (coefficient beta = 0.006, P < .02) with LAZ at 12...
Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries (Publications)
was 0.26% (95% confidence interval 0.24% to 0.28%), corresponding to 8203 annual excess deaths (95% confidence interval 3525 to 12 840) across the 406 cities studied. The excess remained at 0.20% (0.18% [...] Europe, America, and China, excess mortality was 0.14%, 0.09%, and 0.05%, respectively. CONCLUSIONS: Results suggest that ozone related mortality could be potentially reduced under stricter air quality [...] 18% to 0.22%) when restricting to days above the WHO guideline (100 microg/m(3)),...
Prevalence, awareness, treatment and control of high blood pressure in a cohort in Northern Andean Peru (Publications)
08-1.24), and decreased with healthier lifestyle score (OR: 0.93, CI: 0.91-0.95). Unawareness of HBP was lower among women (OR: 0.56, CI: 0.38-0.83), higher among participants living over 3000 m Above Sea [...] Sea Level (OR: 1.15, CI: 1.03-1.27) and decreased with age (OR: 0.99, CI: 0.98-0.99). CONCLUSIONS: Unawareness of HBP was high, few HTN patients received treatment and BP remained high in the presence of
Gender differences in the provision of intensive care: a Bayesian approach (Publications)
aged > 65 years (OR women:men 0.94 (0.89-0.99), p < 0.001). Women < 45 years had a similar ICU admission probability as men in the same age category [OR women:men 1.03 (0.94-1.13)], in spite of more severe [...] years in men, p < 0.001]. Overall, women had a lower likelihood to be admitted to an intensive care unit (ICU) than men, despite being more severely ill [odds ratio (OR) 0.78 (0.76-0.79)]. ICU admission
The use of morbidity questionnaires to identify communities with high prevalence of geohelminth infections in Gondar region, Ethiopia (Publications)
between prorated 'worms' and the prevalence of A. lumbricoides [OR 0.63 (95% CI: 0.47-0.75)] and 'intestinal worms' [OR 0.55 (95% CI: 0.37-0.69)]. No sign or symptom was significantly associated with hookworm [...] ache', 'blood in stool', 'distended stomach'. and 'worms' using questionnaires and gave 24.0%, 64.9%, 18.6%. 37.0%, 38.1% 'yes' answers, respectively. At individual level reported 'worms' correlated with [...] value: 66.7%,...
Rapid urban malaria appraisal (RUMA) III: epidemiology of urban malaria in the municipality of Yopougon (Abidjan) (Publications)
42.0% (> five to 15 years-olds) and 26.8% (over 15 years-olds), while those in the control group were 13.0%. 26.7%, 21.8% and 14.6%, respectively. The fractions of malaria-attributable fever were 0.12 [...] 12, 0.22, 0.27 and 0.13 in the same age groups. Parasitaemia was homogenously detected in different areas of Yopougon. Among all children, 10.1% used a mosquito net (treated or not) the night before the [...] the survey and this was protective (OR = 0.52, 95% CI 0.29-0.97). Travel to rural...
Impact of a smoking ban in hospitality venues on second hand smoke exposure: a comparison of exposure assessment methods (Publications)
an average of 0.31 (0.17 to 0.45; n = 37) (p = 0.001). Personal badge measurements also significantly decreased from an average of 2.18 (1.31-3.05 n = 53) to 0.25 (0.13-0.36; n = 41) (p = 0.001).Spearman [...] Spearman rank correlations between badge exposure measures and salivary measures were small to moderate (0.3 at maximum). CONCLUSIONS: Nicotine levels significantly decreased in all types of hospitality venues
The relationship between water, sanitation and schistosomiasis: a systematic review and meta-analysis (Publications)
(OR) = 0.53, 95% confidence interval (CI): 0.47-0.61). Adequate sanitation was associated with lower odds of Schistosoma mansoni, (OR = 0.59, 95% CI: 0.47-0.73) and Schistosoma haematobium (OR = 0.69, 95% [...] 95% CI: 0.57-0.84). Included studies were mainly cross-sectional and quality was largely poor. CONCLUSIONS/SIGNIFICANCE: Our systematic review and meta-analysis suggests that increasing access to safe water
Allergic rhinitis and onset of bronchial hyperresponsiveness: a population-based study (Publications)
follow-up (OR [95% CI], 0.51 [0.33-0.78]). BHR "remission" was more frequent in patients with rhinitis treated by nasal steroids than in those not treated (OR [95% CI], 0.33 [0.14-0.75]). CONCLUSIONS: Allergic [...] and positive specific IgE (> or=0.35 IU/ml) to pollen, cat, mites, or Cladosporium. The cumulative incidence of BHR was 9.7% in subjects with allergic rhinitis and 7.0% in subjects with atopy but no rhinitis [...] ratios [OR] and their 95% confidence intervals [95% CI] for BHR onset,...
