suppression (adjusted risk difference −0.07 [95% CI −0.20 to 0.06]; p = 0.256). Arms were similar in linkage (adjusted risk difference 0.03 [−0.10 to 0.16]; p = 0.630), but engagement in care was non-s [...] non-significantly lower in the intervention arm (adjusted risk difference −0.12 [−0.23 to 0.003]; p = 0.058). Seven and 0 deaths occurred in the intervention and control arm, respectively. Of the intervention [...] health workers after initiation in the community. Main funding Swiss National...
suppression (adjusted risk difference −0.07 [95% CI −0.20 to 0.06]; p = 0.256). Arms were similar in linkage (adjusted risk difference 0.03 [−0.10 to 0.16]; p = 0.630), but engagement in care was non-s [...] non-significantly lower in the intervention arm (adjusted risk difference −0.12 [−0.23 to 0.003]; p = 0.058). Seven and 0 deaths occurred in the intervention and control arm, respectively. Of the intervention [...] health workers after initiation in the community. Main funding Swiss National...
Genetic variability and consequence of <em>Mycobacterium tuberculosis</em> lineage 3 in Kampala-Uganda (Publications)
384; CI 95% = 2.603-33.835), HIV (OR = 0.316; CI 95% = 0.114-0.876), lymphadenitis (OR = 0. 171; CI 95% = 0.034-0.856) and a BCG scar (OR = 0.295; CI 95% = 0.102-0.854). CONCLUSION: In Kampala, Uganda,
Randomized trial to improve children's body composition and micronutrient status among South African children (Publications)
months (Beta 0.16, 95% CI = 0.12, 0.31). The PA and MMNS arms both had positive indirect effects on this trajectory at 9 months (Beta 0.66, 95% CI = 0.44, 0.88 and Beta 0.32 95% CI = 0.1 0.5, respectively)
Prereferral rectal artesunate and referral completion among children with suspected severe malaria in the Democratic Republic of the Congo, Nigeria... (Publications)
referral than RAS non-users in the pre-roll-out phase (adjusted OR (aOR)=0.48, 95% CI 0.30 to 0.77 and aOR=0.72, 95% CI 0.58 to 0.88, respectively). Among children seeking care from a primary health centre [...] less likely to complete referral compared with RAS non-users in the post-roll-out phase (aOR=0.18, 95% CI 0.05 to 0.71). In Uganda, among children who completed referral, RAS users were significantly more
Evaluation of two communication tools, slideshow and theater, to improve participants' understanding of a clinical trial in the informed consent... (Publications)
86, p < 0.01). However, there was no evidence of an improvement compared to the IS only when participants attended a slideshow (0.09, 95% CI -0.53 to 0.35, p = 0.68) or a theater (0.28, 95% CI -0.27 to 0 [...] 0.82, p = 0.32). Three out of 10 key messages remained largely misunderstood, regardless of the mode of information group. CONCLUSIONS/SIGNIFICANCE: Our study confirmed that, in this setting, an ICF alone
Nevirapine, stavudine and lamivudine pharmacokinetics in African children on paediatric fixed-dose combination tablets (Publications)
Cmax and AUC12h of 6.0 (1.4, 16.9) mg/l, 10.0 (3.8, 22.5) mg/l and 94.4 (32.1, 232) mg/l per hour were higher than those reported in adults. Nevirapine C12h was subtherapeutic ( < 3.0 mg/l) in four children [...] children (6%). Mean stavudine and lamivudine C12h, Cmax, AUC12h ( < 0.015 mg/l, 0.45 mg/l, 1.05 mg/l per hour and 0.09 mg/l, 1.33 mg/l, 5.42 mg/l per hour) were comparable to adults. There was no evidence [...] a difference in nevirapine AUC12h across weight bands (P = 0.2), whereas the...
[90Yttrium-DOTA]-TOC response is associated with survival benefit in iodine-refractory thyroid cancer: long-term results of a phase 2 clinical trial (Publications)
time of diagnosis (hazard ratio [HR], 0.17; 95% confidence interval [CI], 0.03-0.92; P = .04) and from time of first [(90)Y-DOTA]-TOC therapy (HR, 0.20; 95% CI, 0.04-0.94; P = .04). The visual grade of s [...] scintigraphic tumor uptake was not associated with treatment response (odds ratio [OR], 0.98; 95% CI, 0.26-3.14; P = 1.00). CONCLUSIONS:: Response to [(90)Y-DOTA]-TOC in metastasized iodine-refractory thyroid [...] regression models. RESULTS:: A total of 24 patients were enrolled. A median...
Soil-transmitted helminth infection in South America: a systematic review and geostatistical meta-analysis (Publications)
substantially reduced since 2005 (odds ratio 0.47 [95% Bayesian credible interval 0.46-0.47] for A lumbricoides, 0.54 [0.54-0.55] for T trichiura, and 0.58 [0.58-0.59] for hookworm infection). INTERPRETATION:
Trends in weekly reported net use by children during and after rainy season in central Tanzania (Publications)
person-week decreased as the age of the child rose from 0 to six years old; at ages 0-23 months and 24-35 months use rates per person-week were 0.93 and 0.92 respectively during the study period, while for [...] use rates per person-week were 0.86 and 0.80. For children ages 5-6 person-week ratios dropped to 0.55. This represents an incidence rate ratio of 1.67 for children ages 0-23 months compared to children [...] children aged 5-6. Caretakers had use rates similar to those of children age 0-...
