Long term exposure to air pollution and kidney parenchyma cancer - effects of low-level air pollution: a study in Europe (ELAPSE) (Publications)
10 μg/m³ NO(2), 1.04 (95% CI: 0.88, 1.21) per 5 μg/m³ PM(2.5), 0.99 (95% CI: 0.89, 1.11) per 0.5 10(-5) m(-1) BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 μg/m³ O(3). We did not find associations between [...] 10(-5) m(-1) (0.7-2.1), and 87.0 μg/m(3) (70.3-97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 μg/m³ [...] parenchyma cancer according to the International Classification of Diseases...
Key factors predicting suspected severe malaria case management and health outcomes: an operational study in the Democratic Republic of the Congo (Publications)
(aOR = 0.63, 95% CI 0.44-0.92). After RAS rollout, 161 children died (case fatality ratio: 7.1%, 95% CI 6.1-8.2). RAS improved the health status of the children on Day 28 (aOR = 0.64, 95% CI 0.45-0.92) and [...] = 1.50, 95% CI 0.86-2.60). Full severe malaria treatment at the RHF including injectable anti-malarial and a course of ACT was highly protective against death (aOR = 0.26, 95% CI 0.09-0.79). CONCLUSIONS:
Marine natural products from the Turkish sponge <em>Agelas oroides</em> that inhibit the enoyl reductases from <em>Plasmodium falciparum</em>,<em>... (Publications)
component of the aq MeOH extract (IC(50) 5.0 microg/ml). Enzyme kinetic studies showed 4a to be an uncompetitive PfFabI inhibitor (K(i): 0.4+/-0.2 and 0.8+/-0.2 microM with respect to substrate and cofactor) [...] values 0.35 microg/ml). (E)-Oroidin isolated as free base (4a) was identified as the active component of the CHCl(3) extract. Compound 4a was a more potent PfFabI inhibitor (IC(50) 0.30 microg/ml=0.77 microM) [...] is (MtFabI, IC(50)s 9.4 and 8.2 microg/ml, respectively) and...
Determinants of virological failure and antiretroviral drug resistance in Mozambique (Publications)
19), P = 0.003] were associated with virological failure. Longer time on ART [OR = 1.55 per additional year (95% CI = 1.00-2.43), P = 0.052] and illiteracy [OR = 0.24 (95% CI = 0.07-0.89), P = 0.033] were [...] low-level viraemia. Younger age [OR = 0.97 per additional year (95% CI = 0.94-1.00), P = 0.039], ART initiation at WHO stage III/IV [OR = 2.10 (95% CI = 1.23-3.57), P = 0.003] and low ART adherence [OR = 2
Effect of vitamin A supplementation on morbidity due to <em>Plasmodium falciparum</em> in young children in Papua New Guinea: a randomised trial (Publications)
lower in the vitamin A group than in the placebo group (178 vs 249 episodes; relative risk 0.70 [95% CI 0.57-0.87], p=0.0013). At the end of the study P. falciparum geometric mean density was lower in the vitamin [...] difference was significant (p=0.093 and p=0.075). Children aged 12-36 months benefited most, having 35% fewer febrile episodes (89 vs 141; relative risk 0.65 [14-50], p=0.0023), 26% fewer enlarged spleens [...] spleens (46/79 [58%] vs 67/90 [74%], p=0.0045), and a 68% lower...
Diagnostic delay and associated factors among patients with pulmonary tuberculosis in Dar es Salaam, Tanzania (Publications)
19; P < 0.001), and presence of hemoptysis (aOR = 25.37, 95% CI: 11.15-57.74; P < 0.001) and negatively associated with use of medication prior to TB diagnosis (aOR = 0.31, 95% CI: 0.14-0.71; P = 0.01). Age [...] likely to visit a HCF (incremental increase of distance versus visit to any facility: OR = 0.51, 95% CI: 0.28-0.96; P = 0.037). CONCLUSIONS: TB diagnostic delay was common in Dar es Salaam, and was more likely
Potential associations between <em>Schistosoma mansoni</em> infection and physico-chemical characteristics and water-related human activities in Côte... (Publications)
confidence interval [CI] 21.5-34.3%) and 0.1% (95% CI 0.03-0.5%), respectively. Low prevalence of soil-transmitted helminths was observed with 2.4%, 0.4% and 0.2% for hookworm, Trichuris trichiura and [...] 25.0-45.3%), 34.3% (95% CI 24.0-46.2%) and 16.3% (95% CI 9.5-26.6%) for Biankouma, Ouaninou and Touba, respectively. Female and male participants were at a similar risk of infection (29.0% vs. 26.0%, odds [...] odds ratio [OR]: 1.18, 95% CI 0.92-1.50). Children aged 9-14 years showed a higher...
Use of a handheld ultrasonographic device to identify heart failure and pulmonary disease in rural Africa (Publications)
ranging from -0.008 to 0.76. Between clinicians and senior physicians, diagnosis agreements were 85% (κ, 0.69) for heart failure, 78% (κ, 0.57) for definite or probable tuberculosis, 50% (κ, 0.002) for viral [...] (71%-99%), with κ ranging from -0.003 to 0.83. Median (range) agreement of diagnoses between clinicians and expert sonographers was 90% (50%-99%), with κ ranging from -0.002 to 0.76. Between clinicians and [...] viral pneumonia, and 56% (κ, 0.06) for bacterial pneumonia. CONCLUSIONS...
Long term exposure to air pollution and kidney parenchyma cancer - effects of low-level air pollution: a study in Europe (ELAPSE) (Publications)
10 μg/m³ NO(2), 1.04 (95% CI: 0.88, 1.21) per 5 μg/m³ PM(2.5), 0.99 (95% CI: 0.89, 1.11) per 0.5 10(-5) m(-1) BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 μg/m³ O(3). We did not find associations between [...] 10(-5) m(-1) (0.7-2.1), and 87.0 μg/m(3) (70.3-97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 μg/m³ [...] parenchyma cancer according to the International Classification of Diseases...
Key factors predicting suspected severe malaria case management and health outcomes: an operational study in the Democratic Republic of the Congo (Publications)
(aOR = 0.63, 95% CI 0.44-0.92). After RAS rollout, 161 children died (case fatality ratio: 7.1%, 95% CI 6.1-8.2). RAS improved the health status of the children on Day 28 (aOR = 0.64, 95% CI 0.45-0.92) and [...] = 1.50, 95% CI 0.86-2.60). Full severe malaria treatment at the RHF including injectable anti-malarial and a course of ACT was highly protective against death (aOR = 0.26, 95% CI 0.09-0.79). CONCLUSIONS:
