Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell... (Publications)
compared to normal oral mucosa (P < 0.001). High LOX expression was correlated with clinical TNM stage (P = 0.020), lymph node metastases for the entire cohort (P < 0.001), as well as in the subgroup of [...] of small primary tumours (T1/T2, P < 0.001). Moreover, high LOX expression was correlated with poor overall survival (P = 0.004) and disease specific survival (P = 0.037). In a multivariate analysis, high
Evaluation of pet contact as a risk factor for carriage of multidrug-resistant staphylococci in nursing home residents (Publications)
(adjusted odds ratio [aOR], 0.6; 95% confidence interval [CI], 0.4-0.9). Active pet contact was associated with lower carriage of MDR staphylococci (aOR, 0.5; 95% CI, 0.4-0.8). Antibiotic treatment during
Evaluation of land use regression models for NO2 and particulate matter in 20 European study areas: the ESCAPE project (Publications)
For NO2, PM2.5 absorbance and PM10 Cu, the median LOOCV R2s were 0.83, 0.81 and 0.76 whereas the median HEV R2 were 0.52, 0.44 and 0.40. There was a positive association between the LOOCV R2 and HEV R2
Epidemiology of curable sexually transmitted infections among women at increased risk for HIV in northwestern Tanzania: inadequacy of syndromic... (Publications)
decreases over time for C. trachomatis and T. vaginalis (OR trend per month: 0.94 [95% CI 0.91, 0.97]; and 0.95 [0.93, 0.98], respectively; both p
Tuberculosis mortality and living conditions in Bern, Switzerland, 1856-1950 (Publications)
persons per room (r = 0.69, p = 0.026), the percentage of rooms without sunlight (r = 0.72, p = 0.020), and negatively with the number of windows per apartment (r = -0.79, p = 0.007). TB mortality decreased
Relative validation of a food frequency questionnaire to estimate food intake in an adult population (Publications)
two instruments ranged from 0.27 (carbohydrates) to 0.55 (protein), and at food group level from 0.09 (soup) to 0.92 (alcohol). Nine out of 25 food groups showed correlations > 0.5, indicating moderate validity [...] FFQ, especially vegetables (82.8%) and fruits (56.3%). Water, tea and coffee were underestimated (-14.0%). Conclusions: The FFQ showed moderate relative validity for protein and the food groups fruits, egg
Effects of liver-stage clearance by Primaquine on gametocyte carriage of <em>Plasmodium vivax</em> and <em>P. falciparum</em> (Publications)
infections compared to single-species infections for both species (ORPv = 0.39 [95% CI 0.25-0.62], ORPf = 0.33 [95% CI 0.18-0.60], p
Antiplasmodial imidazopyridazines: structure-activity relationship studies lead to the identification of analogues with improved solubility and hERG... (Publications)
identified new analogues with potent antiplasmodial activity (IC50 = 0.031 muM against the NF54 drug-sensitive strain, and IC50 = 0.0246 muM against the K1 multidrug resistant strain), hERG inhibition [...] inhibition profile (IC50 = 7.83-32.3 muM) with sub-micromolar antiplasmodial activity (NF54, IC50 = 0.151-0.922 muM) were identified. Similarly, the introduced molecular features also resulted in analogues [...] solubility (60-200 muM) while also displaying sub-micromolar antiplasmodial...
Measuring health facility readiness and its effects on severe malaria outcomes in Uganda (Publications)
alone for HCIIIs and HCIIs, respectively. Mortality rate was 64% (IRR = 0.36, 95% BCI: 0.14-0.61) and 68% (IRR = 0.32, 95% BCI: 0.12-0.54) lower in the medium and high compared to low readiness groups, r
Obstetric outcomes of Eritrean immigrants in Switzerland: a comparative study (Publications)
Results: Compared with Swiss, Eritrean women had a lower rate of primary C-section (Adj. OR 0.73, 95% CI [0.60, 0.89]) but a higher risk of initially planned vaginal deliveries ending in emergency C-section [...] CI [1.05, 1.63]). Eritrean women were less likely to receive epidural analgesia (Adj. OR 0.53, 95% CI [0.45, 0.62]) and more likely to not receive any analgesia (Adj. OR 1.73, 95% CI [1.52, 1.96]). Conclusion:
