Tuberculosis mortality and living conditions in Bern, Switzerland, 1856-1950 (Publications)
persons per room (r = 0.69, p = 0.026), the percentage of rooms without sunlight (r = 0.72, p = 0.020), and negatively with the number of windows per apartment (r = -0.79, p = 0.007). TB mortality decreased
Relative validation of a food frequency questionnaire to estimate food intake in an adult population (Publications)
two instruments ranged from 0.27 (carbohydrates) to 0.55 (protein), and at food group level from 0.09 (soup) to 0.92 (alcohol). Nine out of 25 food groups showed correlations > 0.5, indicating moderate validity [...] FFQ, especially vegetables (82.8%) and fruits (56.3%). Water, tea and coffee were underestimated (-14.0%). Conclusions: The FFQ showed moderate relative validity for protein and the food groups fruits, egg
Effects of liver-stage clearance by Primaquine on gametocyte carriage of <em>Plasmodium vivax</em> and <em>P. falciparum</em> (Publications)
infections compared to single-species infections for both species (ORPv = 0.39 [95% CI 0.25-0.62], ORPf = 0.33 [95% CI 0.18-0.60], p
Antiplasmodial imidazopyridazines: structure-activity relationship studies lead to the identification of analogues with improved solubility and hERG... (Publications)
identified new analogues with potent antiplasmodial activity (IC50 = 0.031 muM against the NF54 drug-sensitive strain, and IC50 = 0.0246 muM against the K1 multidrug resistant strain), hERG inhibition [...] inhibition profile (IC50 = 7.83-32.3 muM) with sub-micromolar antiplasmodial activity (NF54, IC50 = 0.151-0.922 muM) were identified. Similarly, the introduced molecular features also resulted in analogues [...] solubility (60-200 muM) while also displaying sub-micromolar antiplasmodial...
Measuring health facility readiness and its effects on severe malaria outcomes in Uganda (Publications)
alone for HCIIIs and HCIIs, respectively. Mortality rate was 64% (IRR = 0.36, 95% BCI: 0.14-0.61) and 68% (IRR = 0.32, 95% BCI: 0.12-0.54) lower in the medium and high compared to low readiness groups, r
Evaluating the use of educational videos to support the tuberculosis care cascade in remote Madagascar (Publications)
pre- and post-test scores, wherein scores increased by a median of 10.0% (interquartile range 0.0-20.0) after viewing the videos (P < 0.001). There was a significant difference between the number of correct [...] correct answers on the pre-test and the number of correct answers on the post-test (P < 0.001).CONCLUSION: Educational videos were found to significantly improve TB knowledge among a low-literacy, remote
Selektionierung von chloroquinresistenten <em>Plasmodium-falciparum</em>-Stämmen bei Touristen unter Chemoprophylaxe (Publications)
concentration. All 6 patients taking correct chloroquine prophylaxis (chloroquine plasma levels between 0.1-0.5 nmol/ml) harboured highly resistant P. falciparum strains (schizont maturation at 3.2 and 6.4 nmol/ml [...] nmol/ml blood in 3 patients each). In the 4 patients with inadequate prophylaxis (plasma levels between 0.02-0.1 nmol/ml) the degree of resistance was lower (at 1.6 and 6.4 nmol/ml blood in 2 patients each). [...] Chloroquine-sensitive strains were found only in patients with...
Premature atrial contractions in the general population: frequency and risk factors (Publications)
> /=50 years. The median (interquartile range) number of PACs per hour was 0.8 (0.4-1.8), 1.1 (0.5-2.4), 1.4 (0.7-4.6), 2.3 (0.8-6.9) and 2.6 (1.2-6.5) among participants aged 50-55, 55-60, 60-65, 65-70
Selektionierung von chloroquinresistenten <em>Plasmodium-falciparum</em>-Stämmen bei Touristen unter Chemoprophylaxe (Publications)
concentration. All 6 patients taking correct chloroquine prophylaxis (chloroquine plasma levels between 0.1-0.5 nmol/ml) harboured highly resistant P. falciparum strains (schizont maturation at 3.2 and 6.4 nmol/ml [...] nmol/ml blood in 3 patients each). In the 4 patients with inadequate prophylaxis (plasma levels between 0.02-0.1 nmol/ml) the degree of resistance was lower (at 1.6 and 6.4 nmol/ml blood in 2 patients each). [...] Chloroquine-sensitive strains were found only in patients with...
Premature atrial contractions in the general population: frequency and risk factors (Publications)
> /=50 years. The median (interquartile range) number of PACs per hour was 0.8 (0.4-1.8), 1.1 (0.5-2.4), 1.4 (0.7-4.6), 2.3 (0.8-6.9) and 2.6 (1.2-6.5) among participants aged 50-55, 55-60, 60-65, 65-70
