Asymptomatic only at first sight: malaria infection among schoolchildren in highland Rwanda (Publications)
was asymptomatic (fever 2.7%). Plasmodium infection was detected in 22.4% (Plasmodium falciparum, 18.8%); 41% of these were submicroscopic. Independent predictors of infection included low altitude, higher [...] Plasmodium infection was associated with anaemia (mean haemoglobin difference of -1.2 g/dL; 95% CI, -0.8 to -1.5 g/dL), fever, underweight, clinically assessed malnutrition and histories of fever, tiredness
Ten-year follow-up of cluster-based asthma phenotypes in adults: a pooled analysis of three cohorts (Publications)
simultaneously considered. Main Results: LTA identifies 7 asthma phenotypes (prevalence range: 8.4% to 20.8%), mainly characterized by the level of asthma symptoms (low, moderate, high), the allergic status
Long-term exposure to traffic-related PM10 and decreased heart rate variability: is the association restricted to subjects taking ACE inhibitors? (Publications)
(HF) power, of 4.5% (-8.2 to -0.5) in the standard deviation of all normal-to-normal RR intervals (SDNN), of 10.6% (-18.5 to -1.9) in total power (TP) and an increase of 9.2% (0.8 to 20.2) in the LF/HF
Seasonal pattern of <em>Mycobacterium ulcerans</em>, the causative agent of Buruli ulcer, in the environment in Ghana (Publications)
50/1166 (4.3 %). The DNA was detected mainly in snails (5/6, 83 %), moss (8/40, 20 %), soil (55/586, 9 %) and vegetation (55/675, 8 %). The proportion of MU positive samples recorded was higher during the
Childhood hospitalisation and related deaths in Hanoi, Vietnam: a tertiary hospital database analysis from 2007 to 2014 (Publications)
annual rate of emergency visits was 2.2 per 1000 children and the rate of hospital admissions was 13.8 per 1000 children. The annual rates for infants increased significantly by 3.9 per 1000 children during [...] of emergency visits, whereas respiratory diseases (37.7%) and bacterial and parasitic infections (19.8%) accounted for most hospital admissions. Patients with mental and behavioural disorders remained in
Mixed Th1 and Th2 <em>Mycobacterium tuberculosis</em>-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania (Publications)
and elevated serum levels of type I IFNs. Of note, the proportion of patients with Mtb-specific CD8 T cells was significantly reduced in Mtb/helminth co-infected patients from TZ. It is likely that the [...] patients from TZ. Taken together, these results indicate that the generation of Mtb-specific CD4 and CD8 T cell responses may be substantially influenced by environmental factors in vivo. These observations
Strengthening HIV therapy and care in rural Tanzania affects rates of viral suppression (Publications)
13/17 (76.5%) had HIV-1 plasma viral loads of > 1000 copies/mL. CD4 cell count 8-fold increased odds of developing HIV-DRM (aOR = 8.46, 95% CI = 2.48-28.93, P = 0.001). Conclusions: High levels of viral suppression
Evaluation of two DNA extraction methods on the detection of <em>Strongyloides stercoralis</em> infection (Publications)
3-42.6) and 78.0% (95% CI 66.8-86.1) for the Baermann, QIA and POL methods, respectively. The sensitivity calculated for each day of Baermann separately was 60% (48.4-70.8%) and 64% (52.2-74.2%) for day
Association between gastrointestinal tract infections and glycated hemoglobin in school children of poor neighborhoods in Port Elizabeth, South Africa (Publications)
intervention was also investigated. FINDINGS: A high prevalence of 71.8% of prediabetes was measured in this group of children, with only 27.8% having HbA1c in the normal range. Helicobacter pylori was the
Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing (Publications)
weight, clearance rates for amodiaquine and desethylamodiaquine reached 50% of adult maturation at 2.8 (95% CI: 1.5 - 3.7) and 3.9 (95% CI: 2.6 - 5.3) months after birth, assuming a baby born at term. B [...] manufacturer dosing recommendations resulted in low desethylamodiaquine exposure in patients weighing 8 kg, 15 - 17 kg, 33 - 35 kg, and in patients > 62 kg compared to a typical 50 kg patient. We propose
