Unit | Molecular Diagnostics

The unit develops new tools for diagnosing parasitic diseases and for genotyping parasite strains and species. New diagnostic tests are applied to population-wide studies in endemic areas. Successful research products are transferred to the field and used for molecular monitoring of disease interventions. They are also used for individual diagnosis in patients referred to Swiss TPH. The scientific tasks of the service side are shaped in close collaboration with the medical personnel from the Swiss TPH Medical Department.

Our Focus

The unit's projects focus on malaria, Leishmania and HIV. We aim to develop novel laboratory tests and strategies for analysing epidemiological data. A major aim is to support malaria eliminiation efforts in our partner countries and to provide the knowledge-base for planning and choosing effective control strategies.

Eldh M et al. Multiplicity of asymptomatic Plasmodium falciparum infections and risk of clinical malaria: a systematic review and pooled analysis of individual participant data. J Infect Dis. 2019(in press). DOI: 10.1093/infdis/jiz510

Felger I, Snounou G, Hastings I, Moehrle J.J, Beck H.P. PCR correction strategies for malaria drug trials: updates and clarifications. Lancet Infect Dis. 2019(in press). DOI: 10.1016/S1473-3099(19)30426-8

Grossenbacher B. Molecular approaches for tracking residual malaria P. falciparum transmission in a close-to-elimination setting in Zanzibar. Basel: Swiss Tropical and Public Health Institute, 2019. MSc

Gruenberg M et al. Molecular and immunofluorescence-based quantification of male and female gametocytes in low-density P. falciparum infections and their relevance for transmission. J Infect Dis. 2019(in press). DOI: 10.1093/infdis/jiz420

Hofmann N.E et al. Diagnostic performance of conventional and ultrasensitive Rapid Diagnostic Tests for malaria in febrile outpatients in Tanzania. J Infect Dis. 2019;219(9):1490-1498. DOI: 10.1093/infdis/jiy676