Project
Human tuberculosis (TB) remains a global health emergency, causing 10 million new cases and 1.5 million deaths every year. TB manifests as a spectrum, ranging from self-cured or asymptomatic infection to active pulmonary and extra-pulmonary disease. Until recently, the common view was that only…
Tuberculosis (TB) encompasses pulmonary and extra-pulmonary infections by the deadly obligate human pathogen Mycobacterium tuberculosis (MTB). Upon exposure to infectious aerosols, host immune responses build up multi-cellular structures called granulomas that aim to encapsulate the bacteria at the…
Taking advantage of a unique collection of human clinical specimens and our established in vitro granuloma model, we aim to gain important knowledge on some of the intrinsic differential immune traits that defines a protective response against MTB. We will demonstrate that in vitro granulomas…