MODCOVID - Using model-based evidence to optimise medical intervention profiles and disease management strategies for COVID-19 control

Background: Country governments have imposed strict spatial distancing and lockdown measures to reduce infection incidence and associated disease burden of coronavirus infectious disease (COVID- 19). As of April 7th, there is no proven medical or pharmaceutical tool to prevent or treat the disease....

Ongoing
01.06.2020 - 31.12.2022
Research project
Disease and Intervention Dynamics
Melissa Penny
PATH malaria vaccine modelling

The malaria vaccine RTS,S is currently in Phase 4 studies and undergoing pilot implementation in 3 countries in Africa.  Supporting ongoing policy decisions by Gavi and MPAC/SAGE on RTS,S, model based estimates are required to take into account possible scenarios with other malaria interventions...

Ongoing
04.12.2017 - 30.04.2020
Research project
Disease and Intervention Dynamics
Melissa Penny
MMC elimination costing

The project will generate evidence on the trade-offs between cost and effectiveness of malaria elimination interventions. This includes surveillance and a range of targeted and focal malaria elimination interventions when added incrementally to current levels of routine malaria control and case...

Ongoing
01.12.2017 - 31.10.2020
Research project
Disease and Intervention Dynamics
Melissa Penny
SNF_FP_modelling - Multi-scale mathematical modelling of parasite, drug and vaccine interactions: optimising public health and disease elimination strategies

 

Tremendous progress has been made over the last decades in controlling malaria. From 2000 to 2015 scale-up of control and curative interventions enabled a 60% reduction in malaria death rates and a 40% reduction in rate of clinical disease. Despite these gains, we face significant challenges if we...

Ongoing
01.07.2017 - 31.07.2021
Research project
Infectious Disease Modelling, Disease and Intervention Dynamics
Melissa Penny
Developing a modelling framework for malaria transmission prevention tools

Following years of investment in strategies to control malaria, elimination is now being considered. But optimal delivery strategies and profiles for new tools for elimination differ from those of disease control. The efficacy profiles of new drugs, vaccines and vector control, along with how to...

Ongoing
01.05.2017 - 31.03.2018
Research project
Infectious Disease Modelling, Disease and Intervention Dynamics
Melissa Penny
RGS Effective coverage - Impact of systems failures in malaria service delivery in Africa

Malaria treatment provides individual benefits by curing infection and preventing progression to severe disease. Treatment also provides community-level benefits by reducing the infectious reservoir. However, across endemic countries treatment does not always lead to a complete parasitological cure,...

Ongoing
01.01.2016 - 31.12.2018
Research project
Infectious Disease Modelling, Disease and Intervention Dynamics
Melissa Penny
RGS Model Drug Development - Modelling and simulation for drug development at Swiss TPH: clinical anthelminthic drug development and preclinical antimalarial development

This research project is aligned with priorities of the Swiss Tropical and Public Health Institute, namely integrating drug discovery and drug development with modeling. Aiming to strengthen capacity at the institute for model based research and development of existing and novel drugs we propose to...

Ongoing
01.01.2016 - 30.06.2017
Research project
Infectious Disease Modelling, Disease and Intervention Dynamics
Melissa Penny
PATH - PATH - MVI Malaria Vaccine Modeling: Service Agreement

Swiss TPH is carrying out simulations of the public health impact of the RTS,S malaria vaccine, with the support of PATH-MVI. The work involves simulation of the impact of adding vaccines in the context of improved control, considering various vaccine profiles and deployment strategies. The work...

Ongoing
01.11.2009 - 31.12.2017
Research project
PATH Malaria Vaccine Initiative (MVI)
Infectious Disease Modelling, Disease and Intervention Dynamics
Melissa Penny