Gordon C.A, Utzinger J, Muhi S, Becker S.L, Keiser J, Khieu V, Gray D.J. Strongyloidiasis. Nat Rev Dis Primers. 2024;10:6. DOI: 10.1038/s41572-023-00490-x

2024
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Qian M.B, Keiser J, Utzinger J, Zhou X.N. Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control. Clin Microbiol Rev. 2024(in press). DOI: 10.1128/cmr.00009-23

2024
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Shanley H.T, Taki A.C, Nguyen N, Wang T, Byrne J.J, Ang C.S, Leeming M.G, Nie S, Williamson N, Zheng Y, Young N.D, Korhonen P.K, Hofmann A, Chang B.C.H, Wells T.N.C, Häberli C, Keiser J, Jabbar A, Sleebs B.E, Gasser R.B. Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity. Int J Parasitol Drugs Drug Resist. 2024;24(in press):100522. DOI: 10.1016/j.ijpddr.2024.100522

2024
Journal Article
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Sprecher V.P, Hofmann D, Savathdy V, Xayavong P, Norkhankhame C, Huy R, Khieu V, Sayasone S, Hattendorf J, Keiser J. Efficacy and safety of moxidectin compared with ivermectin against Strongyloides stercoralis infection in adults in Laos and Cambodia: a randomised, double-blind, non-inferiority, phase 2b/3 trial. Lancet Infect Dis. 2024;24(2):196-205. DOI: 10.1016/s1473-3099(23)00507-8

2024
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Stettler M, Lotz C, Probst A, Marreros N, Lundström-Stadelmann B, Frey C.F, Keiser J, Hofer A, Hoby S. Safety and pharmacokinetics of praziquantel in european pond turtles (Emys orbicularis). J Zoo Wildl Med. 2024;54(4):728-737. DOI: 10.1638/2023-0031

2024
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Biendl S, Häberli C, Chen G, Wang W, Zhong L, Saunders J, Pham T, Wang X, Wu J, Charman S.A, Vennerstrom J.L, Keiser J. In vitro and in vivo antischistosomal activity profiling and pharmacokinetics of ozonide carboxylic acids. ACS Infect Dis. 2023;9(3):643-652. DOI: 10.1021/acsinfecdis.2c00581

2023
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Brooker S.J, Keiser J, Bundy D.A.P. Soil-transmitted helminths (geohelminths). In: Farrar J,Hotez P.J,Junghanss T,Kang G,Lalloo D,White N.J,Garcia P.J, eds. Manson's Tropical Diseases, 772-796. Amsterdam: Elsevier, 2023. DOI: 10.1016/B978-0-7020-7959-7.00060-9

2023
Book Section

Cappuccino C, Spoletti E, Renni F, Muntoni E, Keiser J, Voinovich D, Perissutti B, Lusi M. Co-crystalline solid solution affords a high-soluble and fast-absorbing form of praziquantel. Mol Pharm. 2023;20(4):2009-2016. DOI: 10.1021/acs.molpharmaceut.2c00984

2023
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Coffeng L.E, Vlaminck J, Cools P, Denwood M, Albonico M, Ame S.M, Ayana M, Dana D, Cringoli G, de Vlas S.J, Fenwick A, French M, Kazienga A, Keiser J, Knopp S, Leta G, Matoso L.F, Maurelli M.P, Montresor A, Mirams G, Mekonnen Z, Corrêa-Oliveira R, Pinto S.A, Rinaldi L, Sayasone S, Steinmann P, Thomas E, Vercruysse J, Levecke B. A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs-monitoring of therapeutic drug efficacy as a case study. PLoS Negl Trop Dis. 2023;17(5):e0011071. DOI: 10.1371/journal.pntd.0011071

2023
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Coulibaly J.T, Silue K.D, Armstrong M, Díaz de León Derby M, D'Ambrosio M.V, Fletcher D.A, Keiser J, Fisher K, Andrews J.R, Bogoch I.I. High sensitivity of mobile phone microscopy screening for Schistosoma haematobium in Azaguié, Côte d'Ivoire. Am J Trop Med Hyg. 2023;108(1):41-43. DOI: 10.4269/ajtmh.22-0527

2023
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D'Abbrunzo I, Bianco E, Gigli L, Demitri N, Birolo R, Chierotti M.R, Škorić I, Keiser J, Häberli C, Voinovich D, Hasa D, Perissutti B. Praziquantel meets Niclosamide: a dual-drug antiparasitic cocrystal. Int J Pharm. 2023;644:123315. DOI: 10.1016/j.ijpharm.2023.123315

2023
Journal Article
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Easland E, Biendl S, Keiser J. Development of a hookworm egg hatching assay to determine the ovicidal effects of anthelminthics. Parasit Vectors. 2023;16:157. DOI: 10.1186/s13071-023-05771-8

2023
Journal Article
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Friedrich L, Park S.K, Ballard P, Ho Baeurle T.H, Maillard D, Bödding M, Keiser J, Marchant J.S, Spangenberg T. Metabolism of (R)-praziquantel versus the activation of a Parasite Transient Receptor Potential Melastatin ion channel. ChemMedChem. 2023;18(18):e202300140. DOI: 10.1002/cmdc.202300140

2023
Journal Article
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Hürlimann E, Hofmann D, Keiser J. Ivermectin and moxidectin against soil-transmitted helminth infections. Trends Parasitol. 2023;39(4):272-284. DOI: 10.1016/j.pt.2023.01.009

2023
Journal Article
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Kasago F.M, Häberli C, Keiser J, Masamba W. Design, synthesis and evaluation of praziquantel analogues and new molecular hybrids as potential antimalarial and anti-schistosomal agents. Molecules. 2023;28(13):5184. DOI: 10.3390/molecules28135184

2023
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Keiser J. Present drugs and future perspectives in treating soil-transmitted helminthiasis. Front Trop Dis. 2023;4:1282725. DOI: 10.3389/fitd.2023.1282725

2023
Journal Article

Mäser P, Bernhard S, Brun R, Burri C, Gagneux S, Hetzel M.W, Kaiser M, Lengeler C, Pluschke G, Reus E, Rottmann M, Utzinger J, Warryn L, Wittlin S, Keiser J. Key contributions by the Swiss Tropical and Public Health Institute towards new and better drugs for tropical diseases. Chimia (Aarau). 2023;77(9):593-606. DOI: 10.2533/chimia.2023.593

2023
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Meier L, Antillón M, Burri C, Chitnis N, Endriss Y, Keiser J, Moore S, Müller P, Penny M, Voss T.S, Mäser P, Utzinger J. Repurposing know-how for drug development: case studies from the Swiss Tropical and Public Health Institute. Chimia (Aarau). 2023;77(9):582-592. DOI: 10.2533/chimia.2023.582

2023
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Mrimi E.C, Palmeirim M.S, Minja E.G, Long K.Z, Keiser J. Correlation of cytokines with parasitic infections, undernutrition and micronutrient deficiency among schoolchildren in rural Tanzania: a cross-sectional study. Nutrients. 2023;15(8):1916. DOI: 10.3390/nu15081916

2023
Journal Article
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Mrimi E.C, Welsche S, Ali S.M, Hattendorf J, Keiser J. Emodepside for Trichuris trichiura and hookworm infection. N Engl J Med. 2023;388(20):1863-1875. DOI: 10.1056/NEJMoa2212825

2023
Journal Article
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Muya K, Kalonji M, Ilunga N.W, Maseho M, Kitambala M, Kalonda M, Ndoumba K, Byanga K, Wright C.W, Häberli C, Keiser J, Simbi L. Evaluation of 43 species of Congolese medicinal plants used traditionally for the treatment of schistosomiasis leading to the isolation of an anti-schistosomal phaeophytin from Pseudolachnostylis maprouneifolia Pax. J Ethnopharmacol. 2023;315:116688. DOI: 10.1016/j.jep.2023.116688

2023
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Noce B, Di Bello E, Zwergel C, Fioravanti R, Valente S, Rotili D, Masotti A, Ansari M.S.Z, Trisciuoglio D, Chakrabarti A, Romier C, Robaa D, Sippl W, Jung M, Häberli C, Keiser J, Mai A. Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages. ChemMedChem. 2023;18(3):e202200510. DOI: 10.1002/cmdc.202200510

2023
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Radulov P.S, Yaremenko I.A, Keiser J, Terent'ev A.O. Bridged 1,2,4-trioxolanes: SnCl4-catalyzed synthesis and an in vitro study against S. mansoni. Molecules. 2023;28(13). DOI: 10.3390/molecules28134913

2023
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Schärer A, Biendl S, Keiser J. Trichuris muris egg-hatching assay for anthelminthic drug discovery and characterization. Int J Parasitol Drugs Drug Resist. 2023;23:63-70. DOI: 10.1016/j.ijpddr.2023.10.001

2023
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Specht S, Keiser J. Helminth infections: enabling the World Health Organization road map. Int J Parasitol. 2023;53(8):411-414. DOI: 10.1016/j.ijpara.2022.10.006

2023
Journal Article
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Sprecher V.P, Coulibaly J.T, Hürlimann E, Hattendorf J, Keiser J. Efficacy and safety of moxidectin-albendazole and ivermectin-albendazole combination therapy compared to albendazole monotherapy in adolescents and adults infected with Trichuris trichiura: a randomized controlled superiority trial. Clin Infect Dis. 2023;77(9):1294-1302. DOI: 10.1093/cid/ciad387

2023
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Welsche S, Mrimi E.C, Hattendorf J, Hürlimann E, Ali S.M, Keiser J. Efficacy and safety of moxidectin and albendazole compared with ivermectin and albendazole coadministration in adolescents infected with Trichuris trichiura in Tanzania: an open-label, non-inferiority, randomised, controlled, phase 2/3 trial. Lancet Infect Dis. 2023;23(3):331-340. DOI: 10.1016/S1473-3099(22)00589-8

2023
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Angeli A, Ferraroni M, Carta F, Häberli C, Keiser J, Costantino G, Supuran C.T. Development of praziquantel sulphonamide derivatives as antischistosomal drugs. J Enzyme Inhib Med Chem. 2022;37(1):1479-1494. DOI: 10.1080/14756366.2022.2078970

2022
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Biendl S, Häberli C, Keiser J. Discovery of novel antischistosomal scaffolds from the open access Pandemic Response Box. Expert Rev Anti Infect Ther. 2022;20(4):621-629. DOI: 10.1080/14787210.2022.1990042

2022
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Cantara A, Luo Y, Dobrovolna M, Bohalova N, Fojta M, Verga D, Guittat L, Cucchiarini A, Savrimoutou S, Häberli C, Guillon J, Keiser J, Brazda V, Mergny J.L. G-quadruplexes in helminth parasites. Nucleic Acids Res. 2022;50(5):2719-2735. DOI: 10.1093/nar/gkac129

2022
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Coulibaly J.T, Hürlimann E, Patel C, Silué D.K, Avenié D.J, Kouamé N.A, Silué U.M, Keiser J. Optimizing implementation of preventive chemotherapy against soil-transmitted helminthiasis and intestinal schistosomiasis using high-resolution data: field-based experiences from Côte d'Ivoire. Diseases. 2022;10(4):66. DOI: 10.3390/diseases10040066

2022
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Di Bello E, Noce B, Fioravanti R, Zwergel C, Valente S, Rotili D, Fianco G, Trisciuoglio D, Mourão M.M, Sales P. Jr, Lamotte S, Prina E, Späth G.F, Häberli C, Keiser J, Mai A. Effects of structurally different HDAC inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni. ACS Infect Dis. 2022;8(7):1356-1366. DOI: 10.1021/acsinfecdis.2c00232

2022
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Dube M, Llanes D, Saoud M, Rennert R, Imming P, Häberli C, Keiser J, Arnold N. Albatrellus confluens (Alb. & Schwein.) Kotl. & Pouz.: natural fungal compounds and synthetic derivatives with in vitro anthelmintic activities and antiproliferative effects against two human cancer cell lines. Molecules. 2022;27(9):2950. DOI: 10.3390/molecules27092950

2022
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Dube M, Raphane B, Sethebe B, Seputhe N, Tiroyakgosi T, Imming P, Häberli C, Keiser J, Arnold N, Andrae-Marobela K. Medicinal plant preparations administered by Botswana traditional health practitioners for treatment of worm infections show anthelmintic activities. Plants (Basel). 2022;11(21):2945. DOI: 10.3390/plants11212945

2022
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Falcoz C, Guzy S, Kovač J, Meister I, Coulibaly J, Sayasone S, Wesche D, Lin Y.W, Keiser J. R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini. J Pharmacokinet Pharmacodyn. 2022;49(3):293-310. DOI: 10.1007/s10928-021-09791-8

2022
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Falcoz C, Guzy S, Kovac J, Meister I, Coulibaly J, Sayasone S, Wesche D, Lin Y.W, Keiser J. Correction to: R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini. J Pharmacokinet Pharmacodyn. 2022;49(3):395. DOI: 10.1007/s10928-022-09807-x

2022
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Grolimund C.M, Bärenbold O, Utzinger J, Keiser J, Vounatsou P. Modeling the effect of different drugs and treatment regimen for hookworm on cure and egg reduction rates taking into account diagnostic error. PLoS Negl Trop Dis. 2022;16(10):e0010810. DOI: 10.1371/journal.pntd.0010810

2022
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Hamway Y, Zimmermann K, Blommers M.J.J, Sousa M, Häberli C, Kulkarni S, Skalicky S, Hackl M, Götte M, Keiser J, da Costa C.P, Spangenberg T, Azzaoui K. Modulation of host-parasite interactions with small molecules targeting Schistosoma mansoni microRNAs. ACS Infect Dis. 2022;8:2028−2034. DOI: 10.1021/acsinfecdis.2c00360

2022
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Harrington S, Knox J.J, Burns A.R, Choo K.L, Au A, Kitner M, Häberli C, Pyche J, D'Amata C, Kim Y.H, Volpatti J.R, Guiliani M, Snider J, Wong V, Palmeira B.M, Redman E.M, Vaidya A.S, Gilleard J.S, Stagljar I, Cutler S.R, Kulke D, Dowling J.J, Yip C.M, Keiser J, Zasada I, Lautens M, Roy P.J. Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release. Commun Biol. 2022;5:865. DOI: 10.1038/s42003-022-03819-6

2022
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Hassan M.M, Sedighi A, Olaoye O.O, Häberli C, Merz A, Ramos-Morales E, de Araujo E.D, Romier C, Jung M, Keiser J, Gunning P.T. Phenotypic screening of histone deacetylase (HDAC) inhibitors against Schistosoma mansoni. ChemMedChem. 2022:e202100622. DOI: 10.1002/cmdc.202100622

2022
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Herath H.M.P.D, Taki A.C, Rostami A, Jabbar A, Keiser J, Geary T.G, Gasser R.B. Whole-organism phenotypic screening methods used in early-phase anthelmintic drug discovery. Biotechnol Adv. 2022;57:107937. DOI: 10.1016/j.biotechadv.2022.107937

2022
Journal Article
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Hofmann D, Brussee J.M, Schulz J.D, Coulibaly J.T, Pfister M, Keiser J. Pharmacokinetic modelling and simulation to optimize albendazole dosing in hookworm- or Trichuris trichiura-infected infants to adults. J Antimicrob Chemother. 2022;77(4):1082-1093. DOI: 10.1093/jac/dkac020

2022
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Hofmann D, Smit C, Sayasone S, Pfister M, Keiser J. Optimizing moxidectin dosing for Strongyloides stercoralis infections: insights from pharmacometric modeling. Clin Transl Sci. 2022;15(3):700-708. DOI: 10.1111/cts.13189

2022
Journal Article
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Hürlimann E, Keller L, Patel C, Welsche S, Hattendorf J, Ali S.M, Ame S.M, Sayasone S, Coulibaly J.T, Keiser J. Efficacy and safety of co-administered ivermectin and albendazole in school-aged children and adults infected with Trichuris trichiura in Côte d'Ivoire, Laos, and Pemba Island, Tanzania: a double-blind, parallel-group, phase 3, randomised control. Lancet Infect Dis. 2022;22(1):123-135. DOI: 10.1016/S1473-3099(21)00421-7

2022
Journal Article
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Kersting L, Kuhn L, Anokhin M, Schuster F, Häberli C, Sambyal S, Kumar H.M.S, Keiser J, Alabugin I, Tsogoeva S.B. Visible-light-driven metal-free C-H functionalization: access to new bioactive tetrahydroisoquinoline-butenolide hybrids via domino amine oxidation/vinylogous Mannich reaction. ChemPhotoChem. 2022;6(8):e202200109. DOI: 10.1002/cptc.202200109

2022
Journal Article

Mrimi E.C, Palmeirim M.S, Minja E.G, Long K.Z, Keiser J. Malnutrition, anemia, micronutrient deficiency and parasitic infections among schoolchildren in rural Tanzania. PLoS Negl Trop Dis. 2022;16(3):e0010261. DOI: 10.1371/journal.pntd.0010261

2022
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Olliaro P.L, Vaillant M.T, Diawara A, Speich B, Albonico M, Utzinger J, Keiser J. Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment. PLoS Negl Trop Dis. 2022;16(8):e0010593. DOI: 10.1371/journal.pntd.0010593

2022
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Probst A, Biendl S, Keiser J. Improving translational power in antischistosomal drug discovery. Adv Parasitol. 2022;117:47-73. DOI: 10.1016/bs.apar.2022.05.002

2022
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Probst A, Hofmann D, Fedorova O.S, Mazeina S.V, Sokolova T.S, Golovach E, Keiser J. Pharmacokinetics of ascending doses of praziquantel in adults infected with Opisthorchis felineus in Western Siberia, Russian Federation. Antimicrob Agents Chemother. 2022;66(10):e00526-22. DOI: 10.1128/aac.00526-22

2022
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Qian M.B, Patel C, Palmeirim M.S, Wang X, Schindler C, Utzinger J, Zhou X.N, Keiser J. Efficacy of drugs against clonorchiasis and opisthorchiasis: a systematic review and network meta-analysis. Lancet Microbe. 2022;3(8):e616-e624. DOI: 10.1016/S2666-5247(22)00026-X

2022
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Ravaynia P.S, Biendl S, Grassi F, Keiser J, Hierlemann A, Modena M.M. Real-time and automated monitoring of antischistosomal drug activity profiles for screening of compound libraries. iScience. 2022;25(4):104087. DOI: 10.1016/j.isci.2022.104087

2022
Journal Article
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Ren R, Wang X, Leas D.A, Häberli C, Cal M, Dong Y, Kaiser M, Keiser J, Vennerstrom J.L. Antischistosomal tetrahydro-γ-carboline sulfonamides. Bioorg Med Chem Lett. 2022;59:128546. DOI: 10.1016/j.bmcl.2022.128546

2022
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Schneeberger P.H.H, Gueuning M, Welsche S, Hürlimann E, Dommann J, Häberli C, Frey J.E, Sayasone S, Keiser J. Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases. Nat Commun. 2022;13:1063. DOI: 10.1038/s41467-022-28658-1

2022
Journal Article
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Smit C, Hofmann D, Sayasone S, Keiser J, Pfister M. Characterization of the population pharmacokinetics of moxidectin in adults infected with Strongyloides stercoralis: support for a fixed-dose treatment regimen. Clin Pharmacokinet. 2022;61:123-132. DOI: 10.1007/s40262-021-01048-4

2022
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Taki A.C, Wang T, Nguyen N.N, Ang C.S, Leeming M.G, Nie S, Byrne J.J, Young N.D, Zheng Y, Ma G, Korhonen P.K, Koehler A.V, Williamson N.A, Hofmann A, Chang B.C.H, Häberli C, Keiser J, Jabbar A, Sleebs B.E, Gasser R.B. Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868. Front Pharmacol. 2022;13:1014804. DOI: 10.3389/fphar.2022.1014804

2022
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Taljaard L, Probst A, Tornow R, Keiser J, Haynes R.K, van der Kooy F. In vitro antischistosomal activity of Artemisia annua and Artemisia afra extracts. Phytomed Plus. 2022;2(3):100279. DOI: 10.1016/j.phyplu.2022.100279

2022
Journal Article

Valderas-García E, Häberli C, Álvarez-Bardón M, Escala N, Castilla-Gómez de Agüero V, de la Vega J, Del Olmo E, Balaña-Fouce R, Keiser J, Martínez-Valladares M. Benzimidazole and aminoalcohol derivatives show in vitro anthelmintic activity against Trichuris muris and Heligmosomoides polygyrus. Parasit Vectors. 2022;15:243. DOI: 10.1186/s13071-022-05347-y

2022
Journal Article
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Walker M, Freitas L.T, Halder J.B, Brack M, Keiser J, King C.H, Levecke B, Ai-Lian Lim Y, Pieri O, Sow D, Stothard J.R, Webster J.P, Zhou X.N, Terry R.F, Guérin P.J, Basáñez M.G. Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data. Wellcome Open Res. 2022;7:5. DOI: 10.12688/wellcomeopenres.17468.1

2022
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Bosch F, Palmeirim M.S, Ali S.M, Ame S.M, Hattendorf J, Keiser J. Diagnosis of soil-transmitted helminths using the Kato-Katz technique: what is the influence of stirring, storage time and storage temperature on stool sample egg counts?. PLoS Negl Trop Dis. 2021;15:e0009032. DOI: 10.1371/journal.pntd.0009032

2021
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Brussee J.M, Hiroshige N, Neodo A, Coulibaly J.T, Pfister M, Keiser J. Population pharmacokinetics and exposure-response analysis of tribendimidine to improve treatment for children with hookworm infection. Antimicrob Agents Chemother. 2021;65(2):e01778-20. DOI: 10.1128/AAC.01778-20

2021
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Brussee J.M, Neodo A, Schulz J.D, Coulibaly J.T, Pfister M, Keiser J. Pharmacometric analysis of tribendimidine mono- and combination therapies to achieve high cure rates in patients with hookworm infections. Antimicrob Agents Chemother. 2021;65(2):e00714-20. DOI: 10.1128/AAC.00714-20

2021
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Buchter V, Hofmann D, Häberli C, Keiser J. Characterization of moxidectin against Strongyloides ratti: in vitro and in vivo activity and pharmacokinetics in the rat model. ACS Infect Dis. 2021;7(5):1069-1076. DOI: 10.1021/acsinfecdis.0c00435

2021
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Buchter V, Schneeberger P.H.H, Keiser J. Validation of a human-serum-based in vitro growth method for drug screening on juvenile development stages of Schistosoma mansoni. PLoS Negl Trop Dis. 2021;15(3):e0009313. DOI: 10.1371/journal.pntd.0009313

2021
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Debbert S.L, Hintz M.J, Bell C.J, Earl K.R, Forsythe G.E, Häberli C, Keiser J. Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against Schistosoma mansoni. Antimicrob Agents Chemother. 2021;65(3):e01370-20. DOI: 10.1128/AAC.01370-20

2021
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Dube M, Saoud M, Rennert R, Fotso G.W, Andrae-Marobela K, Imming P, Häberli C, Keiser J, Arnold N. Anthelmintic activity and cytotoxic effects of compounds isolated from the fruits of Ozoroa insignis del. (Anacardiaceae). Biomolecules. 2021;11(12):1893. DOI: 10.3390/biom11121893

2021
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Hofmann D, Sayasone S, Keiser J. Development and validation of an LC-MS/MS method for the quantification of the anthelmintic drug moxidectin in a volumetric absorptive microsample, blood, and plasma: application to a pharmacokinetic study of adults infected with Strongyloides stercor. J Chromatogr B Analyt Technol Biomed Life Sci. 2021;1166:122556. DOI: 10.1016/j.jchromb.2021.122556

2021
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Hofmann D, Sayasone S, Sengngam K, Chongvilay B, Hattendorf J, Keiser J. Efficacy and safety of ascending doses of moxidectin against Strongyloides stercoralis infections in adults: a randomised, parallel-group, single-blinded, placebo-controlled, dose-ranging, phase 2a trial. Lancet Infect Dis. 2021;21(8):1151-1160. DOI: 10.1016/S1473-3099(20)30691-5

2021
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Jittamala P, Monteiro W, Smit M.R, Pedrique B, Specht S, Chaccour C.J, Dard C, Del Giudice P, Khieu V, Maruani A, Failoc-Rojas V.E, Saez-de-Ocariz M, Soriano-Arandes A, Piquero-Casals J, Faisant A, Brenier-Pinchart M.P, Wimmersberger D, Coulibaly J.T, Keiser J, Boralevi F, Sokana O, Marks M, Engelman D, Romani L, Steer A.C, von Seidlein L, White N.J, Harriss E, Stepniewska K, Humphreys G.S, Kennon K, Guerin P.J, Kobylinski K.C. A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: is it time to reconsider the current contraindication?. PLoS Negl Trop Dis. 2021;15(3):e0009144. DOI: 10.1371/journal.pntd.0009144

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Keiser J, Häberli C. Evaluation of commercially available anthelminthics in laboratory models of human intestinal nematode infections. ACS Infect Dis. 2021;7(5):1177-1185. DOI: 10.1021/acsinfecdis.0c00719

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Keiser J, Häberli C. Assessment of FDA-approved drugs against Strongyloides ratti in vitro and in vivo to identify potentially active drugs against strongyloidiasis. Parasit Vectors. 2021;14:615. DOI: 10.1186/s13071-021-05117-2

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Keller L, Hürlimann E, Patel C, Welsche S, Sayasone S, Ali S.M, Ame S.M, Coulibaly J.T, Keiser J. Insights gained from conductinga randomised controlled trial onIvermectin-albendazole against Trichuris trichiura in Côte d’Ivoire, Lao PDR and Pemba Island. Adv Parasitol. 2021;111:253-276. DOI: 10.1016/bs.apar.2020.11.001

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Keller L, Welsche S, Patel C, Sayasone S, Ali S.M, Ame S.M, Hattendorf J, Hürlimann E, Keiser J. Long-term outcomes of ivermectin-albendazole versus albendazole alone against soil-transmitted helminths: results from randomized controlled trials in Lao PDR and Pemba Island, Tanzania. PLoS Negl Trop Dis. 2021;15(6):e0009561. DOI: 10.1371/journal.pntd.0009561

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Krücken J, Holden-Dye L, Keiser J, Prichard R.K, Townson S, Makepeace B.L, Hubner M.P, Hahnel S.R, Scandale I, Harder A, Kulke D. Development of emodepside as a possible adulticidal treatment for human onchocerciasis-the fruit of a successful industrial-academic collaboration. PLoS Pathog. 2021;17(7):e1009682. DOI: 10.1371/journal.ppat.1009682

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Lombardo F.C, Ravaynia P.S, Modena M.M, Hierlemann A, Keiser J. Evaluation of human liver microtissues for drug screening on Schistosoma mansoni schistosomula. ACS Infect Dis. 2021;7(7):1894-1900. DOI: 10.1021/acsinfecdis.0c00614

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Nguyen W, Lee E.F, Evangelista M, Lee M, Harris T.J, Colman P.M, Smith N.A, Williams L.B, Jarman K.E, Lowes K.N, Häberli C, Keiser J, Smith B.J, Fairlie W.D, Sleebs B.E. Optimization of benzothiazole and thiazole hydrazones as inhibitors of schistosome bcl-2a. ACS Infect Dis. 2021;7(5):1143-1163. DOI: 10.1021/acsinfecdis.0c00700

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Palmeirim M.S, Mohammed U.A, Ross A, Ame S.M, Ali S.M, Keiser J. Evaluation of two communication tools, slideshow and theater, to improve participants' understanding of a clinical trial in the informed consent procedure on Pemba Island, Tanzania. PLoS Negl Trop Dis. 2021;15(5):e0009409. DOI: 10.1371/journal.pntd.0009409

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Palmeirim M.S, Mrimi E.C, Minja E.G, Samson A.J, Keiser J. A cross-sectional survey on parasitic infections in schoolchildren in a rural Tanzanian community. Acta Trop. 2021;213:105737. DOI: 10.1016/j.actatropica.2020.105737

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Palmeirim M.S, Specht S, Scandale I, Gander-Meisterernst I, Chabicovsky M, Keiser J. Preclinical and clinical characteristics of the trichuricidal drug oxantel pamoate and clinical development plans: a review. Drugs. 2021;81(8):907-921. DOI: 10.1007/s40265-021-01505-1

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Partridge F.A, Bataille C.J.R, Forman R, Marriott A.E, Forde-Thomas J, Häberli C, Dinsdale R.L, O'Sullivan J.D.B, Willis N.J, Wynne G.M, Whiteland H, Archer J, Steven A, Keiser J, Turner J.D, Hoffmann K.F, Taylor M.J, Else K.J, Russell A.J, Sattelle D.B. Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni. ACS Infect Dis. 2021;7(5):1260-1274. DOI: 10.1021/acsinfecdis.1c00025

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Patel C, Coulibaly J.T, Hofmann D, N'Gbesso Y, Hattendorf J, Keiser J. Efficacy and safety of albendazole in hookworm-infected preschool-aged children, school-aged children and adults in Côte d'Ivoire: a phase II randomized controlled dose-finding trial. Clin Infect Dis. 2021;73(2):e494-e502. DOI: 10.1093/cid/ciaa989

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