Dawidowski M, Kalel V.C, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko I.V, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz G.M. Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 protein-protein interaction with trypanocidal activity. J Med Chem. 2020;63(2):847-879. DOI: 10.1021/acs.jmedchem.9b01876

2020
Journal Article
PubMed (31860309)

Dickie E.A, Giordani F, Gould M.K, Mäser P, Burri C, Mottram J.C, Rao S.P.S, Barrett M.P. New drugs for human african trypanosomiasis: a twenty first century success story. Trop Med Infect Dis. 2020;5:29. DOI: 10.3390/tropicalmed5010029

2020
Journal Article
PubMed (32092897)
Link

Kaiser M, Mäser P. In vitro drug efficacy testing against Trypanosoma brucei. In: Michels P.A.M,Ginger M.L,Zilberstein D, eds. Trypanosomatids: methods and protocols. 2116, 781-789. New York: Springer, 2020. DOI: 10.1007/978-1-0716-0294-2_46

2020
Book Section
PubMed (32221955)

Rao S.P.S, Lakshminarayana S.B, Jiricek J, Kaiser M, Ritchie R, Myburgh E, Supek F, Tuntland T, Nagle A, Molteni V, Maser P, Mottram J.C, Barrett M.P, Diagana T.T. Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of african trypanosomiasis. Trop Med Infect Dis. 2020;5:28. DOI: 10.3390/tropicalmed5010028

2020
Journal Article
PubMed (32079320)
Link

Vahekeni N, Neto P.M, Kayimbo M.K, Mäser P, Theophile J, da Costa E, Falquet J, van Eeuwijk P. Use of herbal remedies in the management of sleeping sickness in four northern provinces of Angola. J Ethnopharmacol. 2020;256:112382. DOI: 10.1016/j.jep.2019.112382

2020
Journal Article
PubMed (31743767)

Wiedemar N, Hauser D.A, Mäser P. One hundred years of Suramin. Antimicrob Agents Chemother. 2020;64(3):e01168-19. DOI: 10.1128/AAC.01168-19

2020
Journal Article
PubMed (31844000)

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig J.A, Pisco J.P, Peet C, Dranow D.M, Robinson D.A, Jansen C, Norcross N.R, Vinayak S, Anderson M, Brooks C.F, Cooper C.A, Damerow S, Delves M, Dowers K, Duffy J, Edwards T.E, Hallyburton I, Horst B.G, Hulverson M.A, Ferguson L, Jiménez-Díaz M.B, Jumani R.S, Lorimer D.D, Love M.S, Maher S, Matthews H, McNamara C.W, Miller P, O'Neill S, Ojo K.K, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz L.M, Scullion P, Sharma A, Shepherd S.M, Shishikura Y, Simeons F.R.C, Stebbins E.E, Stojanovski L, Straschil U, Tamaki F.K, Tamjar J, Torrie L.S, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo F.J, Mäser P, Kyle D.E, Winzeler E.A, Myler P.J, Wyatt P.G, Floyd D, Matthews D, Sharma A, Striepen B, Huston C.D, Gray D.W, Fairlamb A.H, Pisliakov A.V, Walpole C, Read K.D, Van Voorhis W.C, Gilbert I.H. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc Natl Acad Sci USA. 2019;116(14):7015-7020. DOI: 10.1073/pnas.1814685116

2019
Journal Article
PubMed (30894487)
Link

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Antiprotozoal activities of tetrazole-quinolines with aminopiperidine linker. Med Chem. 2019;15(4):409-416. DOI: 10.2174/1573406414666181015115101

2019
Journal Article
PubMed (30324885)

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity. Bioorg Med Chem. 2019;27(10):2052-2065. DOI: 10.1016/j.bmc.2019.03.061

2019
Journal Article
PubMed (30962114)

Hoffelner M, Petritsch M, Ahmad S, Seebacher W, Dolensky J, Hochegger P, Kaiser M, Mäser P, Saf R, Weis R. New derivatives of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. Monatsh Chem. 2019;150(11):1959-1972. DOI: 10.1007/s00706-019-02509-0

2019
Journal Article

Jourdan J, Walz A, Matile H, Schmidt A, Wu J, Wang X, Dong Y, Vennerstrom J.L, Schmidt R.S, Wittlin S, Mäser P. Stochastic protein alkylation by antimalarial peroxides. ACS Infect Dis. 2019;5(12):2067-2075. DOI: 10.1021/acsinfecdis.9b00264

2019
Journal Article
PubMed (31626733)

Mäser P. Parasiten machen Geschichte. In: Bregy C,Buschle M,Settelen-Trees D, eds. Gespräche im Garten: Kultur - Natur - Gutes Leben: , 127-131. Basel: Christoph Merian Verlag, 2019

2019
Book Section

Mohsin N.U.A, Seebacher W, Hochegger P, Faist J, Saf R, Kaiser M, Mäser P, Weis R. Synthesis of new 1-benzyl tetrahydropyridin-4-ylidene piperidinium salts and their antiplasmodial and antitrypanosomal activities. Med Chem Res. 2019;28(5):742-753. DOI: 10.1007/s00044-019-02331-7

2019
Journal Article

Rao S.P.S, Barrett M.P, Dranoff G, Faraday C.J, Gimpelewicz C.R, Hailu A, Jones C.L, Kelly J.M, Lazdins-Helds J.K, Mäser P, Mengel J, Mottram J.C, Mowbray C.E, Sacks D.L, Scott P, Spath G.F, Tarleton R.L, Spector J.M, Diagana T.T. Drug discovery for kinetoplastid diseases: future directions. ACS Infect Dis. 2019;5(2):152-157. DOI: 10.1021/acsinfecdis.8b00298

2019
Journal Article
PubMed (30543391)

Saccoliti F, Madia V.N, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet Alvarez C.M, Jennings G.K, Podust L.M, Pepe G, Cirilli R, Faggi C, Di Marco A, Battista M.R, Summa V, Costi R, Di Santo R. Design, synthesis, and biological evaluation of new 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives as antiprotozoal agents. J Med Chem. 2019;62(3):1330-1347. DOI: 10.1021/acs.jmedchem.8b01464

2019
Journal Article
PubMed (30615444)

Walz A, Leroy D, Andenmatten N, Mäser P, Wittlin S. Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay. Malar J. 2019;18:427. DOI: 10.1186/s12936-019-3056-8

2019
Journal Article
PubMed (31849323)
Link

Wiedemar N, Zwyer M, Zoltner M, Cal M, Field M.C, Mäser P. Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei. FASEB Bioadv. 2019;1(10):595-608. DOI: 10.1096/fba.2019-00033

2019
Journal Article
PubMed (32123811)
Link

Grogg M, Hilvert D, Ebert M.O, Beck A.K, Seebach D, Kurth F, Dittrich P.S, Sparr C, Wittlin S, Rottmann M, Mäser P. Cell penetration, herbicidal activity, and in-vivo-toxicity of oligo-arginine derivatives and of novel guanidinium-rich compounds derived from the biopolymer cyanophycin. Helvetica Chimica Acta. 2018;101(10):e1800112. DOI: 10.1002/hlca.201800112

2018
Journal Article
PubMed (30905972)

Gysin M, Braissant O, Gillingwater K, Brun R, Mäser P, Wenzler T. Isothermal microcalorimetry – a quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time. Int J Parasitol Drugs Drug Resist. 2018;8(2):159-164. DOI: 10.1016/j.ijpddr.2018.03.003

2018
Journal Article
PubMed (29587237)
Link

Kalel V.C, Mäser P, Sattler M, Erdmann R, Popowicz G.M. Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development. Curr Opin Microbiol. 2018;46:116-122. DOI: 10.1016/j.mib.2018.11.003

2018
Journal Article
PubMed (30481613)

Mäser P. Host-Microbe Interactions: Parasitology Vol 46. Curr Opin Microbiol. 2018;46:vi-viii. DOI: 10.1016/j.mib.2018.11.008

2018
Journal Item
PubMed (30553295)

Mohsin N.U.A, Seebacher W, Faist J, Hochegger P, Kaiser M, Mäser P, Belaj F, Saf R, Kretschmer N, Alajlani M, Turek I, Brantner A, Bauer R, Bucar F, Weis R. Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. Eur J Med Chem. 2018;143:97-106. DOI: 10.1016/j.ejmech.2017.11.025

2018
Journal Article
PubMed (29172086)

Mohsin N.U.A, Seebacher W, Faist J, Hochegger P, Kaiser M, Mäser P, Saf R, Weis R. The antiplasmodial and antitrypanosomal activities of novel piperazine derivatives of 3-azabicyclo[3.2.2]nonanes. Monatsh Chem. 2018;149(1):99-109. DOI: 10.1007/s00706-017-2109-3

2018
Journal Article

Mohsin N.U.A, Seebacher W, Faist J, Kretschmer N, Bauer R, Saf R, Kaiser M, Mäser P, Weis R. Modifications on tetrahydropyridin-4-ylidene ammonium salts and their antiprotozoal activities. Monatsh Chem. 2018;149(4):801-812. DOI: 10.1007/s00706-017-2111-9

2018
Journal Article

Oufir M, Gillingwater K, Hamburger M, Roditi I, Brun R, Mäser P, Wenzler T. Pharmacokinetic profiles reconcile in vitro and in vivo activities of novel trypanocidal compounds. Matters. 2018;Aug 14th:07000009. DOI: 10.19185/matters.201807000009

2018
Journal Article
Link

Saccoliti F, Madia V.N, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P. Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents. Eur J Med Chem. 2018;156:53-60. DOI: 10.1016/j.ejmech.2018.06.063

2018
Journal Article
PubMed (30006174)

Schmidt R.S, Macedo J.P, Steinmann M.E, Salgado A.G, Butikofer P, Sigel E, Rentsch D, Mäser P. Transporters of Trypanosoma brucei: phylogeny, physiology, pharmacology. FEBS J. 2018;285(6):1012-1023. DOI: 10.1111/febs.14302

2018
Journal Article
PubMed (29063677)

Subramaniam S, Schmid C.D, Guan X.L, Mäser P. Using yeast synthetic lethality to inform drug combination for malaria. Antimicrob Agents Chemother. 2018;62(4):e01533-17. DOI: 10.1128/AAC.01533-17

2018
Journal Article
PubMed (29358287)
Link

Wiedemar N, Graf F.E, Zwyer M, Ndomba E, Kunz Renggli C, Cal M, Schmidt R.S, Wenzler T, Mäser P. Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei. Mol Microbiol. 2018;107(1):57-67. DOI: 10.1111/mmi.13854

2018
Journal Article
PubMed (28963732)
Link

Baumgärtner F, Jourdan J, Scheurer C, Blasco B, Campo B, Mäser P, Wittlin S. In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate. Malar J. 2017;16:45. DOI: 10.1186/s12936-017-1696-0

2017
Journal Article
PubMed (28122617)
Link

Dawidowski M, Emmanouilidis L, Kalel V.C, Tripsianes K, Schorpp K, Hadian K, Kaiser M, Mäser P, Kolonko M, Tanghe S, Rodriguez A, Schliebs W, Erdmann R, Sattler M, Popowicz G.M. Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites. Science. 2017;355(6332):1416-1420. DOI: 10.1126/science.aal1807

2017
Journal Article
PubMed (28360328)

Faist J, Hinteregger C, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. New derivatives of 7-chloroquinolin-4-amine with antiprotozoal activity. Bioorg Med Chem. 2017;25(3):941-948. DOI: 10.1016/j.bmc.2016.12.006

2017
Journal Article
PubMed (28031151)

Guan X.L, Mäser P. Comparative sphingolipidomics of disease-causing trypanosomatids reveal unique lifecycle- and taxonomy-specific lipid chemistries. Sci Rep. 2017;7:13617. DOI: 10.1038/s41598-017-13931-x

2017
Journal Article
PubMed (29051559)
Link

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. New derivatives of quinoline-4-carboxylic acid with antiplasmodial activity. Bioorg Med Chem. 2017;25(7):2251-2259. DOI: 10.1016/j.bmc.2017.02.043

2017
Journal Article
PubMed (28279559)

Jeacock L, Baker N, Wiedemar N, Mäser P, Horn D. Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity. PLoS Pathog. 2017;13(3):e1006307. DOI: 10.1371/journal.ppat.1006307

2017
Journal Article
PubMed (28358927)
Link

Mäser P. Cherchez l'electron. Mol Microbiol. 2017;106(2):183-185. DOI: 10.1111/mmi.13773

2017
Journal Item
PubMed (28833608)

Mathieu C, Macedo J.P, Hürlimann D, Wirdnam C, Haindrich A.C, Suter Grotemeyer M, Gonzalez-Salgado A, Schmidt R.S, Inbar E, Mäser P, Butikofer P, Zilberstein D, Rentsch D. Arginine and lysine transporters are essential for Trypanosoma brucei. PLoS One. 2017;12(1):e0168775. DOI: 10.1371/journal.pone.0168775

2017
Journal Article
PubMed (28045943)
Link

Seebacher W, Belaj F, Faist J, Saf R, Bucar F, Turek I, Brantner A, Alajlani M, Kaiser M, Mäser P, Weis R. Synthesis of new pyrido-benzodiazepine salts and their antimicrobial activities. Monatsh Chem. 2017;148(2):263-274. DOI: 10.1007/s00706-016-1864-x

2017
Journal Article

Steinmann M.E, Schmidt R.S, Bütikofer P, Mäser P, Sigel E. TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes. Sci Rep. 2017;7(1):656. DOI: 10.1038/s41598-017-00752-1

2017
Journal Article
PubMed (28386071)
Link

Steinmann M.E, Schmidt R.S, Macedo J.P, Kunz Renggli C, Bütikofer P, Rentsch D, Mäser P, Sigel E. Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei. PLoS One. 2017;12(12):e0188219. DOI: 10.1371/journal.pone.0188219

2017
Journal Article
PubMed (29244877)
Link

Graf F.E, Ludin P, Arquint C, Schmidt R.S, Schaub N, Kunz-Renggli C, Krezdorn J, Baker N, Horn D, Balmer O, Caccone A, de Koning H.P, Mäser P, Munday J.C. Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cell Mol Life Sci. 2016;37(17):3387. DOI: 10.1007/s00018-016-2173-6

2016
Journal Article
PubMed (26973180)

Jourdan J, Matile H, Reift E, Biehlmaier O, Dong Y, Wang X, Mäser P, Vennerstrom J.L, Wittlin S. Monoclonal antibodies that recognize the alkylation signature of antimalarial ozonides OZ277 (Arterolane) and OZ439 (Artefenomel). ACS Infect Dis. 2016;2:54-61. DOI: 10.1021/acsinfecdis.5b00090

2016
Journal Article
PubMed (26819968)

Mäser P, Brun R. From molecule to drug. In: Walochnik J,Duchêne M, eds. Molecular parasitology: protozoan parasites and their molecules, 491-507. Wien: Springer, 2016. DOI: 10.1007/978-3-7091-1416-2_15

2016
Book Section

Wang T, Mäser P, Picard D. Inhibition of Plasmodium falciparum Hsp90 contributes to the antimalarial activities of aminoalcohol-carbazoles. J Med Chem. 2016;59(13):6344-6352. DOI: 10.1021/acs.jmedchem.6b00591

2016
Journal Article
PubMed (27312008)

Wenzler T, Schumann Burkard G, Schmidt R.S, Mäser P, Bergner A, Roditi I, Brun R. A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes. Sci Rep. 2016;6:22451. DOI: 10.1038/srep22451

2016
Journal Article
PubMed (26931380)
Link

Beer D, Barret M, Begolo D, Clayton C, Jiricek J, Kaiser M, Koh H, Kounde C, Lakshminarayana S, Manoharan V, Mottram J, Myburgh E, Ng P, Rao S, Schirle M, Tania S, Thomas J, Vachaspati P, Vincent I, Wipfeli P, Wong J, Mäser P, Diagana T. Cell-based drug discovery model at the Novartis Institute for Tropical Diseases using Human African Trypanosomiasis as an example. Trop Med Int Health, 2015;20(Suppl. 1):125. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

2015
Conference Paper

Cal M, Ioset J.R, Fügi M, Mäser P, Kaiser M. An in vitro assay to assess antichagasic candidates for sterile cure. Trop Med Int Health, 2015;20(Suppl. 1):335. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

2015
Conference Paper

de Macedo J.P, Schumann Burkard G, Niemann M, Barrett M.P, Vial H, Mäser P, Roditi I, Schneider A, Bütikofer P. An atypical mitochondrial carrier that mediates drug action in Trypanosoma brucei. PLoS Pathog. 2015;11(5):e1004875. DOI: 10.1371/journal.ppat.1004875

2015
Journal Article
PubMed (25946070)
Link

Fesser A.F, Schmidt R.S, Mäser P, Cal M, Kaiser M. Stage-specific reporter gene expression in Trypanosoma cruzi. Trop Med Int Health, 2015;20(Suppl. 1):339. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

2015
Conference Paper

Fügi M.A, Kaiser M, Tanner M, Schneiter R, Mäser P, Guan X.L. Match-making for pasaconazole through systems thinking. Trends Parasitol. 2015;31(2):46-51. DOI: 10.1016/j.pt.2014.11.004

2015
Journal Article
PubMed (25486978)

Graf F.E, Baker N, Munday J.C, de Koning H.P, Horn D, Mäser P. Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. Int J Parasitol Drugs Drug Resist. 2015;5(2):65-68. DOI: 10.1016/j.ijpddr.2015.04.002

2015
Journal Article
PubMed (26042196)
Link

Jourdan J, Matile H, Vennerstrom J.L, Mäser P, Wittlin S. Mode of action of antimalarial peroxides. Trop Med Int Health, 2015;20(Suppl. 1):183. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

2015
Conference Paper

Kaiser M, Mäser P, Tadoori L.P, Ioset J.R, Brun R. Antiprotozoal activity profiling of approved drugs: a starting point toward drug repositioning. PLoS One. 2015;10(8):e0135556. DOI: 10.1371/journal.pone.0135556

2015
Journal Article
PubMed (26270335)
Link

Shameer S, Logan-Klumpler F.J, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach A.M, Bannerman-Chukualim B, Creek D.J, Crouch K, de Koning H.P, Denise H, Ebikeme C, Fairlamb A.H, Ferguson M.A, Ginger M.L, Hertz-Fowler C, Kerkhoven E.J, Mäser P, Michels P.A, Nayak A, Nes D.W, Nolan D.P, Olsen C, Silva-Franco F, Smith T.K, Taylor M.C, Tielens A.G, Urbaniak M.D, van Hellemond J.J, Vincent I.M, Wilkinson S.R, Wyllie S, Opperdoes F.R, Barrett M.P, Jourdan F. TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Res. 2015;43(D1):D637-D644. DOI: 10.1093/nar/gku944

2015
Journal Article
PubMed (25300491)

Steinmann M.E, González-Salgado A, Bütikofer P, Mäser P, Sigel E. A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes. FASEB J. 2015;29(8):3228-3237. DOI: 10.1096/fj.15-271353

2015
Journal Article
PubMed (25868728)

Wenzler T, Burkard G.S, Mäser P, Roditi I, Brun R. Drug-induced differentiation leads to lysis of African trypanosomes. Trop Med Int Health, 2015;20(Suppl. 1):166. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

2015
Conference Paper

Witschel M.C, Rottmann M, Schwab A, Leartsakulpanich U, Chitnumsub P, Seet M, Tonazzi S, Schwertz G, Stelzer F, Mietzner T, McNamara C, Thater F, Freymond C, Jaruwat A, Pinthong C, Riangrungroj P, Oufir M, Hamburger M, Mäser P, Sanz-Alonso L.M, Charman S, Wittlin S, Yuthavong Y, Chaiyen P, Diederich F. Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities. J Med Chem. 2015;58(7):3117-3130. DOI: 10.1021/jm501987h

2015
Journal Article
PubMed (25785478)

Fügi M.A, Gunasekera K, Ochsenreiter T, Guan X, Wenk M.R, Mäser P. Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack. J Lipid Res. 2014;55(5):929-938. DOI: 10.1194/jlr.M048017

2014
Journal Article
PubMed (24627128)

Lüscher A, Lamprea-Burgunder E, Graf F.E, de Koning H.P, Mäser P. Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity. Int J Parasitol Drugs Drug Resist. 2014;4(1):55-63. DOI: 10.1016/j.ijpddr.2013.12.001

2014
Journal Article
PubMed (24596669)
Link

Mathieu C, Salgado A.G, Wirdnam C, Meier S, Grotemeyer M.S, Inbar E, Mäser P, Zilberstein D, Sigel E, Bütikofer P, Rentsch D. Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids. Biochem J. 2014;463(1):9-18. DOI: 10.1042/BJ20140719

2014
Journal Article
PubMed (24988048)

Munday J.C, Eze A.A, Baker N, Glover L, Clucas C, Aguinaga Andres D, Natto M.J, Teka I.A, McDonald J, Lee R.S, Graf F.E, Ludin P, Burchmore R.J, Turner C.M, Tait A, Macleod A, Mäser P, Barrett M.P, Horn D, de Koning H.P. Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. J Antimicrob Chemother. 2014;69(3):651-663. DOI: 10.1093/jac/dkt442

2014
Journal Article
PubMed (24235095)

Sistrom M, Evans B, Bjornson R, Gibson W, Balmer O, Mäser P, Aksoy S, Caccone A. Comparative genomics reveals multiple genetic backgrounds of human pathogenicity in the Trypanosoma brucei complex. Genome Biol Evol. 2014;6(10):2811-2819. DOI: 10.1093/gbe/evu222

2014
Journal Article
PubMed (25287146)
Link

Wang T, Bisson W.H, Mäser P, Scapozza L, Picard D. Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective Inhibitors. J Med Chem. 2014;57(6):2524-2535. DOI: 10.1021/jm401801t

2014
Journal Article
PubMed (24580531)

Ali J.A.M, Creek D.J, Burgess K, Allison H.C, Field M.C, Mäser P, de Koning H.P. Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines. Mol Pharmacol. 2013;83(2):439-453. DOI: 10.1124/mol.112.082321

2013
Journal Article
PubMed (23188714)

Baker N, de Koning H.P, Mäser P, Horn D. Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. Trends Parasitol. 2013;29(3):110-118. DOI: 10.1016/j.pt.2012.12.005

2013
Journal Article
PubMed (23375541)

Graf F, Ludin P, Kunz-Renggli C, de Koning H.P, Mäser P. Comparative genomics of drug resistance in African trypanosomes. Virulence, 2013;4(4):337-338

2013
Conference Paper

Graf F.E, Ludin P, Wenzler T, Kaiser M, Brun R, Pyana P.P, Buscher P, de Koning H.P, Horn D, Mäser P. Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. PLoS Negl Trop Dis. 2013;7(10):e2475. DOI: 10.1371/journal.pntd.0002475

2013
Journal Article
PubMed (24130910)
Link

Greganova E, Steinmann M, Mäser P, Fankhauser N. In silico ionomics segregates parasitic from free-living eukaryotes. Genome Biol Evol. 2013;5(10):1902-1909. DOI: 10.1093/gbe/evt134

2013
Journal Article
PubMed (24048281)
Link

Macêdo J.P, Schmidt R.S, Mäser P, Rentsch D, Vial H.J, Sigel E, Butikofer P. Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms. Mol Biochem Parasitol. 2013;190(1):16-22. DOI: 10.1016/j.molbiopara.2013.05.007

2013
Journal Article
PubMed (23747277)

Nickel B, Ahmarani F, Pittet A, List C, Mäser P, Marti H. Evaluation of synthetic peptides from the K39-sequence for diagnostics of visceral leishmaniasis. Trop Med Int Health, 2013;18(Suppl. 1):138

2013
Conference Paper

Godel C, Kumar S, Koutsovoulos G, Ludin P, Nilsson D, Comandatore F, Wrobel N, Thompson M, Schmid C.D, Goto S, Bringaud F, Wolstenholme A, Bandi C, Epe C, Kaminsky R, Blaxter M, Mäser P. The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets. FASEB J. 2012;26(11):4650-4661. DOI: 10.1096/fj.12-205096

2012
Journal Article
PubMed (22889830)

Gonzalez-Salgado A, Steinmann M.E, Greganova E, Rauch M, Mäser P, Sigel E, Bütikofer P. myo-inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei. J Biol Chem. 2012;287(16):13313-13323. DOI: 10.1074/jbc.M112.344812

2012
Journal Article
PubMed (22351763)

Ludin P, Woodcroft B, Ralph S.A, Mäser P. In silicio prediction of antimalarial drug target candidates. Int J Parasitol Drugs Drug Resist. 2012;2:191-199. DOI: 10.1016/j.ijpddr.2012.07.002

2012
Journal Article
Link

Mäser P, Wittlin S, Rottmann M, Wenzler T, Kaiser M, Brun R. Antiparasitic agents: new drugs on the horizon. Curr Opin Pharmacol. 2012;12(5):562-566. DOI: 10.1016/j.coph.2012.05.001

2012
Journal Article
PubMed (22652215)

Oehring S.C, Woodcroft B.J, Moes S, Wetzel J, Dietz O, Pulfer A, Dekiwadia C, Mäser P, Flück C, Witmer K, Brancucci N.M, Niederwieser I, Jenoe P, Ralph S.A, Voss T.S. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Genome Biol. 2012;13(11):R108. DOI: 10.1186/gb-2012-13-11-r108

2012
Journal Article
PubMed (23181666)
Link

Lamprea-Burgunder E, Ludin P, Mäser P. Species-specific typing of DNA based on palindrome frequency patterns. DNA Res. 2011;18(2):117-124. DOI: 10.1093/dnares/dsr004

2011
Journal Article
PubMed (21429991)

Ludin P, Nilsson D, Mäser P. Genome-wide identification of molecular mimicry candidates in parasites. PLoS One. 2011;6(3):e17546. DOI: 10.1371/journal.pone.0017546

2011
Journal Article
PubMed (21408160)
Link

Teka I.A, Kazibwe A.J.N, El-Sabbagh N, Al-Salabi M.I, Ward C.P, Eze A.A, Munday J.C, Mäser P, Matovu E, Barrett M.P, de Koning H.P. The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Mol Pharmacol. 2011;80(1):110-116. DOI: 10.1124/mol.111.071555

2011
Journal Article
PubMed (21436312)

Mosimann M, Goshima S, Wenzler T, Luscher A, Uozumi N, Mäser P. A Trk/HKT-type K+ transporter from Trypanosoma brucei. Eukaryot Cell. 2010;9(4):539-546. DOI: 10.1128/EC.00314-09

2010
Journal Article
PubMed (20190075)

Nerima B, Mäser P. Identification of potential drug targets in protozoan parasites using comparative genomics. Am J Trop Med Hyg, 2010;83(5 Suppl. 1):205-205

2010
Conference Paper