Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine (Publications)
Human African trypanosomiasis is a neglected tropical disease with complex clinical presentation, diagnosis, and difficult treatment. The available drugs for the treatment of trypanosomiasis are old,
The acceptability of intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in... (Publications)
BACKGROUND: Intermittent preventive treatment of malaria in infants (IPTi) reduces the incidence of clinical malaria. However, before making decisions about implementation, it is essential to ensure t
<em>Plasmodium falciparum</em> msp1, msp2 and glurp allele frequency and diversity in Sub-Saharan Africa (Publications)
BACKGROUND: The efficacy of anti-malarial drugs is assessed over a period of 28-63 days (depending on the drugs' residence time) following initiation of treatment in order to capture late failures. Ho
Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data (Publications)
People living in endemic areas often habour several malaria infections at once. High-resolution genotyping can distinguish between infections by detecting the presence of different alleles at a polymo
MER41 repeat sequences contain inducible STAT1 binding sites (Publications)
Chromatin immunoprecipitation combined with massively parallel sequencing methods (ChIP-seq) is becoming the standard approach to study interactions of transcription factors (TF) with genomic sequence
Spatially-explicit risk profiling of<em> Plasmodium falciparum</em> infections at a small scale: a geostatistical modelling approach (Publications)
BACKGROUND: There is a renewed political will and financial support to eradicate malaria. Spatially-explicit risk profiling will play an important role in this endeavour. Patterns of Plasmodium falcip
High sensitivity detection of <em>Plasmodium</em> species reveals positive correlations between infections of different species, shifts in age... (Publications)
BACKGROUND: When diagnosed by standard light microscopy (LM), malaria prevalence can vary significantly between sites, even at local scale, and mixed species infections are consistently less common th
Ensemble modeling of the likely public health impact of a pre-erythrocytic malaria vaccine (Publications)
BACKGROUND: The RTS,S malaria vaccine may soon be licensed. Models of impact of such vaccines have mainly considered deployment via the World Health Organization's Expanded Programme on Immunization (