Induction of humoral immune response to multiple recombinant <em>Rhipicephalus appendiculatus</em> antigens and their effect on tick feeding success... (Publications)
BACKGROUND: Rhipicephalus appendiculatus is the primary vector of Theileria parva, the etiological agent of East Coast fever (ECF), a devastating disease of cattle in sub-Saharan Africa. We hypothesiz
Characterization of novel antimalarial compound ACT-451840: preclinical assessment of activity and dose-efficacy modeling (Publications)
BACKGROUND: Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of
Ivermectin treatment and sanitation effectively reduce <em>Strongyloides stercoralis</em> infection risk in rural communities in Cambodia (Publications)
BACKGROUND: Strongyloides stercoralis is the only soil-transmitted helminth with the ability to replicate within its host, leading to long-lasting and potentially fatal infections. It is ubiquitous an
Host-directed therapies for infectious diseases: current status, recent progress, and future prospects (Publications)
Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from
Population pharmacokinetic modeling of tribendimidine metabolites in <em>Opisthorchis viverrini</em>-infected adults (Publications)
There is a pressing need for alternative treatments against the liver fluke Opisthorchis viverrini Oral tribendimidine is a promising candidate, but its population pharmacokinetic properties are unkno
Catalyzing the scale-up of community-based primary healthcare in a rural impoverished region of northern Ghana (Publications)
Ghana's Community-based Health Planning and Services (CHPS) initiative develops accessible healthcare with participatory community support, using strategies developed and tested by a project of the Na
Burden and historical trend of Buruli ulcer prevalence in selected communities along the Offin River of Ghana (Publications)
Buruli ulcer (BU) is a neglected tropical skin disease caused by Mycobacterium ulcerans with more than two thirds of the global cases reported in West Africa. A nationwide active BU case search conduc
Limited genetic diversity of hepatitis B virus in the general population of the Offin River valley in Ghana (Publications)
Hepatitis B virus (HBV) infections account for approximately 780,000 deaths per year, most of which occur in the developing world. Co-infection with HBV and hepatitis delta virus (HDV) may lead to the