Effect of deworming on school-aged children's physical fitness, cognition and clinical parameters in a malaria-helminth co-endemic area of Côte... (Publications)
BACKGROUND: Malaria and helminth infections are thought to negatively affect children's nutritional status and to impair their physical and cognitive development. Yet, the current evidence-base is weak [...] helminthiasis and schistosomiasis on children's physical fitness, cognition and clinical parameters in a malaria-helminth co-endemic setting of Cote d'Ivoire. METHODS: We designed an intervention study with a 5-month [...] speculate that potential beneficial effects of deworming are likely...
Effective autodissemination of pyriproxyfen to breeding sites by the exophilic malaria vector <em>Anopheles arabiensis</em> in semi-field settings in... (Publications)
autodissemination of PPF to breeding habitats by malaria vectors. These findings highlight the potential for this technique for outdoor control of malaria vectors and call for the testing of this technique [...] BACKGROUND: Malaria vector control strategies that target adult female mosquitoes are challenged by the emergence of insecticide resistance and behavioural resilience. Conventional larviciding is restricted
The epidemiology of malaria and anaemia in the Bonikro mining area, central Côte d'Ivoire (Publications)
BACKGROUND: The epidemiology of malaria and anaemia is characterized by small-scale spatial and temporal heterogeneity, which might be influenced by human activities, such as mining and related disturbance [...] sector involvement holds promise to foster public health, including the prevention and control of malaria and anaemia. Here, results from a cross-sectional epidemiological survey, conducted in communities [...] haemoglobin (Hb) was measured to determine anaemia. Additionally, mothers...
An experimental hut study to quantify the effect of DDT and airborne pyrethroids on entomological parameters of malaria transmission (Publications)
BACKGROUND: Current malaria vector control programmes rely on insecticides with rapid contact toxicity. However, spatial repellents can also be applied to reduce man-vector contact, which might ultimately [...] ultimately impact malaria transmission. The aim of this study was to quantify effects of airborne pyrethroids from coils and DDT used an indoor residual spray (IRS) on entomological parameters that influence [...] influence malaria transmission. METHODS: The effect of Transfluthrin and...
Modelling heterogeneity in malaria transmission using large sparse spatio-temporal entomological data (Publications)
Background: Malaria transmission is measured using entomological inoculation rate (EIR), number of infective mosquito bites/person/unit time. Understanding heterogeneity of malaria transmission has been [...] database compiled by the Malaria Transmission Intensity and Mortality Burden across Africa (MTIMBA) project (2001-2004) at several sites is the most suitable dataset for studying malaria transmission-mortality [...] a rigorous approach for analysing large and highly variable entomological...
Comparative assessment of diverse strategies for malaria vector population control based on measured rates at which mosquitoes utilize targeted... (Publications)
BACKGROUND: Eliminating malaria requires vector control interventions that dramatically reduce adult mosquito population densities and survival rates. Indoor applications of insecticidal nets and sprays
A cluster-randomized controlled trial to assess the effectiveness of using 15% DEET topical repellent with long-lasting insecticidal nets (LLINs)... (Publications)
al nets (LLINs) have limited effect on malaria transmitted outside of sleeping hours. Topical repellents have demonstrated reduction in the incidence of malaria transmitted in the early evening. This study [...] likely a result of lack of statistical power, poor capture of malaria events or bias caused by imbalance in the SES of the two groups. Low malaria transmission during the study period could have masked the [...] study assessed whether 15% DEET topical repellent used in combination with...
Cost-effectiveness of intermittent preventive treatment of malaria in infants (IPTi) for averting anaemia in Gabon: a comparison between intention to... (Publications)
BACKGROUND: In Gabon, the impact of intermittent preventive treatment of malaria in infants (IPTi) was not statistically significant on malaria reduction, but the impact on moderate anaemia was, with some differences
A review of malaria vaccine clinical projects based on the WHO rainbow table (Publications)
As the malaria community considers the potential role of a first-generation malaria vaccine in malaria control efforts, it is an apposite time to carefully document terminated and ongoing malaria vaccine [...] Phase 3 testing of the most advanced malaria vaccine, RTS,S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of several research malaria vaccines have also confirmed that [...] applied to increase the chances of success for second-generation malaria...
Design and pre-clinical profiling of a <em>Plasmodium falciparum</em> MSP-3 derived component for a multi-valent virosomal malaria vaccine (Publications)
BACKGROUND: Clinical profiling of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in [...] is suitable for use in humans and represents a candidate component for a virosomal multi-valent malaria subunit vaccine