Dihydroartemisinin-piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in Tanzania (Publications)
course of DP for three consecutive months regardless of malaria infection status, and those in the control clusters received no intervention. Malaria infection was assessed at before the first-round and at [...] Effectiveness of dihydroartemisinin-piperaquine (DP) as seasonal malaria chemoprevention (SMC) was assessed in Nanyumbu and Masasi Districts. Between March and June 2021, children aged 3-59 months were [...] at 7 weeks after the third-round of DP in both arms. Malaria prevalence after...
Child health and infection with low density (CHILD) malaria: a protocol for a randomised controlled trial to assess the long-term health and... (Publications)
participants receive malaria testing using RDT and qPCR three times annually, and malaria testing by RDT only when presenting with fever. PCDm and PCD participants receive malaria testing by RDT and qPCR [...] INTRODUCTION: As malaria declines, low-density malaria infections (LMIs) represent an increasing proportion of infections and may have negative impacts on child health and cognition, necessitating development [...] respectively, when presenting with fever. RDT or qPCR positive...
Malaria treatment for prevention: a modelling study of the impact of routine case management on malaria prevalence and burden (Publications)
to explore how increasing treatment of symptomatic cases impacts malaria prevalence and incidence. METHODS: Leveraging the OpenMalaria stochastic agent-based transmission model, we first simulated an array [...] BACKGROUND: Testing and treating symptomatic malaria cases is crucial for case management, but it may also prevent future illness by reducing mean infection duration. Measuring the impact of effective [...] and 54% incorporated to reflect the 2023 coverage distribution across Africa, as...
Epidemiological characterization of malaria in rural southern Tanzania following China-Tanzania pilot joint malaria control baseline survey (Publications)
BACKGROUND: Malaria is an important public health problem in Tanzania. The latest national malaria data suggests rebound of the disease in the country. Anopheles arabiensis, a mosquito species renowned [...] conducted to determine malaria parasite prevalence and associated risk exposures prior to piloting the T3-initiative of World Health Organization integrated with Chinese malaria control experience aimed [...] additional reduction of malaria in the area. METHODS: The study was conducted from...
Malaria control across borders: quasi-experimental evidence from the Trans-Kunene malaria initiative (TKMI) (Publications)
BACKGROUND: The transmission of malaria through population inflows from highly endemic areas with limited control efforts poses major challenges for national malaria control programmes. Several multilateral [...] l efforts. CONCLUSIONS: The impact of malaria programmes depends on programme efforts in surrounding areas with differential control efforts. Coordinated malaria programming within and across countries [...] the potential impact of such a programme at the Angolan-Namibian border....
Whole blood transcriptome changes following controlled human malaria infection in malaria pre-exposed volunteers correlate with parasite prepatent... (Publications)
Malaria continues to be one of mankind's most devastating diseases despite the many and varied efforts to combat it. Indispensable for malaria elimination and eventual eradication is the development of [...] of effective vaccines. Controlled human malaria infection (CHMI) is an invaluable tool for vaccine efficacy assessment and investigation of early immunological and molecular responses against Plasmodium [...] cell cycle, phosphatidylinositol signaling and erythrocyte development. Our study...