High throughput multiplex assay for species identification of Papua New Guinea malaria vectors: members of the <em>Anopheles punctulatus</em>... (Publications)
Malaria and filariasis are transmitted in the Southwest Pacific region by Anopheles punctulatus sibling species including An. punctulatus, An. koliensis, the An. farauti complex 1-8 (includes An. hinesorum
A molecular marker of artemisinin-resistant <em>Plasmodium falciparum</em> malaria (Publications)
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular
Targeting <em>Plasmodium</em> PI(4)K to eliminate malaria (Publications)
Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH kinase (PI(4)K), as the [...] azines demonstrate potent preventive, therapeutic, and transmission-blocking activity in rodent malaria models, are active against blood-stage field isolates of the major human pathogens P. falciparum [...] to identify drugs with an ideal activity profile for the prevention, treatment and...
Epidemiology of malaria in the Papua New Guinean highlands (Publications)
Below 1400 m, malaria was a significant source of febrile illness. At higher altitudes, malaria was only a significant source of febrile illness during epidemic outbreaks, but asymptomatic malaria infections [...] investigation of the epidemiology of malaria in the Papua New Guinea (PNG) highlands and provide a basis for evidence-based planning and monitoring of intensified malaria control activities. Methods Between [...] and July 2005, 153 household-based, rapid malaria population surveys were...
Child mortality patterns in rural Tanzania: an observational study on the impact of malaria control interventions (Publications)
BACKGROUND: Between 1997 and 2009, a number of key malaria control interventions were implemented in the Kilombero and Ulanga Districts in south central Tanzania to increase insecticide-treated nets (ITN) [...] (ITN) coverage and improve access to effective malaria treatment. In this study we estimated the contribution of these interventions to observed decreases in child mortality. METHODS: The local Health and [...] security. We used Poisson regression with linear and segmented effects to...