Natural variation in timing of egg hatching, response to water agitation, and bidirectional selection of early and late hatching strains of the... (Publications)
variation in egg hatching and its environmental and genetic determinants in sibling species of the malaria vector Anopheles gambiae s.l. is important for understanding their adaptation to variable aquatic
Scalable camera traps for measuring the attractiveness of sugar baits for controlling malaria and dengue vectors (Publications)
BACKGROUND: Attractive targeted sugar baits (ATSBs) are promising new interventions that can complement existing vector control tools. However, reproducible and quantitative information on the level o
Travel to malaria-endemic areas: using digital geo-location to assess potential exposure risks and health behaviours (Publications)
and Tanzania, each presenting varying malaria risks. The extent to which travellers enter high-risk malaria-endemic areas in destinations with heterogeneous malaria risk remains unclear. We used geo-location [...] heterogeneous malaria risk (Brazil, India, Peru, Thailand), and (ii) compare mosquito bite prevention behaviours between these destinations and Tanzania, considered entirely high-risk for malaria. METHODS: [...] health and geo-location data were collected using a smartphone...
The influence of malaria control interventions and climate variability on changes in the geographical distribution of parasite prevalence in Kenya... (Publications)
The burden of malaria in Kenya was showing a declining trend, but appears to have reached a plateau in recent years. This study estimated changes in the geographical distribution of malaria parasite risk [...] contribution of malaria control interventions and climatic/ environmental factors to these changes. METHODS: Bayesian geostatistical models were used to analyse the Kenyan 2015 and 2020 Malaria Indicator Survey [...] coverage of most malaria indicators related to Insecticide Treated Nets...
Slow clearance of histidine-rich protein-2 in Gabonese with uncomplicated malaria (Publications)
Malaria rapid diagnostic tests (RDTs), which detect Plasmodium falciparum (Pf)-specific histidine-rich protein-2 (HRP2), have increasing importance for the diagnosis and control of malaria, especially [...] RDT-based assessment following a malaria treatment for weeks. A better understanding of the HRP2 clearance dynamics is critical for guiding the diagnosis of malaria when relying on RDTs. IMPORTANCE: Detecting [...] determine the long-term kinetic of HRP2-levels in peripheral blood after...
The impact of soil transmitted helminth on malaria clinical presentation and treatment outcome: a case control study among children in Bagamoyo... (Publications)
been documented between Plasmodium and STH. This study investigated the impact of STH on clinical malaria presentation and treatment outcome. METHODS: A matched case control study with a semi longitudinal [...] areas of Bagamoyo, coastal region of Tanzania. Cases were children with uncomplicated and severe malaria enrolled from the health facilities while controls were children with asymptomatic Plasmodium parasitemia [...] regression analysis there was a tendency for a protective effect of STH...
Investigating sulfoxide-to-sulfone conversion as a prodrug strategy for a phosphatidylinositol 4-kinas inhibitor in a humanized mouse model of malaria (Publications)
its corresponding sulfone metabolite, were evaluated in the NOD-scid IL2Rgamma(null) (NSG) murine malaria disease model of Plasmodium falciparum infection. We hypothesized that the sulfoxide would serve [...] dosed, thereby demonstrating that the sulfoxide served as an effective prodrug for the treatment of malaria.