A <em>var</em> gene promoter controls allelic exclusion of virulence genes in <em>Plasmodium falciparum</em> malaria (Publications)
proteins. In the apicomplexan parasite Plasmodium falciparum, responsible for the severe form of malaria in humans, this is exemplified by antigenic variation of the highly polymorphic P. falciparum erythrocyte
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants (Publications)
Background The candidate malaria vaccine RTS,S/AS01 reduced episodes of both clinical and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing phase 3 trial. We studied infants [...] only episode of clinical malaria during the 12 months after vaccination, a coprimary end point, was analyzed with the use of Cox regression. Vaccine efficacy against all malaria episodes, vaccine efficacy [...] efficacy against severe malaria, safety, and immunogenicity were also...