Innovative tools and OpenHDS for health and demographic surveillance on Rusinga Island, Kenya (Publications)
METHODS: A large trial investigating the effect of odour-baited mosquito traps on malaria vector populations and malaria transmission on Rusinga Island, western Kenya, has deployed an HDSS. By means of [...] DISCUSSION: Adopting innovative technological advancements has enabled the collection of demographic and malaria data quickly and effectively, with minimal margin for errors. Real-time data quality controls integrated
Comparative study of the effects of artemether and artesunate on juvenile and adult<em> Schistosoma mansoni</em> in experimentally infected mice (Publications)
stages of schistosome parasites. Since artemisinin derivatives will be increasingly used to treat malaria, it is important to study the effects of 7-day monotherapy regimens on schistosome infections. We [...] artemether or artesunate at various doses and regimens including those currently used for monotherapy of malaria. Three doses of artemether, at concentrations of 150 or 300 mg/kg, administered to mice with juvenile [...] discussions on the effect and use of artemisinin derivatives against...
<em>Plasmodium falciparum</em> merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic... (Publications)
allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates. The aim of the current study is to characterize the immune response (epitope [...] (epitope mapping) in naturally exposed individuals and relate immune responses to the risk of clinical malaria. METHODS: To optimize their construction, the fine specificity of human serum antibodies from donors [...] response to individual epitopes within the 3D7 family-specific region...
Urban agriculture and <em>Anopheles</em> habitats in Dar es Salaam, Tanzania (Publications)
than a fifth of all breeding sites of malaria vectors in Dar es Salaam. It is suggested that strategies comprising an integrated malaria control effort in malaria-endemic African cities include participatory
Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing (Publications)
Amodiaquine plus artesunate is the recommended antimalarial treatment in many malaria-endemic countries. However, pediatric doses are largely based on a linear extrapolation from adult doses. We pooled [...] amodiaquine, to optimize the dose across all age groups. Adults and children with uncomplicated malaria received daily weight-based doses of amodiaquine or artesunate-amodiaquine over three days. Plasma [...] 22.4% (15.6 - 31.9%) lower at the start of treatment than during convalescence,...
The mode of action of spatial repellents and their impact on vectorial capacity of<em> Anopheles gambiae sensu stricto</em> (Publications)
Malaria vector control relies on toxicity of insecticides used in long lasting insecticide treated nets and indoor residual spraying. This is despite evidence that sub-lethal insecticides reduce human-vector [...] human-vector contact and malaria transmission. The impact of sub-lethal insecticides on host seeking and blood feeding of mosquitoes was measured. Taxis boxes distinguished between repellency and attraction [...] target product profiles of spatial repellent products that can be used to...
Semi-field evaluation of a volatile transfluthrin-based intervention reveals efficacy as a spatial repellent and evidence of other modes of action (Publications)
Presently, the most common malaria control tools-i.e., long lasting insecticide-treated nets (LLINs) and indoor residual spraying (IRS)-are limited to targeting indoor biting and resting behaviors of Anopheles [...] Anopheles mosquito species. Few interventions are targeted towards malaria control in areas where transmission is driven or persists due to outdoor biting behaviors. This study investigated a volatile [...] Southern Province, Zambia, is one such environment where outdoor biting is...
Asymptomatic <em>Plasmodium</em> infection and glycemic control in adults: results from a population-based survey in south-central Côte d'Ivoire (Publications)
associations of Plasmodium infection (PI) with fasting glucose (FG) and glycated hemoglobin (HbA1c) in malaria-endemic south-central Cote d'Ivoire. METHODS: We studied 979 participants (non-pregnant; no treated [...] Fasting venous blood was obtained for PI, FG, and HbA1c assessment. We defined PI as a positive malaria rapid diagnostic test (RDT) or microscopic identification of Plasmodium species. We applied multivariable [...] diagnosis in the presence of asymptomatic PI may misclassify or...
Mosquito net use in early childhood and survival to adulthood in Tanzania (Publications)
BACKGROUND It has been hypothesized that in high-transmission settings, malaria control in early childhood (
Mosquito net use in early childhood and survival to adulthood in Tanzania (Publications)
BACKGROUND It has been hypothesized that in high-transmission settings, malaria control in early childhood (