Infection Biology and Molecular Epidemiology | Swiss TPH (Page)
https://www.swisstph.ch/fr/infection-biology-and-molecular-epidemiology
infectious diseases. In the field of the life sciences, Swiss TPH places particular emphasis on malaria, tuberculosis and other poverty-related infectious diseases. We utilise state-of-the-art basic research [...] of new drugs, diagnostics and vaccines. Helminths HIV/AIDS Human African Trypanosomiasis (HAT) Malaria Neglected Tropical Diseases (NTDs) Tuberculosis
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy (Publications)
the malaria parasite Plasmodium falciparum, namely tyrosine RS (PfYRS). ML901 exerts whole-life-cycle-killing activity with low nanomolar potency and single-dose efficacy in a mouse model of malaria. X-ray
Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast-killing kinetics and <em>in vivo</em> efficacy in the... (Publications)
SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During [...] Frontrunner compound 37 showed good exposure in mice combined with good in vitro activity against the malaria parasite, which translated into in vivo efficacy in the P. falciparum NOD-scid IL-2Rgamma(null) (NSG)
Delayed anemia after treatment with injectable artesunate in the democratic republic of the Congo: a manageable issue (Publications)
treatment of severe malaria. A total of 350 patients (215 [61.4%] < 5 years of age and 135 [38.6%] > /= 5 years of age) were followed-up after treatment with injectable artesunate for severe malaria in hospitals
Probing <em>Plasmodium falciparum</em> sexual commitment at the single-cell level (Publications)
Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure. Here we apply single cell transcriptomics to unravel [...] programs, with important implications for our understanding of parasite biology and the ongoing malaria elimination campaign.
Pharmacophore model for pentamidine analogs active against <em>Plasmodium falciparum</em> (Publications)
to be active against Plasmodium falciparum, which causes the most dangerous malarial infection. Malaria is a widespread disease known to affect hundreds of millions of people and presents a perceivable [...] polar oxygen and amidine substituents and the hydrophobic linking chain for the activity against malaria
New algorithm for managing childhood illness using mobile technology (ALMANACH): a controlled non-inferiority study on clinical outcome and antibiotic... (Publications)
INTRODUCTION: The decline of malaria and scale-up of rapid diagnostic tests calls for a revision of IMCI. A new algorithm (ALMANACH) running on mobile technology was developed based on the latest evidence [...] (387%) in control arm were diagnosed with an infection in need for antibiotic, while 38% and 96% had malaria. 815/838 (973%;961-98.4%) were cured at D7 using ALMANACH versus 573/623 (920%;898-941%) using standard
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy (Publications)
the malaria parasite Plasmodium falciparum, namely tyrosine RS (PfYRS). ML901 exerts whole-life-cycle-killing activity with low nanomolar potency and single-dose efficacy in a mouse model of malaria. X-ray
Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast-killing kinetics and <em>in vivo</em> efficacy in the... (Publications)
SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During [...] Frontrunner compound 37 showed good exposure in mice combined with good in vitro activity against the malaria parasite, which translated into in vivo efficacy in the P. falciparum NOD-scid IL-2Rgamma(null) (NSG)
Delayed anemia after treatment with injectable artesunate in the democratic republic of the Congo: a manageable issue (Publications)
treatment of severe malaria. A total of 350 patients (215 [61.4%] < 5 years of age and 135 [38.6%] > /= 5 years of age) were followed-up after treatment with injectable artesunate for severe malaria in hospitals
