Fast-killing tyrosine amide ((<em>S</em>)-SW228703) with blood- and liver-stage antimalarial activity associated with the cyclic amine resistance... (Publications)
Current malaria treatments are threatened by drug resistance, and new drugs are urgently needed. In a phenotypic screen for new antimalarials, we identified (S)-SW228703 ((S)-SW703), a tyrosine amide with [...] fast-killing mechanism of action, available for lead optimization to generate new treatments for malaria.
Addressing the intracellular vestibule of the plasmodial lactate transporter PfFNT by p-substituted inhibitors amplifies in vitro activity (Publications)
Inhibition of the lactate transporter PfFNT is a valid novel mode of action against malaria parasites. Current pyridine-substituted pentafluoro-3-hydroxy-pent-2-en-1-ones act as substrate analogs with [...] metabolized, the more stable p-acetanilide cleared 99.7% of parasites at 4 × 50 mg kg(-1) in a mouse malaria model. Future stabilization of the p-substitution against metabolism may translate the gain in in
The catalytic subunit of <em>Plasmodium falciparum</em> casein kinase 2 is essential for gametocytogenesis (Publications)
pleiotropic kinase phosphorylating substrates in different cellular compartments in eukaryotes. In the malaria parasite Plasmodium falciparum, PfCK2 is vital for asexual proliferation of blood-stage parasites [...] PfCK2alpha catalytic subunit in gametocytes, the sexual forms of the parasite that are essential for malaria transmission. We show that PfCK2alpha localizes to the nucleus and cytoplasm in asexual and sexual
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13th Annual Roll Back Malaria Vector Control Working Group Meeting We kindly ask you to complete the registration form, including the registration fee payment (CHF 250.- per person), latest by December
Basic Research in Infection Biology | Swiss TPH (Page)
https://www.swisstph.ch/fr/research/basic-research-in-infection-biology
are neglected tropical diseases that affect the poorest communities. Malaria A gametocyte - the sexual form of Plasmodium Malaria is caused by unicellular parasites of the genus Plasmodium , which are [...] Infection Biology conduct cutting-edge basic research on infectious diseases of poverty, including Malaria (caused by Plasmodium spp .) Tuberculosis (caused by Mycobacterium tuberculosis ) Buruli ulcer (caused [...] Mycobacterium ulcerans ) Sleeping sickness/African trypanosomiasis (caused...
Surveillance of molecular markers of <em>Plasmodium falciparum</em> artemisinin resistance (<em>kelch</em>13 mutations) in Papua New Guinea between... (Publications)
Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) is a global threat to malaria control and elimination efforts. Mutations in the P. falciparum kelch13 gene (Pfk13) that are associated [...] in other parts of PNG is unknown. We investigated the prevalence of Pfk13 mutations in multiple malaria-endemic regions of PNG. P. falciparum isolates (n = 1152) collected between 2016 and 2018 and assessed [...] Continued surveillance for molecular markers of drug resistance is...
The development of an ivermectin-based attractive toxic sugar bait (ATSB) to target <em>Anopheles arabiensis</em> (Publications)
Africa are moving towards malaria-elimination, mostly thanks to successful vector control campaigns. However, elimination has proven challenging, resulting in the persistence of malaria transmission. It is now [...] now accepted that in order to eliminate malaria, new complementary vector control approaches must be developed. This study describes the development of a sugar-baited resting place containing a toxic dose
Molecular methods for tracking residual <em>Plasmodium falciparum </em>transmission in a close-to-elimination setting in Zanzibar (Publications)
essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore [...] screening large sample sets represents primarily a research tool that should inform the design of malaria elimination strategies. It may also prove beneficial for diagnostic tasks in surveillance-response
Effects of changing mosquito host searching behaviour on the cost effectiveness of a mass distribution of long-lasting, insecticidal nets: a modelling... (Publications)
BACKGROUND: The effectiveness of long-lasting, insecticidal nets (LLINs) in preventing malaria is threatened by the changing biting behaviour of mosquitoes, from nocturnal and endophagic to crepuscular [...] stochastic simulation models, we studied the impact of a mass LLIN distribution on Plasmodium falciparum malaria. Specifically, we looked at impact in terms of episodes prevented during the effective life of the [...] occur within the same mosquito population. LLINs are likely cost effective...
Infection and co-infection with helminths and <em>Plasmodium</em> among school children in Côte d'Ivoire: results from a national cross-sectional... (Publications)
Helminth infection and malaria remain major causes of ill-health in the tropics and subtropics. There are several shared risk factors (e.g., poverty), and hence, helminth infection and malaria overlap geographically [...] provide a rationale to combine control interventions that simultaneously aim at helminthiases and malaria