Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the plasmodium life cycle (Publications)
Quinolines are excellent ligands for metal coordination and are deployed as drugs for malaria treatment. There is a growing body of evidence indicating that metal complexes can be conjugated with antimalarial [...] findings indicate that metal coordination is a potential chemical tool for drug design and discovery in malaria.
A community-randomised evaluation of the effect of IPTi on anti-malarial drug resistance in southern Tanzania (Publications)
is the administration of sulphadoxine-pyrimethamine (SP) at 2, 3 and 9 months of age to prevent malaria. We investigated the influence of IPTi on drug resistance.Methods. Twenty-four areas were randomized [...] did not increase drug pressure, or the selection on dhfr and dhps mutants, when SP was first line malaria treatment. Introduction of artemether-lumefantrine was followed by an increase in dhfr mutations
Dynamics of anemia in relation to parasitic infections, micronutrient status, and growing age in south-central Côte d'Ivoire (Publications)
Background. Parasitic diseases (e.g., malaria and helminthiases) exert enormous burdens on public health and social wellbeing. Moreover, parasitic infections are important causes of anemia in tropical [...] include the distribution of long-lasting insecticidal nets, intermittent preventive treatment for malaria, regular anthelmintic drug administration, and improved intake of bioavailable iron, coupled with
Antiprotozoal <em>Nor</em>-triterpene alkaloids from <em>Buxus sempervirens</em> L (Publications)
Malaria and human African trypanosomiasis (HAT; sleeping sickness) are life-threatening tropical diseases caused by protozoan parasites. Due to limited therapeutic options, there is a compelling need for [...] was identified as possessing strong and selective in vitro activity against the causative agent of malaria tropica, Plasmodium falciparum (Pf). The purpose of this study is the isolation of additional alkaloids
Field-caught permethrin-resistant <em>Anopheles gambiae</em> overexpress CYP6P3, a P450 that metabolises pyrethroids (Publications)
Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is receiving increasing attention because it threatens the sustainability of malaria vector control programs in sub-Saharan Africa
Proteomic analysis of exported chaperone/co-chaperone complexes of <em>P. falciparum</em> reveals an array of complex protein-protein interactions (Publications)
Malaria parasites modify their human host cell, the mature erythrocyte. This modification is mediated by a large number of parasite proteins that are exported to the host cell, and is also the underlying [...] underlying cause for the pathology caused by malaria infection. Amongst these proteins are many Hsp40 co-chaperones, and a single Hsp70. These proteins have been implicated in several processes in the host cell
Epidemiology of multiple <em>Plasmodium falciparum</em> infections. 6. Multiple <em>Plasmodium falciparum</em> infections in Tanzanian infants (Publications)
clinical malaria, in contrast to the situation in older children (> 2 years). The findings help in the understanding of infection dynamics, premunition, and development of semi-immunity in malaria.
Do bednets including piperonyl butoxide offer additional protection against populations of<em> Anopheles gambiae s.l. </em>that are highly resistant... (Publications)
Malaria control is dependent on the use of longlasting insecticidal nets (LLINs) containing pyrethroids. A new generation of LLINs containing both pyrethroids and the synergist piperonyl butoxide (PBO) [...] (PBO) has been developed in response to increasing pyrethroid resistance in African malaria vectors, but questions remain about the performance of these nets in areas where levels of pyrethroid resistance
Health & demographic surveillance system profile: the Taabo Health and Demographic Surveillance System, Côte d'Ivoire (Publications)
ed diseases such as schistosomiasis and malaria. The Taabo HDSS has generated setting-specific evidence on the impact of targeted interventions against malaria, schistosomiasis and other neglected tropical
Molecular surveillance of the antifolateresistant mutation I164L in imported African isolates of <em>Plasmodium falciparum</em> in Europe: sentinel... (Publications)
BACKGROUND: Malaria parasites that carry the DHFR-mutation I164L are not only highly resistant to sulfadoxine-pyrimethamine but also to the new antimalarial drug chlorproguanil-dapsone. The spread of this [...] network for the surveillance of travel-associated diseases and seems to cover approximately 12% of all malaria cases imported into Europe. Within this network we screened 277 imported African isolates of P.
