New myxobacteria of the <em>Myxococcaceae</em> clade produce angiolams with antiparasitic activities (Publications)
named angiolams B, C, and D were found to display promising antiparasitic activities against the malaria pathogen Plasmodium falciparum in the 0.3-0.8 µM range.IMPORTANCEThe COVID-19 pandemic and continuously [...] diseases. However, the shortage of treatment options against protozoal parasitic infections, like malaria, is much more severe, especially for the treatment of so-called neglected tropical diseases. The
Combating poor‑quality anti‑malarial medicines: a call to action (Publications)
medicines appear to have been particularly compromised and present a major public health threat in malaria-endemic countries, negatively affecting individuals and their communities. Concerted collaborative [...] their actions in these critical areas and thus effectively support global health development and malaria elimination programmes.
Antiprotozoal activities of tetrazole-quinolines with aminopiperidine linker (Publications)
sickness) and Malaria both are insect vectored tropical diseases. Only a couple of drugs is able to cure HAT, but all of them are toxic, prone to resistance and require parenteral administration. Malaria is responsible
Can trials of spatial repellents be used to estimate mosquito movement? (Publications)
Knowledge of mosquito movement would aid the design of effective intervention strategies against malaria. However, data on mosquito movement through mark-recapture or genetics studies are challenging to [...] method may supplement those from mark-release-recapture studies, and be used in designing effective malaria intervention strategies, parameterizing mathematical models and in designing trials of vector control
Multiplicity of <em>Plasmodium falciparum</em> infection following intermittent preventive treatment in infants (Publications)
Intermittent preventive treatment in infants with sulphadoxine-pyrimethamine (IPTi-SP) reduces malaria morbidity by 20% to 33%. Potentially, however, this intervention may compromise the acquisition of [...] of polyclonal infections (69.6% vs. 69.7%; P = 0.99). Adjusting for study site, current and prior malaria, parasite density, and season did not change this finding. CONCLUSIONS: IPTi-SP appears to have no
First detection of N1575Y mutation in pyrethroid resistant <em>Anopheles gambiae</em> in Southern Côte d'Ivoire (Publications)
insecticide classes is widespread. In an agricultural area of Southern Cote d'Ivoire, the main malaria vector Anopheles coluzzii shows multiple resistance across insecticides mediated by both target site [...] mutation in Cote d'Ivoire, and as in other populations, it is found in both dominant West African malaria vector species. Continued monitoring of N1575Y is underway, as are studies to elucidate its contribution
Very high carriage of gametocytes in asymptomatic low-density <em>Plasmodium falciparum</em> and <em>P. vivax</em> infections in western Thailand (Publications)
Plasmodium spp. are common in low endemicity areas worldwide, but outside Africa, their contribution to malaria transmission is poorly understood. Community-based studies with highly sensitive molecular diagnostics [...] gametocytes indicates that these infections may contribute substantially to the maintenance of local malaria transmission.
<em>Plasmodium vivax</em> and <em>Plasmodium falciparum</em> infection dynamics: re-infections, recrudescences and relapses (Publications)
BACKGROUND: In malaria endemic populations, complex patterns of Plasmodium vivax and Plasmodium falciparum blood-stage infection dynamics may be observed. Genotyping samples from longitudinal cohort studies [...] CONCLUSION: The statistical model developed here provides a useful new tool for in-depth analysis of malaria data from longitudinal cohort studies, and future application to data sets with multi-locus genotyping
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part I (Publications)
neglect of public awareness in high income countries. Another major tropical protozoan disease is malaria (caused by various Plasmodium species), which -although not mentioned currently by the WHO as a neglected [...] represents a major problem, especially to people living under poor circumstances in tropical countries. Malaria causes by far the highest number of deaths of all protozoan infections and is often (as in this review)
Interactions and potential implications of <em>Plasmodium falciparum</em>-hookworm coinfection in different age groups in south-central Côte... (Publications)
these parasitic infections is of public health relevance considering that control measures targeting malaria and helminthiases are going to scale.METHODOLOGY: A cross-sectional survey was carried out in April [...] information could have important implications when implementing integrated control measures against malaria and helminthiases.