Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in <em>Plasmodium falciparum</em> (Publications)
The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host immune responses through switching expression of variant surface proteins encoded by the var gene family. We demonstrate
Modifications and hybrids of 1,2,3,4‑tetrahydropyridinium salts and their antiprotozoal potencies (Publications)
were investigated for their activity against Plasmodium falciparum NF54, a causative organism of Malaria tropica and Trypanosoma brucei rhodesiense, the causative organism of Human African Trypanosomiasis
Arthropod Testing Facility | Swiss TPH (Page)
https://www.swisstph.ch/fr/services/arthropod-testing-facility
Mosquitoes on Behalf of Target Malaria ViALLIN MUsAcc - Visual Analysis of Long Lasting Insecticidal Nets to Maximise Universal Access Related Topics Infectious Diseases Malaria Human African Trypanosomiasis
Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent <em>Schistosoma haematobium </em>infections (Publications)
microhematuria and macrohematuria were assessed 3 weeks after the final dosing. We also monitored malaria parasitemia and treated positive cases with sulfadoxine-pyrimethamine (SP). Oral artemether was well [...] 0.001). Heavy S. haematobium infections, microhematuria and macrohematuria, and the incidence of malaria parasitemia were all significantly lower in artemether recipients. In conclusion, previous findings
Identification of oleamide in <em>Guatteria</em> recurvisepala by LC/MS-Based <em>Plasmodium falciparum</em> thioredoxin reductase ligand binding... (Publications)
current research on applications of mass spectrometry to natural product drug discovery against malaria aims to screen plant extracts for new ligands to PLASMODIUM FALCIPARUM thioredoxin reductase ( PFTrxR) [...] regulation of the parasite and is validated as a promising target for therapeutic intervention against malaria. In the present study, detannified methanol extracts from GUATTERIA RECURVISEPALA, LICANIA KALLUNKIAE
Attractive toxic sugar baits for controlling mosquitoes: a qualitative study in Bagamoyo, Tanzania (Publications)
BACKGROUND: Malaria elimination is unlikely to be achieved without the implementation of new vector control interventions capable of complementing insecticide-treated nets and indoor residual spraying [...] and provides important information for future trials investigating the efficacy of ATSBs against malaria. This new vector control tool will require sensitization at community level regarding its mode of
Understanding the gap between access and use: a qualitative study on barriers and facilitators to insecticide-treated net use in Ghana (Publications)
a lack of information on the connection between the use of ITNs and malaria prevention. Falling ill or losing a loved one to malaria was the most powerful motivator for consistent ITN use. Participants
An evidence synthesis approach for combining different data sources illustrated using entomological efficacy of insecticides for indoor residual... (Publications)
BACKGROUND: Prospective malaria public health interventions are initially tested for entomological impact using standardised experimental hut trials. In some cases, data are collated as aggregated counts [...] residual spray (IRS) product active ingredient, used on wall surfaces to kill mosquitoes and reduce malaria transmission, were analysed using a series of statistical models to understand the benefits and
Elimination of <em>Schistosoma mansoni</em> in infected mice by slow release of artemisone (Publications)
anti-plasmodial activity, and reduced toxicity compared to other artemisinins in clinical use against malaria. We infected adult mice by subcutaneous injection of S. mansoni cercariae (about 200) and treated [...] release of the artemisone that was verified in vivo and in vitro bioassays using drug-sensitive malaria parasites. We found superior strong anti-schistosome effects up to a total reduction of worm number
Mapping of research on maternal health interventions in low- and middle-income countries: a review of 2292 publications between 2000 and 2012 (Publications)
systems strengthening, health promotion; and on five tracer conditions (haemorrhage, hypertension, malaria, HIV and other sexually transmitted infections (STIs)). Following review of 35,078 titles and abstracts [...] More than half the studies were done in sub-Saharan Africa (55.4 %), mostly addressing HIV and malaria. This region had low numbers of publications per hypertension and haemorrhage deaths, though South