malERA: an updated research agenda for health systems and policy research in malaria elimination and eradication (Publications)
effectiveness of interventions ('effectiveness decay'), and respond to dynamic and changing needs. The malaria eradication research agenda (malERA) Refresh consultative process for the Panel on Health Systems [...] Research identifies opportunities to build health systems evidence and the tools needed to eliminate malaria from different zones, countries, and regions and to eradicate it globally. The research questions [...] include delivery strategies to meet the changing dynamics of needs of...
Development of amplicon deep sequencing markers and data analysis pipeline for genotyping multi-clonal malaria infections (Publications)
BACKGROUND: Amplicon deep sequencing permits sensitive detection of minority clones and improves discriminatory power for genotyping multi-clone Plasmodium falciparum infections. New amplicon sequenci
malERA: an updated research agenda for malaria elimination and eradication (Publications)
burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the [...] goals, sustain elimination, and free the world of malaria is greater than ever. Over 180 experts across multiple disciplines are engaged in the Malaria Eradication Research Agenda (malERA) Refresh process [...] solved. The result is a research and development agenda to accelerate malaria...
The ethics of health care delivery in a pediatric malaria vaccine trial: the perspectives of stakeholders from Ghana and Tanzania (Publications)
care to participants and communities of low-resource settings involved in a Phase II/III pediatric malaria vaccine trial (PMVT). We conducted 52 key informant interviews with major stakeholders of an int
Attacking the mosquito on multiple fronts: insights from the vector control optimization model (VCOM) for malaria elimination (Publications)
nets (ITNs) and indoor residual spraying (IRS) in reducing malaria transmission, it is unlikely these tools will be sufficient to eliminate malaria transmission on their own in many settings today. Fortunately [...] performed for the main three malaria vectors in sub-Saharan Africa, Anopheles gambiae s.s, An. arabiensis and An. funestus. We considered areas having low, moderate and high malaria transmission, corresponding [...] however, there is growing evidence and consensus that effective...
Longitudinal estimation of <em>Plasmodium falciparum </em>prevalence in relation to malaria prevention measures in six sub-Saharan African countries (Publications)
(PfPR) is a widely used metric for assessing malaria transmission intensity. This study was carried out concurrently with the RTS,S/AS01 candidate malaria vaccine Phase III trial and estimated PfPR over [...] 3 sites. Surveys were usually performed during the peak malaria parasite transmission season, in one home visit, when medical history and malaria risk factors/prevention measures were collected, and a blood [...] 0.52, 0.68, 0.41) and bed net use in 2 surveys (ORs: 0.63, 0.68, 1.03, 1.78)...
Multiple insecticide resistance in <em>Anopheles gambiae</em> from Tanzania: a major concern for malaria vector control (Publications)
development of insecticide resistance in the major malaria vectors. This study was carried out to monitor the susceptibility status of major malaria vectors to insecticides used for IRS and LLINs in mainland [...] BACKGROUND: Malaria vector control in Tanzania is based on use of long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS), which both rely on the use of chemical insecticides. [...] An. gambiae sensu stricto (s.s.) Kisumu strain. RESULTS: Anopheles arabiensis...
Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite <em>Plasmodium falciparum</em> (Publications)
bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes [...] activation of sexual-stage-specific transcription and gametocyte formation. Our results reveal that malaria parasites can sense and process host-derived physiological signals to regulate differentiation. These [...] of the sexual differentiation pathway in Plasmodium that may provide...
