Prevalence and risk factors for malaria in pregnancy in Vanga, Democratic Republic of Congo (Publications)
(DRC) is the second most malarious country in the world, but little information is available on malaria control measures in pregnancy. We conducted a longitudinal study among 395 women pregnant with singletons [...] Vanga Health Zone, Kwilu Province. We recruited 406 pregnant women between April and October 2019. Malaria prevalence at recruitment was 18.8% in Vanga and 30.1% in Mayoko (difference p
Delayed cerebellar ataxia, a rare post-malaria neurological complication: case report and review of the literature (Publications)
Delayed cerebellar ataxia (DCA) is a rare post-malarial neurological complication with unknown pathomechanism characterized by its self-limiting course and favorable outcome. We report a case of DCA f
The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites (Publications)
t protein kinase A (PKA) signalling is essential for the proliferation of Plasmodium falciparum malaria blood stage parasites. The mechanisms regulating the activity of the catalytic subunit PfPKAc, however [...] function has not been investigated in gametocytes, the sexual blood stage forms that are essential for malaria transmission. By studying a conditional PfPKAc knockdown (cKD) mutant, we confirm the essential role
Effect of interventions to reduce malaria incidence among military personnel on active duty: study protocol for a cluster randomised controlled trial... (Publications)
studies assessing the impact on malaria infection. This study will estimate the protective efficacy of treated uniforms and DEET insect repellent on the incidence of malaria infection among military personnel [...] placebo-controlled trial is planned to evaluate the effectiveness of the interventions on preventing malaria infections in soldiers on active duty at Mgambo National Service Camp in Tanga, Tanzania. The arms [...] untreated uniforms with placebo lotion. The primary outcome is the...
Characterising co-infections with <em>Plasmodium </em>spp., <em>Mansonella perstans</em> or <em>Loa loa </em>in asymptomatic children, adults and... (Publications)
Equatorial Guinea are lacking. We aimed to demonstrate that blood retained on malaria rapid diagnostic tests, commonly deployed for malaria surveys, could be used as a source of nucleic acids for molecular based [...] with malaria in an asymptomatic population. METHODOLOGY: M. perstans, L. loa and Plasmodium spp. parasites were monitored by qPCR in a cross-sectional study using DNA extracted from a subset malaria rapid [...] rapid diagnostic tests (mRDTs) collected during the annual malaria...
Analysis of nucleic acids extracted from rapid diagnostic tests reveals a significant proportion of false positive test results associated with recent... (Publications)
Surveillance programmes often use malaria rapid diagnostic tests (RDTs) to determine the proportion of the population carrying parasites in their peripheral blood to assess the malaria transmission intensity. Despite [...] quality control activities for RDTs deployed in malaria surveillance programmes. Methods: The diagnostic performance of field-deployed RDTs used for malaria surveys was assessed by retrospective molecular [...] P. falciparum histidine rich protein 2 (PfHRP2) antigen...
Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study (Publications)
ted BTM correlations with malaria risk appeared to generalize to healthy, malaria-naive adults. CONCLUSIONS: A prevaccination transcriptomic signature associates with malaria in RTS,S/AS01-vaccinated African [...] we assessed the generalizability of our findings across three controlled human malaria infection studies of healthy, malaria-naive adult RTS,S/AS01 recipients. RESULTS: RTS,S/AS01 vaccination was associated [...] month 3 levels correlated with malaria risk. In contrast, baseline levels...
Haematological consequences of acute uncomplicated <em>falciparum </em>malaria: a WorldWide Antimalarial Resistance Network pooled analysis of... (Publications)
falciparum malaria to identify the factors associated with malarial anaemia. METHODS: Individual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available [...] BACKGROUND: Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of [...] = 2.06 [95%CI 1.39-3.05], p < 0.001). CONCLUSIONS: In patients with uncomplicated...