Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02D malaria vaccine in infants living in a... (Publications)
BACKGROUND: The RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization [...] compared to control. According to protocol population, vaccine efficacy against multiple episodes of malaria disease was 50.7% (95% CI: -6.5 to 77.1, p = 0.072) and 26.7% (95% CI: -33.1 to 59.6, p = 0.307) [...] to Treat population, over the 20-month follow up, vaccine efficacy against...
Potential for reduction of burden and local elimination of malaria by reducing <em>Plasmodium falciparum</em> malaria transmission: a mathematical... (Publications)
a mathematical model of the transmission of Plasmodium falciparum malaria to explore the potential effect on case incidence and malaria mortality rates from 2015 to 2030 of five different intervention [...] BACKGROUND: Rapid declines in malaria prevalence, cases, and deaths have been achieved globally during the past 15 years because of improved access to first-line treatment and vector control. We aimed [...] with a switch from quinine to injectable artesunate for management of severe disease...
Malaria molecular epidemiology: lessons from the International Centers of Excellence for Malaria Research Network (Publications)
and distribution of malaria cases. This article describes molecular epidemiologic investigations currently being carried out by the International Centers of Excellence for Malaria Research (ICEMR) network [...] network in a variety of malaria-endemic settings. First, we discuss various novel approaches to understand malaria incidence and gametocytemia, focusing on Plasmodium falciparum and Plasmodium vivax. Second [...] methods commonly used in malaria epidemiology and population genetics....
Intravenous artesunate reduces parasite clearance time, duration of intensive care and hospital treatment in patients with severe malaria in Europe:... (Publications)
Intravenous artesunate improves survival in severe malaria, but clinical trial data from non-endemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate [...] clearance time, duration of ICU- and hospital treatment in European patients with imported severe malaria
The incidence of malaria in travellers to South-East Asia: is local malaria transmission a useful risk indicator? (Publications)
strategy of using malaria transmission in a local population was an accurate estimate of the malaria threat faced by travellers and a correlate of malaria in returning travellers. METHODS: Malaria endemicity [...] the period 2003-2008 from regionally reported cases to WHO offices. Travel acquired malaria was collated from malaria surveillance reports from the USA and 12 European countries over the same period. The [...] countries, mean malaria rates in endemic countries ranged between 0.01 in...
Comprehensive sterilization of malaria vectors using pyriproxyfen: a step closer to malaria elimination (Publications)
One of the main challenges to malaria elimination is the resilience of vectors, such as Anopheles arabiensis, that evade lethal exposure to insecticidal control measures or express resistance to their