Transmission electron microscopic observations on ultrastructural damage in juvenile <em>Schistosoma mansoni</em> caused by artemether (Publications)
Artemether, a derivative of the antimalarial artemisinin, has been shown to induce rapid and extensive alteration to the tegument of juvenile Schistosoma japonicum, S. mansoni and S. haematobium. Less
Spatial-temporal and cancer risk assessment of selected hazardous air pollutants in Seattle (Publications)
In the Seattle Air Toxics Monitoring Pilot Program, we measured 15 hazardous air pollutants (HAPs) at 6 sites for more than a year between 2000 and 2002. Spatial-temporal variations were evaluated wit
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
Pyrimidine metabolism is a major route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite
Identification of fecal input sites in spring water by selection and genotyping of multiresistant <em>Escherichia coli</em> (Publications)
The localization of fecal input sites is important for water quality management. For this purpose, we have developed a new approach based on a three-step procedure, including a preparatory phase, the
Potential long-term toxicity of repeated orally administered doses of artemether in rats (Publications)
Artemether, an efficacious antimalarial drug, effectively prevents patent schistosome infections and morbidity, as established in laboratory models and in clinical trials. In view of concern about the
Assessing health impacts in complex eco-epidemiological settings in the humid tropics: advancing tools and methods (Publications)
In the developing world. large-scale projects in the extractive industry and natural resources sectors are often controversial and associated with long-term adverse health consequences to local commun
Novel <em>Bacteroides</em> host strains for detection of human- and animal-specific bacteriophages in water (Publications)
Bacteriophages active against specific Bacteroides host strains were shown to be suitable for detection of human faecal pollution. However, the practical application of this finding is limited because