La malaria importée en Suisse 1974-1976 (Publications)
month after the return from the infection area, malaria is only recognized late. The diagnosis is nevertheless relatively easy if the possibility of malaria is borne in mind [...] or not at all informed about the dangers and possible prophylaxis of infection. This is true for malaria, of which 207 cases covering the years 1974 to 1976 are studied. Most involved were people between [...] antimalarial drug. All the severe cases were in this group. A review is conducted of aspects of malaria in...
Inhibition of dendritic cell maturation by malaria is dose dependent and does not require<em> Plasmodium falciparum</em> erythrocyte membrane protein... (Publications)
Red blood cells infected with Plasmodium falciparum (iRBCs) have been shown to modulate maturation of human monocyte-derived dendritic cells (DCs), interfering with their ability to activate T cells.
Antibody and T cell responses associated with experimental human malaria infection or vaccination show limited relationships (Publications)
examined specific antibody and T cell responses associated with experimental malaria infection or malaria vaccination, in malaria-naive human volunteers within phase I/IIa vaccine trials, with a view to [...] investigating inter-relationships between these types of response. Malaria infection was via 5 bites of Plasmodium falciparum-infected mosquitos, with individuals reaching patent infection by 11-12 days [...] class switching was seen from an early IgM to an IgG1-dominant response of...
Pharmacokinetics-pharmacodynamics analysis of spiroindolone analogs and KAE609 in a murine malaria model (Publications)
selected class representative. Dose-response efficacy studies were conducted in the P. berghei murine malaria model and the relationship between dose and efficacy (i.e. reduction in parasitemia) was examined [...] of 30 are likely to result in maximum reduction in parasitemia in the P. berghei mouse model of malaria. This information could be used to prioritize analogs within the same class of compounds and contribute