First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children (Publications)
vaccination with either RTS,S/AS01 or a non-malaria comparator vaccine. The primary end point of the analysis was vaccine efficacy against clinical malaria during the 12 months after vaccination in the [...] vaccine according to protocol. After 250 children had an episode of severe malaria, we evaluated vaccine efficacy against severe malaria in both age categories. Results In the 14 months after the first dose [...] against severe malaria was 45.1% (95% CI, 23.8 to 60.5) in the...
A low-cost mesocosm for the study of behaviour and reproductive potential in Afrotropical mosquito (Diptera: Culicidae) vectors of malaria (Publications)
ss for use in experiments on behaviour, reproduction and adult survivorship in the Afrotropical malaria vector Anopheles gambiae s.s. Giles (Diptera: Culicidae) in temperate climates. The large space (82
Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1 (Publications)
extensive preclinical evaluation of its coiled coil peptides Tex1 was identified as promising novel malaria vaccine candidate providing the rational for a comprehensive cell biological characterization of
Varying efficacy of intermittent preventive treatment for malaria in infants in two similar trials: public health implications (Publications)
in the risk of clinical malaria between the second and the third dose; during the same period, there was no significant effect in Manhica. Similarly, protection against malaria episodes was maintained [...] explanation for the difference in IPTi efficacy on clinical malaria. Combination of IPTi and ITNs may be the most cost-effective tool for malaria control currently available, and needs to be explored in current [...] (IPTi) with sulphadoxine-pyrimethamine (SP) in infants resulted in different...
Dynamics of socioeconomic risk factors for neglected tropical diseases and malaria in an armed conflict (Publications)
and assessed the dynamics of socioeconomic risk factors for neglected tropical diseases (NTDs) and malaria. METHODOLOGY: The same standardized and pre-tested questionnaires were administered to the heads [...] anecdotal evidence point toward a relationship between an increased risk of suffering from NTDs and malaria and armed conflict. CONCLUSION: New research is needed to deepen our understanding of the often diffuse
Simplified models of vector control impact upon malaria transmission by zoophagic mosquitoes (Publications)
measures that kill mosquitoes dramatically reduce malaria transmission where vector populations depend upon human blood. However, most primary malaria vectors outside of sub-Saharan Africa can be classified
Modern geographical reconnaissance of target populations in malaria elimination zones (Publications)
approaches to GR to define the spatial distribution of target populations to support contemporary malaria elimination interventions. METHODS: Three GR surveys were carried out covering the outer islands [...] priority elimination interventions, including bed net distribution, indoor residual spraying (IRS) and malaria case surveillance. Data were uploaded and analysed in customized Geographic Information System (GIS) [...] operational tool for rapidly defining the spatial distribution of target...
Routine delivery of artemisinin-based combination treatment at fixed health facilities reduces malaria prevalence in Tanzania: an observational study (Publications)
combination therapy (ACT) has been promoted as a means to reduce malaria transmission due to their ability to kill both asexual blood stages of malaria parasites, which sustain infections over long periods and [...] between ACT introduction and reduced malaria transmission in a number of ecological settings. However, these reports have come from areas with low to moderate malaria transmission, been confounded by the [...] the presence of other interventions or environmental changes that may have...