Malaria infection prevalence and sensitivity of reactive case detection in Zanzibar (Publications)
BACKGROUND: Reactive case detection (RCD) is a commonly used strategy for malaria surveillance and response in elimination settings. Many approaches to RCD assume detectable infections are clustered within [...] household and up to 9 additional neighboring households. RESULTS: Of 12,487 participants tested by malaria rapid diagnostic test (RDT), 3.2% of those residing in index households and 0.4% of those residing [...] Sensitivity of RDT to detect qPCR-detectable infections was 34% (95%CI:...
The epidemiology of <em>Plasmodium falciparum </em>and <em>Plasmodium vivax</em> in East Sepik Province, Papua New Guinea, pre- and... (Publications)
of local heterogeneity in malaria transmission and the driving factors is critical to identify and implement targeted control strategies to ensure the ongoing success of malaria control in PNG and inform [...] BACKGROUND: In the past decade, national malaria control efforts in Papua New Guinea (PNG) have received renewed support, facilitating nationwide distribution of free long-lasting insecticidal nets (LLINs) [...] households (> 50% of household members with Plasmodium infection). CONCLUSION:...
Speech and language sequelae of severe malaria in Kenyan children (Publications)
impairments following severe malaria in Kenyan children. RESEARCH DESIGN: Cohort study comparing the prevalence of impairments in children exposed or unexposed to severe malaria. METHODS AND PROCEDURES: The [...] study recruited 25 children who had previously been admitted to hospital with severe falciparum malaria and 27 unexposed to the disease. Assessments of comprehension, syntax, lexical semantics, higher [...] at 8-9 years of age, at least 2 years after admission to hospital in children...
Methods and indicators for measuring patterns of human exposure to malaria vectors (Publications)
BACKGROUND: Effective targeting and evaluation of interventions that protect against adult malaria vectors requires an understanding of how gaps in personal protection arise. An improved understanding [...] collected and used consistently, this information can contribute to an improved understanding of how malaria transmission persists in the context of current intervention tools, how exposure patterns may change
Challenges in routine implementation and quality control of rapid diagnostic tests for malaria: Rufiji District, Tanzania (Publications)
Rapid diagnostic tests (RDTs) represent an alternative to microscopy for malaria diagnosis and have shown high sensitivity and specificity in a variety of study settings. Current World Health Organization [...] April 2007, we introduced a histidine-rich protein II (HRP2)-based RDT (Paracheck) for suspected malaria cases five years of age and older in nine health facilities in Rufiji District, Tanzania, to assess
Age as a risk factor for severe manifestations and fatal outcome of <em>falciparum</em> <em>malaria</em> in European patients: observations from... (Publications)
Previous studies have indicated that age is a risk factor for severe falciparum malaria in nonimmune patients. The objectives of this study were to reevaluate previous findings with a larger sample and [...] younger patients. Results of adjusted analyses indicated that the risks of death due to falciparum malaria, of experiencing cerebral or severe disease in general, and of hospitalization increased significantly [...] susceptible to cerebral complications than were men. Our study provides...