Passive immunoprotection of <em>Plasmodium falciparum</em>-infected mice designates the CyRPA as candidate malaria vaccine antigen (Publications)
An effective malaria vaccine could prove to be the most cost-effective and efficacious means of preventing severe disease and death from malaria. In an endeavor to identify novel vaccine targets, we tested [...] represents an unprecedented in vivo model for quantitative comparison of the functional potencies of malaria-specific Abs. Our data suggest a role for CyRPA in erythrocyte invasion by the merozoite. Inhibition [...] merozoite invasion by CyRPA-specific mAbs in vitro and in vivo renders...
Effect of the malaria vaccine combination B on merozoite surface antigen 2 diversity (Publications)
Plasmodium falciparum surface antigens. This poses a considerable obstacle to the development of a malaria vaccine. In order to assess possible effects of a polymorphic vaccine, we have analyzed the genetic
Pharmacotherapy, vaccines and malaria advice for HIV-infected travellers (Publications)
acquired during travel may be more frequent or severe. Challenges include the best options for malaria chemoprophylaxis, standby treatment and medical follow-up of the increasing number of HIV-infected
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria (Publications)
it was shown to be safe at doses up to 1,600 mg and is currently undergoing Phase IIa trials in malaria patients. Herein, we describe the discovery of OZ439 and the exceptional antimalarial and pharmacokinetic
Determining important parameters in the spread of malaria through the sensitivity analysis of a mathematical model (Publications)
We perform sensitivity analyses on a mathematical model of malaria transmission to determine the relative importance of model parameters to disease transmission and prevalence. We compile two sets of baseline [...] as the prompt diagnosis and treatment of infectious individuals) can be successful in controlling malaria
Intermittent preventive treatment for malaria in infants: a decision-support tool for sub-Saharan Africa (Publications)
clinical cases of Plasmodium falciparum malaria, hospital admissions for infection with malaria parasites and malaria-associated death for different levels of malaria transmission intensity and seasonality [...] with the severity of the malaria outcome and with transmission intensity. The decision-support tool, available on the Internet, provides estimates of the percentage of malaria-associated deaths, hospi [...] effectiveness of IPTi varies with malaria transmission intensity and seasonality....
