Potential for reduction of burden and local elimination of malaria by reducing <em>Plasmodium falciparum</em> malaria transmission: a mathematical... (Publications)
a mathematical model of the transmission of Plasmodium falciparum malaria to explore the potential effect on case incidence and malaria mortality rates from 2015 to 2030 of five different intervention [...] BACKGROUND: Rapid declines in malaria prevalence, cases, and deaths have been achieved globally during the past 15 years because of improved access to first-line treatment and vector control. We aimed [...] with a switch from quinine to injectable artesunate for management of severe disease...
Malaria molecular epidemiology: lessons from the International Centers of Excellence for Malaria Research Network (Publications)
and distribution of malaria cases. This article describes molecular epidemiologic investigations currently being carried out by the International Centers of Excellence for Malaria Research (ICEMR) network [...] network in a variety of malaria-endemic settings. First, we discuss various novel approaches to understand malaria incidence and gametocytemia, focusing on Plasmodium falciparum and Plasmodium vivax. Second [...] methods commonly used in malaria epidemiology and population genetics....
Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02D malaria vaccine in infants living in a... (Publications)
BACKGROUND: The RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization [...] compared to control. According to protocol population, vaccine efficacy against multiple episodes of malaria disease was 50.7% (95% CI: -6.5 to 77.1, p = 0.072) and 26.7% (95% CI: -33.1 to 59.6, p = 0.307) [...] to Treat population, over the 20-month follow up, vaccine efficacy against...
Comprehensive sterilization of malaria vectors using pyriproxyfen: a step closer to malaria elimination (Publications)
One of the main challenges to malaria elimination is the resilience of vectors, such as Anopheles arabiensis, that evade lethal exposure to insecticidal control measures or express resistance to their
Disparities of <em>Plasmodium falciparum</em> infection, malaria-related morbidity and access to malaria prevention and treatment among school-aged... (Publications)
There is limited knowledge on the malaria burden of school-aged children in Cote d'Ivoire. The aim of this study was to assess Plasmodium falciparum infection, malaria-related morbidity, use of preventive [...] preventive measures and treatment against malaria, and physical access to health structures among school-aged children across Cote d'Ivoire. METHODS: A national, cross-sectional study was designed, consisting [...] were interviewed to determine household socioeconomic status,...
Relationship between child survival and malaria transmission: an analysis of the malaria transmission intensity and mortality burden across Africa... (Publications)
relationship between malaria mortality and levels of transmission is unclear. Due to methodological limitations, earlier efforts to assess the linkage have lead to inconclusive results. The malaria transmission [...] assessing the malaria transmission-mortality relation involves more than the knowledge on the performance of interventions and control measures. This relation depends on the levels of malaria endemicity and [...] age and insecticide-treated nets (ITNs), were fitted to assess the...
Acridine Orange for malaria diagnosis: its diagnostic performance, its promotion and implementation in Tanzania, and the implications for malaria... (Publications)
for the organization of health services and the provision of effective treatment of malaria cases. The national malaria control programme of Tanzania, together with the Japan International Co-operation Agency [...] One hundred years ago, Giemsa's stain was employed for the first time for malaria diagnosis. Giemsa staining continues to be the method of choice in most malarious countries, although, in the recent past [...] Acridine Orange (AO). The literature on the discovery, development and...
