<em>Anopheles plumbeus</em> (Diptera: Culicidae) in Europe: a mere nuisance mosquito or potential malaria vector? (Publications)
of humans between Europe and malaria endemic countries and changes in environment and climate, these data strongly suggest that An. plumbeus could act as a vector for malaria and thus significantly contribute [...] to increasing the malaria transmission risk in Central-Western Europe. In locations showing high vulnerability to the presence of gametocyte carriers, the risk of transmission of malaria by An. plumbeus [...] ABSTRACT: BACKGROUND: Anopheles plumbeus has been recognized as a minor...
Simulation of the cost-effectiveness of malaria vaccines (Publications)
vaccination over 50% often exceed the benefits. CONCLUSION: The simulations indicate malaria vaccines might be efficient malaria control interventions, and that both transmission setting and vaccine delivery [...] BACKGROUND: A wide range of possible malaria vaccines is being considered and there is a need to identify which vaccines should be prioritized for clinical development. An important element of the information [...] individual-based stochastic model for the natural history and...
A review of malaria vaccine clinical projects based on the WHO rainbow table (Publications)
As the malaria community considers the potential role of a first-generation malaria vaccine in malaria control efforts, it is an apposite time to carefully document terminated and ongoing malaria vaccine [...] Phase 3 testing of the most advanced malaria vaccine, RTS,S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of several research malaria vaccines have also confirmed that [...] applied to increase the chances of success for second-generation malaria...
Cost-effectiveness of intermittent preventive treatment of malaria in infants (IPTi) for averting anaemia in Gabon: a comparison between intention to... (Publications)
BACKGROUND: In Gabon, the impact of intermittent preventive treatment of malaria in infants (IPTi) was not statistically significant on malaria reduction, but the impact on moderate anaemia was, with some differences
Immunogenicity of a virosomally-formulated <em>Plasmodium falciparum</em> GLURP-MSP3 chimeric protein-based malaria vaccine candidate in comparison to... (Publications)
immunogenicity of a virosomally-formulated recombinant fusion protein comprising domains of the two malaria vaccine candidate antigens MSP3 and GLURP. METHODS: The highly purified recombinant protein GMZ2 [...] GMZ2 thus represents a candidate component suitable for inclusion into a multi-valent virosomal malaria vaccine and influenza virosomes represent a versatile antigen delivery system suitable for adjuvant-free
Population hemoglobin mean and anemia prevalence in Papua New Guinea: new metrics for defining malaria endemicity? (Publications)
estimating malaria endemicity and for monitoring malaria control strategies. The aim of this study is to compare population hemoglobin mean and anemia prevalence to established indicators of malaria endemicity [...] of enlarged spleens in children, and records of (presumptive) malaria diagnosis among populations living with different levels of malaria transmission. METHODOLOGY/PRINCIPAL FINDINGS: Convenience sample
Bayesian geostatistical modelling of malaria and lymphatic filariasis infections in Uganda: predictors of risk and geographical patterns of... (Publications)
BACKGROUND: In Uganda, malaria and lymphatic filariasis (causative agent Wuchereria bancrofti) are transmitted by the same vector species of Anopheles mosquitoes, and thus are likely to share common e [...] children for circulating filarial antigens (CFA). Concurrently, blood smears were examined for malaria parasites. In this study, the resultant malariological data are analysed for the first time and the [...] different random effects to allow for spatial structuring and to capture potential...
Simulation of malaria epidemiology and control in the highlands of western Kenya (Publications)
METHODS: Individual-based stochastic simulation models of malaria in humans and a deterministic model of malaria in mosquitoes as part of the OpenMalaria platform were parameterized to create a scenario for [...] to assist in planning for the control and elimination of malaria. This work investigates the applicability of mathematical modelling of malaria transmission dynamics in Rachuonyo South, a district with [...] CONCLUSIONS: The OpenMalaria model of P. falciparum transmission can be used to...
A research agenda for malaria eradication: diagnoses and diagnostics (Publications)
or absent malaria transmission, sustaining interest in elimination and maintaining resources will become increasingly important. Thus, research is required into the context in which malaria diagnostic [...] Many of malaria's signs and symptoms are indistinguishable from those of other febrile diseases. Detection of the presence of Plasmodium parasites is essential, therefore, to guide case management. Improved
Design and pre-clinical profiling of a <em>Plasmodium falciparum</em> MSP-3 derived component for a multi-valent virosomal malaria vaccine (Publications)
BACKGROUND: Clinical profiling of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in [...] is suitable for use in humans and represents a candidate component for a virosomal multi-valent malaria subunit vaccine