Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite <em>Plasmodium falciparum</em> (Publications)
bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes [...] activation of sexual-stage-specific transcription and gametocyte formation. Our results reveal that malaria parasites can sense and process host-derived physiological signals to regulate differentiation. These [...] of the sexual differentiation pathway in Plasmodium that may provide...
Estimation of malaria parasite reservoir coverage using reactive case detection and active community fever screening from census data with rapid... (Publications)
areas where malaria transmission has been suppressed by vector control interventions many malaria control and elimination programmes are actively seeking new interventions to further reduce malaria prevalence [...] prevalence, incidence and transmission. Malaria infection prevalence and incidence has been shown to cluster geographically, especially at lower transmission levels, and as such a reactive strategy is frequently [...] infections than random searches, but this effect appears to be...
Clinical and laboratory predictors of death in African children with features of severe malaria: a systematic review and meta-analysis (Publications)
criteria for defining severe malaria have evolved over the last 20 years. We aimed to assess the strength of association of death with features currently characterizing severe malaria through a systematic review [...] Web of Knowledge) were searched to identify publications including African children with severe malaria. PRISMA guidelines were followed. Selection was based on design (epidemiological, clinical and treatment [...] treatment studies), setting (Africa), participants (children < 15...
The contribution of malaria control interventions on spatio-temporal changes of parasitaemia risk in Uganda during 2009-2014 (Publications)
BACKGROUND: In Uganda, malaria vector control interventions and case management with Artemisinin Combination Therapies (ACTs) have been scaled up over the last few years as a result of increased funding [...] children less than 5 years old and coverage of interventions was collected during the first two Malaria Indicator Surveys (MIS) conducted in 2009 and 2014, respectively. In this study, we quantify the [...] the North-East region to 100% in Kampala region. The estimated number of children...
Malaria case management by community health workers in the Central African Republic from 2009-2014: overcoming challenges of access and instability... (Publications)
infectious diseases, including malaria. As a response, in 2008 an international non-governmental organization started a network of community health workers (CHWs) in the highly malaria-endemic region of northwest [...] hence different stages of conflict and unrest. Several indicators were measured over time, including malaria rapid diagnostic test (RDT) positivity rates, CHW reporting rates, and malnutrition indicators. RESULTS: [...] nearly 200,000 people who consulted a CHW during this period,...
Fine-scale spatial and temporal heterogeneities in insecticide resistance profiles of the malaria vector,<em> Anopheles arabiensis</em> in rural... (Publications)
differences between districts, regions or countries. However, local heterogeneities in residual malaria transmission imply the need for finer-scale data. This study reports small-scale variations of i [...] villages across two seasons in Tanzania, where insecticidal bed nets are extensively used, but malaria transmission persists. Methods: WHO insecticide susceptibility assays were conducted on female and
Informing new or improved vector control tools for reducing the malaria burden in Tanzania: a qualitative exploration of perceptions of mosquitoes and... (Publications)
CONCLUSIONS: Outdoor transmission is widely accepted as an obstacle to malaria elimination. Larval source management, targeting both malaria vectors and nuisance-biting mosquitoes, is the preferred method for [...] BACKGROUND: The effectiveness of malaria prevention with long-lasting insecticidal nets and indoor residual spraying is limited by emerging insecticide resistance, evasive mosquito behaviours that include [...] to widespread environmental deterioration and lack of effective mosquito...
Fine-scale distribution of malaria mosquitoes biting or resting outside human dwellings in three low-altitude Tanzanian villages (Publications)
investigated the distribution of malaria mosquitoes biting or resting outside dwellings in three low-altitude villages in south-eastern Tanzania. The likelihood of malaria infections outdoors was also assessed [...] proportion of non-human blood-meals and absence of malaria-infected mosquitoes after 12 months of nightly trapping suggests very low-levels of outdoor malaria transmission in these villages. [...] BACKGROUND: While malaria transmission in Africa still happens primarily inside houses,...
