Reagent-free detection of <em>Plasmodium falciparum</em> malaria infections in field-collected mosquitoes using mid-infrared spectroscopy and machine... (Publications)
Field-derived metrics are critical for effective control of malaria, particularly in sub-Saharan Africa where the disease kills over half a million people yearly. One key metric is entomological inoculation [...] detect Plasmodium falciparum sporozoites in wild-caught Anopheles funestus, a major Afro-tropical malaria vector, without requiring any laboratory reagents. We collected 7178 female An. funestus from rural [...] detect P. falciparum in field-collected mosquitoes, with potential for...
Climate change, malaria and neglected tropical diseases: a scoping review (Publications)
To explore the effects of climate change on malaria and 20 neglected tropical diseases (NTDs), and potential effect amelioration through mitigation and adaptation, we searched for papers published from [...] 1543 full-text papers were assessed. Of 511 papers meeting the inclusion criteria, 185 studied malaria, 181 dengue and chikungunya and 53 leishmaniasis; other NTDs were relatively understudied. Mitigation [...] (34%) and adaption strategies in 24 (5%). Amplitude and direction of effects of...
Severe outcomes of malaria in children under time-varying exposure (Publications)
Plasmodium falciparum severe malaria dataset to better understand the relationship between prevalence and incidence of malaria pediatric hospitalizations - a proxy of malaria severe outcomes- in East-Africa [...] In malaria epidemiology, interpolation frameworks based on available observations are critical for policy decisions and interpreting disease burden. Updating our understanding of the empirical evidence [...] dynamics, and subsequent protection patterns in children, substantially...
The essential malaria protein <em>Pf</em>CyRPA targets glycans to invade erythrocytes (Publications)
Plasmodium falciparum is a human-adapted apicomplexan parasite that causes the most dangerous form of malaria. P. falciparum cysteine-rich protective antigen (PfCyRPA) is an invasion complex protein essential [...] immunotherapy, or a vaccine-primed immune response is a promising strategy to prevent and treat malaria.
Optimizing malaria vector control in the Greater Mekong Subregion: a systematic review and mathematical modelling study to identify desirable... (Publications)
the daytime and night-time to advance malaria elimination. METHODS: We conducted systematic literature searches to generate a bionomic dataset of the main malaria vectors in the GMS, including human blood
Evaluation of malaria rapid diagnostic test performance and <em>pfhrp2</em> deletion in Tanzania school surveys, 2017 (Publications)
As part of malaria nationwide monitoring and evaluation initiatives, there is an increasing trend of incorporating malaria rapid diagnostic tests (mRDTs) in surveys conducted within primary schools to [...] to detect malaria parasites. However, mRDTs based on the detection of histidine-rich protein 2 (HRP2) are known to yield false-positive results due to persistent antigenemia, and false-negative results may
Entomological survey of sibling species in the <em>Anopheles funestus</em> group in Tanzania confirms the role of <em>Anopheles parensis</em> as a... (Publications)
better understand the ecology and vectorial capacity of this and other secondary malaria vectors in the region to improve malaria control. [...] BACKGROUND: Malaria transmission in Tanzania is driven by mosquitoes of the Anopheles gambiae complex and Anopheles funestus group. The latter includes An. funestus s.s., an anthropophilic vector, which [...] provides the initial results of a cross-country study of the species composition, distribution and malaria transmission potential of members of...
Screening of malaria infections in human blood samples with varying parasite densities and anaemic conditions using AI-powered mid-infrared... (Publications)
accurately detect malaria infections across varying parasite densities and anaemic conditions. METHODS: Plasmodium falciparum strains NF54 and FCR3 were cultured and mixed with blood from 70 malaria-free individuals [...] unseen datasets to detect malaria at various parasitaemia levels and anaemic conditions. Additionally, these classifiers were tested on samples from a population survey in malaria-endemic villages of southeastern [...] complication in malaria patients. CONCLUSION: These...
A review of applications and limitations of using aquatic macroinvertebrate predators for biocontrol of the African malaria mosquito, <em>Anopheles... (Publications)
form malaria vector larval habitats. The presence of these predators in malaria vector larval habitats can negatively impact on development, adult body size, fecundity, and longevity of the malaria vectors [...] predators on malaria vectors warrant their consideration as biocontrol agents in an integrated program to combat malaria. However, the use of these macroinvertebrate predators in malaria biocontrol is [...] We reviewed the literature on the use of aquatic macroinvertebrate predators for...