Sustained malaria control over an 8-year period in Papua New Guinea: the challenge of low-density asymptomatic <em>Plasmodium</em> infections (Publications)
Background: The scale-up of effective malaria control in the last decade has resulted in a substantial decline in the incidence of clinical malaria in many countries. The effects on the proportions of [...] has resulted in reduced malaria transmission potential, but an increasing proportion of gametocyte carriers are asymptomatic and submicroscopic and represent a challenge to malaria control.
malERA: an updated research agenda for combination interventions and modelling in malaria elimination and eradication (Publications)
number of countries embarking on malaria elimination programmes, national and local decisions to select combinations of tools and deployment strategies directed at malaria elimination must address rapidly [...] This paper summarises key advances and priorities since the 2011 presentation of the Malaria Eradication Research Agenda (malERA), with a focus on the combinations of intervention tools and strategies [...] deployment against a heterogeneous transmission background is a challenge. Further...
malERA: an updated research agenda for characterising the reservoir and measuring transmission in malaria elimination and eradication (Publications)
key advances in defining the infectious reservoir for malaria and the measurement of transmission for research and programmatic use since the Malaria Eradication Research Agenda (malERA) publication in 2011 [...] is variable. New and improved measures of transmission need to be operationally feasible for the malaria programmes. Outputs from these research priorities should allow the development of a set of approaches
malERA: an updated research agenda for health systems and policy research in malaria elimination and eradication (Publications)
effectiveness of interventions ('effectiveness decay'), and respond to dynamic and changing needs. The malaria eradication research agenda (malERA) Refresh consultative process for the Panel on Health Systems [...] Research identifies opportunities to build health systems evidence and the tools needed to eliminate malaria from different zones, countries, and regions and to eradicate it globally. The research questions [...] include delivery strategies to meet the changing dynamics of needs of...
Infant and child mortality in relation to malaria transmission in KEMRI/CDC HDSS, Western Kenya: validation of verbal autopsy (Publications)
(VA) is widely used for estimating malaria specific mortality rates, but does not reliably distinguish malaria from other febrile illnesses. Overall malaria attributable mortality includes both direct and [...] both all-cause and malaria-specific mortality. 48.2% of the deaths could be attributed to malaria by analysing the exposure-response relationship, though only 20.5% of VAs assigned malaria as the cause and [...] BACKGROUND: Malaria transmission reduction is a goal of many malaria control...
Mapping multiple components of malaria risk for improved targeting of elimination interventions (Publications)
component, related mappable malaria metrics are also described which may be measured and evaluated by malaria programmes seeking to better understand the determinants of malaria risk. Implementing tailored [...] There is a long history of considering the constituent components of malaria risk and the malaria transmission cycle via the use of mathematical models, yet strategic planning in endemic countries tends [...] tends not to take full advantage of available disease intelligence to tailor...
The ethics of health care delivery in a pediatric malaria vaccine trial: the perspectives of stakeholders from Ghana and Tanzania (Publications)
care to participants and communities of low-resource settings involved in a Phase II/III pediatric malaria vaccine trial (PMVT). We conducted 52 key informant interviews with major stakeholders of an int