Community knowledge, attitude, practices and beliefs associated with persistence of malaria transmission in north-western and southern regions of... (Publications)
cause of malaria, and thought that it is caused by bathing and drinking un-boiled water, or consuming contaminated food that has malaria parasites without warming it. Reported barriers to malaria prevention [...] Kigoma, Mtwara and Ruvuma) with persistently high malaria transmission for more than two decades. RESULTS: Most of the participants had good knowledge of malaria and how it is transmitted but some FGD participants [...] economic activities that potentially contributed to persistence of ...
Accessibility of malaria commodities in Geita District Council, Mainland Tanzania: the experiences from healthcare providers and clients (Publications)
BACKGROUND: Access to essential malaria commodities is a cornerstone in malaria control. However optimal availability and access to essential malaria commodities remain a challenge in Tanzania. Therefore [...] the accessibility, of malaria commodities in private and faith-based health facilities is still sub-optimal. Logistic management needs to be improved to eliminate stockouts and malaria commodities high costs [...] Therefore, this study aimed to explore the factors affecting the...
Design and selection of drug properties to increase the public health impact of next-generation seasonal malaria chemoprevention: a modelling study (Publications)
BACKGROUND: Seasonal malaria chemoprevention (SMC) is recommended for disease control in settings with moderate to high Plasmodium falciparum transmission and currently depends on the administration of [...] threaten the effectiveness of SMC. Guidance is needed to de-risk the development of drug compounds for malaria prevention. We aimed to provide guidance for the early prioritisation of new and alternative SMC [...] their target product profiles. METHODS: In this modelling study, we combined...
Correction: Testing and treatment for malaria elimination: a systematic review (Publications)
Correction: Malaria Journal (2023) 22:254 https://doi.org/10.1186/s12936-023-04670-8
Sporozoite immunization: innovative translational science to support the fight against malaria (Publications)
'sporozoites,' 'malaria,' and 'vaccines.' EXPERT OPINION: First generation (radiation-attenuated) PfSPZ vaccines are safe, well tolerated, 80-100% efficacious against homologous controlled human malaria infection [...] INTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly [...] effective vaccine is urgently needed, especially for Plasmodium...
Malaria in Angola: recent progress, challenges and future opportunities using parasite demography studies (Publications)
of malaria interventions has occurred at the national level in Angola, together with cross-border initiatives and regional efforts in southern Africa. Currently, Angola aims to consolidate malaria control [...] heterogeneity in malaria prevalence among Angolan provinces, as well as internal population movements and migration across borders, represent major challenges for the Angolan National Malaria Control Programme [...] Programme. This review aims to contribute to the understanding of factors...
Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and... (Publications)
BACKGROUND: Rectal artesunate, an efficacious pre-referral treatment for severe malaria in children, was deployed at scale in Uganda, Nigeria, and DR Congo. In addition to distributing rectal artesunate [...] tion required additional investments in crucial but neglected components in the care for severe malaria. We examined the real-world costs and constraints to rectal artesunate implementation. METHODS: We [...] annual cost of rectal artesunate implementation per child younger than 5 years at...
Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and <em>in vivo</em> efficacy in a... (Publications)
Iterative medicinal chemistry optimization of an ester-containing astemizole (AST) analogue 1 with an associated metabolic instability liability led to the identification of a highly potent 3-trifluor