Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial... (Publications)
count during acute uncomplicated malaria, and estimate the impact of using an assumed value of WBC on estimates of parasite density and clearance. METHODS: Uncomplicated malaria drug efficacy studies that measured [...] and vivax (n = 2678) malaria, respectively. At presentation, higher WBC counts were seen among patients with higher parasitaemia, severe anaemia and, for individuals with vivax malaria, in regions with shorter [...] reference. RESULTS: Eighty-four studies enrolling 27,656...
Malaria, climate variability, and interventions: modelling transmission dynamics (Publications)
of the relative impact of climate change on malaria dynamics is a complex problem. Climate is a well-known factor that plays a crucial role in driving malaria outbreaks in epidemic transmission areas. However [...] influence in endemic environments with intensive malaria control interventions is not fully understood, mainly due to the scarcity of high-quality, long-term malaria data. The demographic surveillance systems [...] effects of weather variability on the burden of malaria. Here, using a...
Modelling the impact of interventions on imported, introduced and indigenous malaria infections in Zanzibar, Tanzania (Publications)
Malaria cases can be classified as imported, introduced or indigenous cases. The World Health Organization's definition of malaria elimination requires an area to demonstrate that no new indigenous cases [...] cases have occurred in the last three years. Here, we present a stochastic metapopulation model of malaria transmission that distinguishes between imported, introduced and indigenous cases, and can be used [...] interventions in a setting with low transmission and ongoing case...
Acceptability, feasibility, drug safety, and effectiveness of a pilot mass drug administration with a single round of sulfadoxine-pyrimethamine plus... (Publications)
For a malaria elimination strategy, Haiti's National Malaria Control Program piloted a mass drug administration (MDA) with indoor residual spraying (IRS) in 12 high-transmission areas across five communes [...] round of MDA/IRS on malaria transmission was not found using a standard pre- and post-intervention comparison, it is possible there was blunting of the peak transmission. Seasonal malaria transmission patterns
The relative effect of climate variability on malaria incidence after scale-up of interventions in western Kenya: a time-series analysis of monthly... (Publications)
effect of climate variability on malaria incidence after scale-up of interventions in western Kenya. Methods Bayesian negative binomial models were fitted to monthly malaria incidence data, extracted from [...] variable selection was used to determine the elapsing time between climate suitability and malaria incidence. Results Malaria incidence increased by 50% from 2008 to 2010, then declined by 73% until 2015. There [...] associated with a decline in malaria incidence in children aged 6–59...
Modelling to inform next-generation medical interventions for malaria prevention and treatment (Publications)
Global progress against malaria has stagnated and novel medical interventions to prevent malaria are needed to fill gaps in existing tools and improve protection against infection and disease. Candidate [...] opportunity to link product characteristics with expected public health outcomes. Population models of malaria transmission can provide a better understanding of which, and at what magnitude, key intervention [...] deployment strategies. We describe how modelling evidence can guide and...
