Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis (Publications)
Of 2887 travellers between the years 1984-1985, 451 on prophylactic antimalarials were studied retrospectively for adverse haematological or hepatic drug reactions and compared to 296 drug non-users.
Die Falciparum-Malaria in der Schweiz: ein Problem der Intensivmedizin? (Publications)
the period 1972-1976, 5 of 17 patients admitted to the Cantonal Hospital, Basel, for falciparum malaria had to be treated in the intensive care unit. Two patients died. None had performed regular chem [...] several days had elapsed between onset of symptoms and diagnosis. The importance of information on malaria to tourists and physicians is stressed.
Epidemiologie und Klinik der Malaria in der Schweiz (Publications)
thirds of all cases of malaria in Switzerland are imported from Africa. Accordingly, malignant malaria is more frequently diagnosed in Switzerland than tertian malaria. Malignant malaria usually presents atypically [...] shock. The lethality is high. The majority of Swiss travellers are not protected effectively against malaria. A group particularly at risk are tourists of 20--30 years of age. It is suggested that travel agencies [...] the medical profession should intensify public information...
Das Antiarrhythmikum Chinidin als Alternative in der Behandlung der schweren Falciparum-Malaria (Publications)
quinidine, usually stocked by hospitals, is an alternative drug for malaria treatment. We report the cases of two patients with severe malaria imported from Kenya. They were treated first with intravenous quinidine [...] Parenteral quinine is the most effective treatment for severe falciparum malaria. It is not easily available in Switzerland and so dangerous delays treating patients may occur. The antiarrhythmic drug [...] mg/kg b.w./die of quinidine given intravenously seems to be an adequate...
The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
Malaria parasites undergo a complex life cycle in the human host and the mosquito vector. The ApiAP2 family of DNA-binding proteins plays a dominant role in parasite development and life cycle progression [...] maintenance. In summary, our findings reveal PfAP2-HC as a core component of heterochromatin in malaria parasites and identify unexpected properties and substantial functional divergence among the members
Bayesian spatial models applied to malaria epidemiology (Publications)
scaling-up. Contemporary information on malaria prevalence for this work was provided mostly by Malaria Indicator Surveys (MIS) and Demographic Health Surveys (DHS) with malaria modules. MIS are nationally rep [...] impressive increases in international funding for malaria prevention, control, and elimination, which have led to tremendous expansion in implementing national malaria control programs (NMCPs). Common interventions [...] (MDG) 6 aims to halve malaria incidence by 2015 as compared to...
Effect of interventions to reduce malaria incidence among military personnel on active duty: study protocol for a cluster randomised controlled trial... (Publications)
studies assessing the impact on malaria infection. This study will estimate the protective efficacy of treated uniforms and DEET insect repellent on the incidence of malaria infection among military personnel [...] placebo-controlled trial is planned to evaluate the effectiveness of the interventions on preventing malaria infections in soldiers on active duty at Mgambo National Service Camp in Tanga, Tanzania. The arms [...] untreated uniforms with placebo lotion. The primary outcome is the...