Revisiting the effect of pharmaceuticals on transmission stage formation in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
Malaria parasites rely on specialized stages, called gametocytes, to ensure human-to-human transmission. The formation of these sexual precursor cells is initiated by commitment of blood stage parasites [...] vivo. These observations suggest that therapeutic interventions may promote gametocytogenesis and malaria transmission. Here, we engineered a P. falciparum reporter line to quantify sexual commitment rates [...] rates after exposure to antimalarials and other pharmaceuticals commonly...
Leveraging mathematical models of disease dynamics and machine learning to improve development of novel malaria interventions (Publications)
targeted reductions in malaria prevalence. METHODS: A mathematical model of malaria transmission dynamics is used to simulate deployment and predict potential impact of new malaria interventions by considering [...] mathematical models of malaria dynamics coupled with machine learning. Our analysis identifies requirements of efficacy, coverage, and duration of effect for five novel malaria interventions to achieve [...] achieve specified health goals. RESULTS: We apply our approach to five malar...
The beauty of disease modelling (Page)
https://www.swisstph.ch/fr/impact-stories/the-beauty-of-disease-modelling
modelling for malaria vaccines? Similar to vaccines, we often ask questions about how we can can reduce the burden of disease. Many of the malaria models that were created to look at malaria vaccines have [...] modelling here is not just estimating the impact of the malaria vaccine or a single intervention but we can ask a whole range of questions about malaria disease dynamics, intervention packages and drug resistance [...] n packages for different national malaria control programmes....
“It is a privilege to be able to bring science to the bedside” (Page)
https://www.swisstph.ch/fr/impact-stories/it-is-a-privilege-to-be-able-to-bring-science-to-the-bedside
test a drug for a neglected disease such as malaria, the trial can become more complex, because we have to go where the malaria patients are, i.e., to a malaria-endemic country such as the DRC. Such sites [...] very effective and affordable medicines for malaria? Yes, artemisinin-based combination therapies (ACTs) are still the standard of care for treating malaria and remain very effective. However, we are seeing [...] in the fight against malaria? What is unique about Swiss TPH is that we work...
New approaches to transform global health: meeting with Bill Gates (Page)
https://www.swisstph.ch/fr/impact-stories/new-approaches-to-transform-health-in-low-and-middle-income-countries-a-swiss-tph-researcher-discussed-with-bill-gates
technical support to the National Malaria Control Programme (NMCP) in various malaria surveillance activities as part of the Swiss TPH Towards Elimination of Malaria in Tanzania (TEMT) project . You recently [...] facility data be used to improve malaria interventions? Since 2000, there has been a renewed commitment to malaria control, resulting in increased funding to support various malaria control interventions across [...] routine data from local health facilities in the fight against malari...
Diagnostikkurse in medizinischer Parasitologie | Swiss TPH Short Courses (Page)
https://www.swisstph.ch/fr/study-with-us/postgraduate/diagnostikkurse-in-medizinischer-parasitologie
steht die Differentialdiagnostik der jeweiligen Krankheitserregern. Kursbeschreibung Malaria Der direkte Nachweis von Malaria-Erregern im Blut ist trotz moderner molekularer Diagnostikverfahren immer noch die [...] gewidmet. Eine Blinddiagnose am Ende des Kurses ermöglicht die Selbstüberprüfung. Malaria + Bei Blutuntersuchungen auf Malaria werden häufig nicht die klassischen Formen gefunden, sondern Parasiten, deren [...] 2024: Blutparasiten für Fortgeschrittene: 21. November 2024, ABGESAGT...
Swiss TPH at Global Level (Page)
https://www.swisstph.ch/fr/topics/malaria/swiss-tph-at-global-level
the Second Global Malaria Action Plan “Action and Investment to defeat Malaria 2016-2030 (AIM) for a malaria-free world.” Malaria Antimalarial Drug Development Malaria Vaccines Malaria Elimination Surveillance [...] Influencing Global Malaria Policies The Global Malaria Technical and Training Support Package (GlobMal) aims at influencing global malaria policies and implementing WHO and Roll Back Malaria Partnership strategies [...] reduce the malaria burden and to expand malaria-free zones...
Kelly Chibale: Learning to Fail Your Way to Success (Page)
https://www.swisstph.ch/fr/impact-stories/kelly-chibale-learning-to-fail-your-way-to-success
with Kelly and his team and his contributions for malaria and schistosomiasis drug discovery and development have been seminal.” New Drugs against Malaria The success of the H3D was not long in coming. In [...] University of Cape Town. He dedicated himself to the discovery and development of new drugs against malaria and other infectious diseases of poverty. This career move was not based on an idealistic sentiment [...] international partnerships. Key partners include the Bill & Melinda Gates...
Vaccination: A Cornerstone of Global Health (Page)
https://www.swisstph.ch/fr/impact-stories/vaccination-a-cornerstone-of-global-health
Hotez Selected contributions of Swiss TPH’s research on malaria vaccine development Abdulla et al. Safety and immunogenicity of RTS,S/AS02D malaria vaccine in infants. N Engl J Med. 2008;359(24):2533-44 [...] against Plasmodium falciparum malaria in children in southern Tanzania. Lancet. 1994;344(8931):1175-81. doi: 10.1016/s0140-6736(94)90505-3. Day et al. The essential malaria protein PfCyRPA targets glycans [...] interventions for malaria prevention and treatment. Commun Med (Lond)....
PNG Programme (Page)
https://www.swisstph.ch/fr/about/eph/health-interventions/intervention-effectiveness-and-impact/png-programme
Papua New Guinea Malaria Indicator Survey 2019-2020: Final Report on Malaria Prevention, Infection Prevalence, and Treatment-Seeking Papua New Guinea Malaria Indicator Survey 2016-2017: Malaria Prevention, [...] Document Changes in Malaria Prevalence Five national Malaria Indicator Surveys (MIS) conducted since 2008 have documented a substantial decrease in the country-wide prevalence of malaria infections in the [...] clinical malaria cases over time complementing national routine statistics....