Feasibility and acceptability of insecticide-treated plastic sheeting (ITPS) for vector control in Papua New Guinea (Publications)
sheeting (ITPS) as a malaria control intervention in Papua New Guinea (PNG). METHODS: ZeroVector(R) ITPS was installed in 40 homes across four study sites representing a cross section of malaria transmission risk [...] potential application of ITPS in the national malaria control programme. The positive study findings suggest a longer-term evaluation of this promising malaria control intervention warrants consideration
Safety and differential antibody and T-cell responses to <em>Plasmodium falciparum</em> sporozoite vaccine by age in Tanzanian adults, adolescents,... (Publications)
2016, there were more cases and deaths caused by malaria globally than in 2015. An effective vaccine would be an ideal additional tool for reducing malaria's impact. Sanaria((R)) PfSPZ Vaccine, composed [...] (SPZ) has been well tolerated and safe in malaria-naive and experienced adults in the United States and Mali and protective against controlled human malaria infection with Pf in the United States and
The effects and contribution of childhood diseases on the geographical distribution of all-cause under-five mortality in Uganda (Publications)
were obtained from the 2011 Demographic and Health Survey, while data on malaria prevalence were extracted from the 2009 Malaria Indicator Survey. Bayesian geostatistical Weibull proportional hazards models [...] five years in Uganda were attributable to malaria, severe/moderate anaemia, severe/moderate malnutrition and diarrhoea respectively. The attribution of malaria was comparable in Central 2, East-Central [...] used household surveys to quantify the effects and contribution of main...
The effects and contribution of childhood diseases on the geographical distribution of all-cause under-five mortality in Uganda (Publications)
were obtained from the 2011 Demographic and Health Survey, while data on malaria prevalence were extracted from the 2009 Malaria Indicator Survey. Bayesian geostatistical Weibull proportional hazards models [...] five years in Uganda were attributable to malaria, severe/moderate anaemia, severe/moderate malnutrition and diarrhoea respectively. The attribution of malaria was comparable in Central 2, East-Central [...] used household surveys to quantify the effects and contribution of main...
Our exciting journey to ACT-451840 (Publications)
broadly characterized in vitro as well as in vivo in rat PK experiments as well as two different mouse malaria models. In the P. berghei infected mouse model cure could be achieved at oral doses of 300 mg/kg [...] mg/kg over 3 consecutive days. ACT-451840 was clinically investigated up to an experimental human malaria infection model, where therapeutic effects could be shown.
Our exciting journey to ACT-451840 (Publications)
broadly characterized in vitro as well as in vivo in rat PK experiments as well as two different mouse malaria models. In the P. berghei infected mouse model cure could be achieved at oral doses of 300 mg/kg [...] mg/kg over 3 consecutive days. ACT-451840 was clinically investigated up to an experimental human malaria infection model, where therapeutic effects could be shown.
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across... (Publications)
blood life-cycle stage of the human malaria parasite Plasmodium falciparum. Several compounds displayed high in vivo efficacy in two different mouse models for malaria, P. berghei-infected mice and P. f
Cryptic population structure and insecticide resistance in <em>Anopheles gambiae</em> from the southern Democratic Republic of Congo (Publications)
Congo (DRC) suffers from one of the highest malaria burdens worldwide, but information on its Anopheles vector populations is relatively limited. Preventative malaria control in DRC is reliant on pyrethroid-treated
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across... (Publications)
blood life-cycle stage of the human malaria parasite Plasmodium falciparum. Several compounds displayed high in vivo efficacy in two different mouse models for malaria, P. berghei-infected mice and P. f
Detection of antibodies to <em>Plasmodium falciparum</em> sporozoites by employing synthetic peptides (Publications)
A new achievement in the immunodiagnosis of malaria has been reached after the knowledge of the molecular structure of some plasmodial antigens has become available. One example is given by the repetitive [...] immunosorbent assay (ELISA) for the detection of antisporozoite antibodies in individuals from malaria-endemic countries. This (NANP)40 ELISA has been employed in a longitudinal study in a rural community [...] and can be useful for monitoring the immune status of populations...